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Comparison of risk factors of macrovascular complications. Peripheral vascular disease, cerebral vascular disease, and coronary heart disease in Japanese type 2 diabetes mellitus patients.
J Diabetes Complications 2000 Nov-Dec; 14(6):307-13JD

Abstract

Although macroangiopathies such as peripheral vascular disease (PVD), cerebral vascular disease (CVD), and coronary heart disease (CHD) can often be observed in patients with diabetes mellitus, they are not specific for diabetes mellitus. Moreover, it is unclear whether their progressive mechanism is different. In the present study, we compared the risk factors among the diabetic macrovascular complications. Univariate analyses showed that in all patients, age at examination, duration of diabetes, thrombin-antithrombin III complex (TAT) level, fibrinogen level, lipoprotein (a) (Lp(a)) level, total cholesterol (T-Chol) level, and existence of microagiopathy were risk factors for PVD. Age, duration of diabetes, insulin level, TAT level, fibrinogen level, HDL cholesterol (HDL-Chol) level, hypertension, and nephropathy were risk factors for CVD. Only fibrinogen level was a risk factor for CHD. Moreover, Lp(a) level was a risk factor for PVD and CVD in male patients, but not in females. On the other hand, insulin level was a risk factor for CVD in female patients, but not in males. Multivariate analyses showed that TAT level, T-Chol level, and neuropathy were independent variables for PVD and that age, TAT level, and HDL-Chol level were independent variables for CVD. On the other hand, only fibrinogen level was the independent variable for CHD in males. Our results suggest that the progressive mechanism of PVD and CVD might be different from that of CHD and might differ according to gender in Japanese diabetic patients.

Authors+Show Affiliations

Department of Endocrinology and Metabolism, Itami City Hospital, 1-100, Koyaike, Hyogo, 664-8540, Itami, Japan. hasakawa@osk.3web.ne.jpNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

11120454

Citation

Asakawa, H, et al. "Comparison of Risk Factors of Macrovascular Complications. Peripheral Vascular Disease, Cerebral Vascular Disease, and Coronary Heart Disease in Japanese Type 2 Diabetes Mellitus Patients." Journal of Diabetes and Its Complications, vol. 14, no. 6, 2000, pp. 307-13.
Asakawa H, Tokunaga K, Kawakami F. Comparison of risk factors of macrovascular complications. Peripheral vascular disease, cerebral vascular disease, and coronary heart disease in Japanese type 2 diabetes mellitus patients. J Diabetes Complicat. 2000;14(6):307-13.
Asakawa, H., Tokunaga, K., & Kawakami, F. (2000). Comparison of risk factors of macrovascular complications. Peripheral vascular disease, cerebral vascular disease, and coronary heart disease in Japanese type 2 diabetes mellitus patients. Journal of Diabetes and Its Complications, 14(6), pp. 307-13.
Asakawa H, Tokunaga K, Kawakami F. Comparison of Risk Factors of Macrovascular Complications. Peripheral Vascular Disease, Cerebral Vascular Disease, and Coronary Heart Disease in Japanese Type 2 Diabetes Mellitus Patients. J Diabetes Complicat. 2000;14(6):307-13. PubMed PMID: 11120454.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of risk factors of macrovascular complications. Peripheral vascular disease, cerebral vascular disease, and coronary heart disease in Japanese type 2 diabetes mellitus patients. AU - Asakawa,H, AU - Tokunaga,K, AU - Kawakami,F, PY - 2000/12/20/pubmed PY - 2001/3/3/medline PY - 2000/12/20/entrez SP - 307 EP - 13 JF - Journal of diabetes and its complications JO - J. Diabetes Complicat. VL - 14 IS - 6 N2 - Although macroangiopathies such as peripheral vascular disease (PVD), cerebral vascular disease (CVD), and coronary heart disease (CHD) can often be observed in patients with diabetes mellitus, they are not specific for diabetes mellitus. Moreover, it is unclear whether their progressive mechanism is different. In the present study, we compared the risk factors among the diabetic macrovascular complications. Univariate analyses showed that in all patients, age at examination, duration of diabetes, thrombin-antithrombin III complex (TAT) level, fibrinogen level, lipoprotein (a) (Lp(a)) level, total cholesterol (T-Chol) level, and existence of microagiopathy were risk factors for PVD. Age, duration of diabetes, insulin level, TAT level, fibrinogen level, HDL cholesterol (HDL-Chol) level, hypertension, and nephropathy were risk factors for CVD. Only fibrinogen level was a risk factor for CHD. Moreover, Lp(a) level was a risk factor for PVD and CVD in male patients, but not in females. On the other hand, insulin level was a risk factor for CVD in female patients, but not in males. Multivariate analyses showed that TAT level, T-Chol level, and neuropathy were independent variables for PVD and that age, TAT level, and HDL-Chol level were independent variables for CVD. On the other hand, only fibrinogen level was the independent variable for CHD in males. Our results suggest that the progressive mechanism of PVD and CVD might be different from that of CHD and might differ according to gender in Japanese diabetic patients. SN - 1056-8727 UR - https://www.unboundmedicine.com/medline/citation/11120454/Comparison_of_risk_factors_of_macrovascular_complications__Peripheral_vascular_disease_cerebral_vascular_disease_and_coronary_heart_disease_in_Japanese_type_2_diabetes_mellitus_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1056-8727(00)00092-1 DB - PRIME DP - Unbound Medicine ER -