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Assessment of various topical oral formulations by bone marrow transplant recipients.
Oral Oncol 2001; 37(1):42-9OO

Abstract

Topical approaches to management of oral mucositis have the advantages of high local concentration and limited or no systemic absorption, reducing the risk of systemic complications. The acceptability of topical therapies in cancer patients has not been evaluated. Thirty-eight transplant patients assessed the acceptability of three formulations (rinse, thin gel, thick gel) of a new compound developed to prevent oral mucositis. The rinse was selected as the most acceptable formulation. The thick gel received the lowest rating. Consistency was a major determinant of overall acceptability. A neutral taste was desirable for most participants. Room temperature of the formulation was rated as completely acceptable. Most participants would be willing to use the rinse or thin gel several times per day, to retain each dose in the oral cavity for up to 5 min, and to swallow it. The support of caregivers may be needed to achieve compliance with such regimens.

Authors+Show Affiliations

IntraBiotics Pharmaceuticals Inc., Mountain View, CA 94043, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11120482

Citation

Bellm, L A., et al. "Assessment of Various Topical Oral Formulations By Bone Marrow Transplant Recipients." Oral Oncology, vol. 37, no. 1, 2001, pp. 42-9.
Bellm LA, Epstein JB, Rose-Ped AM, et al. Assessment of various topical oral formulations by bone marrow transplant recipients. Oral Oncol. 2001;37(1):42-9.
Bellm, L. A., Epstein, J. B., Rose-Ped, A. M., Fu, R., Martin, P. J., & Fuchs, H. J. (2001). Assessment of various topical oral formulations by bone marrow transplant recipients. Oral Oncology, 37(1), pp. 42-9.
Bellm LA, et al. Assessment of Various Topical Oral Formulations By Bone Marrow Transplant Recipients. Oral Oncol. 2001;37(1):42-9. PubMed PMID: 11120482.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment of various topical oral formulations by bone marrow transplant recipients. AU - Bellm,L A, AU - Epstein,J B, AU - Rose-Ped,A M, AU - Fu,R, AU - Martin,P J, AU - Fuchs,H J, PY - 2000/12/20/pubmed PY - 2002/1/5/medline PY - 2000/12/20/entrez SP - 42 EP - 9 JF - Oral oncology JO - Oral Oncol. VL - 37 IS - 1 N2 - Topical approaches to management of oral mucositis have the advantages of high local concentration and limited or no systemic absorption, reducing the risk of systemic complications. The acceptability of topical therapies in cancer patients has not been evaluated. Thirty-eight transplant patients assessed the acceptability of three formulations (rinse, thin gel, thick gel) of a new compound developed to prevent oral mucositis. The rinse was selected as the most acceptable formulation. The thick gel received the lowest rating. Consistency was a major determinant of overall acceptability. A neutral taste was desirable for most participants. Room temperature of the formulation was rated as completely acceptable. Most participants would be willing to use the rinse or thin gel several times per day, to retain each dose in the oral cavity for up to 5 min, and to swallow it. The support of caregivers may be needed to achieve compliance with such regimens. SN - 1368-8375 UR - https://www.unboundmedicine.com/medline/citation/11120482/Assessment_of_various_topical_oral_formulations_by_bone_marrow_transplant_recipients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1368-8375(00)00054-3 DB - PRIME DP - Unbound Medicine ER -