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Association between alpha-tocopherol, gamma-tocopherol, selenium, and subsequent prostate cancer.
J Natl Cancer Inst 2000; 92(24):2018-23JNCI

Abstract

BACKGROUND

Selenium and alpha-tocopherol, the major form of vitamin E in supplements, appear to have a protective effect against prostate cancer. However, little attention has been paid to the possible role of gamma-tocopherol, a major component of vitamin E in the U.S. diet and the second most common tocopherol in human serum. A nested case-control study was conducted to examine the associations of alpha-tocopherol, gamma-tocopherol, and selenium with incident prostate cancer.

METHODS

In 1989, a total of 10,456 male residents of Washington County, MD, donated blood for a specimen bank. A total of 117 of 145 men who developed prostate cancer and 233 matched control subjects had toenail and plasma samples available for assays of selenium, alpha-tocopherol, and gamma-tocopherol. The association between the micronutrient concentrations and the development of prostate cancer was assessed by conditional logistic regression analysis. All statistical tests were two-sided.

RESULTS

The risk of prostate cancer declined, but not linearly, with increasing concentrations of alpha-tocopherol (odds ratio (highest versus lowest fifth) = 0.65; 95% confidence interval = 0.32--1.32; P(trend) =.28). For gamma-tocopherol, men in the highest fifth of the distribution had a fivefold reduction in the risk of developing prostate cancer than men in the lowest fifth (P:(trend) =.002). The association between selenium and prostate cancer risk was in the protective direction with individuals in the top four fifths of the distribution having a reduced risk of prostate cancer compared with individuals in the bottom fifth (P(trend) =.27). Statistically significant protective associations for high levels of selenium and alpha-tocopherol were observed only when gamma-tocopherol concentrations were high.

CONCLUSIONS

The use of combined alpha- and gamma- tocopherol supplements should be considered in upcoming prostate cancer prevention trials, given the observed interaction between alpha-tocopherol, gamma-tocopherol, and selenium.

Authors+Show Affiliations

Department of Epidemiology, The Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205, USA. Khelzlso@jhsph.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11121464

Citation

Helzlsouer, K J., et al. "Association Between Alpha-tocopherol, Gamma-tocopherol, Selenium, and Subsequent Prostate Cancer." Journal of the National Cancer Institute, vol. 92, no. 24, 2000, pp. 2018-23.
Helzlsouer KJ, Huang HY, Alberg AJ, et al. Association between alpha-tocopherol, gamma-tocopherol, selenium, and subsequent prostate cancer. J Natl Cancer Inst. 2000;92(24):2018-23.
Helzlsouer, K. J., Huang, H. Y., Alberg, A. J., Hoffman, S., Burke, A., Norkus, E. P., ... Comstock, G. W. (2000). Association between alpha-tocopherol, gamma-tocopherol, selenium, and subsequent prostate cancer. Journal of the National Cancer Institute, 92(24), pp. 2018-23.
Helzlsouer KJ, et al. Association Between Alpha-tocopherol, Gamma-tocopherol, Selenium, and Subsequent Prostate Cancer. J Natl Cancer Inst. 2000 Dec 20;92(24):2018-23. PubMed PMID: 11121464.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between alpha-tocopherol, gamma-tocopherol, selenium, and subsequent prostate cancer. AU - Helzlsouer,K J, AU - Huang,H Y, AU - Alberg,A J, AU - Hoffman,S, AU - Burke,A, AU - Norkus,E P, AU - Morris,J S, AU - Comstock,G W, PY - 2000/12/21/pubmed PY - 2001/5/18/medline PY - 2000/12/21/entrez SP - 2018 EP - 23 JF - Journal of the National Cancer Institute JO - J. Natl. Cancer Inst. VL - 92 IS - 24 N2 - BACKGROUND: Selenium and alpha-tocopherol, the major form of vitamin E in supplements, appear to have a protective effect against prostate cancer. However, little attention has been paid to the possible role of gamma-tocopherol, a major component of vitamin E in the U.S. diet and the second most common tocopherol in human serum. A nested case-control study was conducted to examine the associations of alpha-tocopherol, gamma-tocopherol, and selenium with incident prostate cancer. METHODS: In 1989, a total of 10,456 male residents of Washington County, MD, donated blood for a specimen bank. A total of 117 of 145 men who developed prostate cancer and 233 matched control subjects had toenail and plasma samples available for assays of selenium, alpha-tocopherol, and gamma-tocopherol. The association between the micronutrient concentrations and the development of prostate cancer was assessed by conditional logistic regression analysis. All statistical tests were two-sided. RESULTS: The risk of prostate cancer declined, but not linearly, with increasing concentrations of alpha-tocopherol (odds ratio (highest versus lowest fifth) = 0.65; 95% confidence interval = 0.32--1.32; P(trend) =.28). For gamma-tocopherol, men in the highest fifth of the distribution had a fivefold reduction in the risk of developing prostate cancer than men in the lowest fifth (P:(trend) =.002). The association between selenium and prostate cancer risk was in the protective direction with individuals in the top four fifths of the distribution having a reduced risk of prostate cancer compared with individuals in the bottom fifth (P(trend) =.27). Statistically significant protective associations for high levels of selenium and alpha-tocopherol were observed only when gamma-tocopherol concentrations were high. CONCLUSIONS: The use of combined alpha- and gamma- tocopherol supplements should be considered in upcoming prostate cancer prevention trials, given the observed interaction between alpha-tocopherol, gamma-tocopherol, and selenium. SN - 0027-8874 UR - https://www.unboundmedicine.com/medline/citation/11121464/Association_between_alpha_tocopherol_gamma_tocopherol_selenium_and_subsequent_prostate_cancer_ L2 - https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/92.24.2018 DB - PRIME DP - Unbound Medicine ER -