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Unilateral glaucoma in Sotos syndrome (cerebral gigantism).

Abstract

PURPOSE

To report a patient with unilateral glaucoma associated with Sotos syndrome. Sotos syndrome (cerebral gigantism) is a disorder of growth and development with characteristic facial changes and normal endocrine function. Ocular manifestations may also include megalocornea, iris hypoplasia, cataracts, megalophthalmos, strabismus, nystagmus, and retinal dystrophy.

METHODS

Case report. A 50 year-old man with the clinical features of Sotos syndrome presented with complaints of decreased vision in the left eye.

RESULTS

Ophthalmologic examination revealed bilateral megalocornea, megalophthalmos, iris hypoplasia and transillumination defects, cataracts, and unilateral glaucoma. Intraocular pressure was lowered, and visual field loss was stabilized with topical medications.

CONCLUSION

Sotos syndrome patients should be examined routinely to allow for early detection and treatment of potential ocular problems, including glaucoma.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida, USA. dryen@prodigy.net

    ,

    Source

    American journal of ophthalmology 130:6 2000 Dec pg 851-3

    MeSH

    Abnormalities, Multiple
    Brain
    Cataract
    Cornea
    Eye Abnormalities
    Gigantism
    Glaucoma
    Humans
    Intraocular Pressure
    Iris
    Male
    Middle Aged
    Syndrome
    Visual Fields

    Pub Type(s)

    Case Reports
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    11124318

    Citation

    Yen, M T., et al. "Unilateral Glaucoma in Sotos Syndrome (cerebral Gigantism)." American Journal of Ophthalmology, vol. 130, no. 6, 2000, pp. 851-3.
    Yen MT, Gedde SJ, Flynn JT. Unilateral glaucoma in Sotos syndrome (cerebral gigantism). Am J Ophthalmol. 2000;130(6):851-3.
    Yen, M. T., Gedde, S. J., & Flynn, J. T. (2000). Unilateral glaucoma in Sotos syndrome (cerebral gigantism). American Journal of Ophthalmology, 130(6), pp. 851-3.
    Yen MT, Gedde SJ, Flynn JT. Unilateral Glaucoma in Sotos Syndrome (cerebral Gigantism). Am J Ophthalmol. 2000;130(6):851-3. PubMed PMID: 11124318.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Unilateral glaucoma in Sotos syndrome (cerebral gigantism). AU - Yen,M T, AU - Gedde,S J, AU - Flynn,J T, PY - 2000/12/22/pubmed PY - 2001/2/28/medline PY - 2000/12/22/entrez SP - 851 EP - 3 JF - American journal of ophthalmology JO - Am. J. Ophthalmol. VL - 130 IS - 6 N2 - PURPOSE: To report a patient with unilateral glaucoma associated with Sotos syndrome. Sotos syndrome (cerebral gigantism) is a disorder of growth and development with characteristic facial changes and normal endocrine function. Ocular manifestations may also include megalocornea, iris hypoplasia, cataracts, megalophthalmos, strabismus, nystagmus, and retinal dystrophy. METHODS: Case report. A 50 year-old man with the clinical features of Sotos syndrome presented with complaints of decreased vision in the left eye. RESULTS: Ophthalmologic examination revealed bilateral megalocornea, megalophthalmos, iris hypoplasia and transillumination defects, cataracts, and unilateral glaucoma. Intraocular pressure was lowered, and visual field loss was stabilized with topical medications. CONCLUSION: Sotos syndrome patients should be examined routinely to allow for early detection and treatment of potential ocular problems, including glaucoma. SN - 0002-9394 UR - https://www.unboundmedicine.com/medline/citation/11124318/Unilateral_glaucoma_in_Sotos_syndrome__cerebral_gigantism__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002939400006401 DB - PRIME DP - Unbound Medicine ER -