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Plasma adrenaline and serum gastrin: studies in insulin-induced hypoglycemia and after adrenaline infusions.
Gastroenterology. 1975 Mar; 68(3):455-60.G

Abstract

Serum gastrin, plasma adrenaline, and blood glucose concentration were measured in 12 patients during insulin-induced hypoglycemia. Six patients had a duodenal ulcer, and 6 patients, 2 to 3 months earlier, had undergone a selective gastric vagotomy due to a duodenal ulcer. The lowest blood glucose concentration was obtained 30 min after the injection of insulin. The rise in plasma adrenaline showed a significant correlation with the degree of hypoglycemia attained. Serum gastrin was approximately doubled in both groups of subjects during the test. There was a strong correlation between rise in serum gastrin expressed in percentage of the basal value and the plasma adrenaline during hypoglycemia. In other experiments, adrenaline was infused intravenously in normal subjects in amounts (6 mug per min for 20 min) resulting in plasma concentrations comparable to those seen during the infusion. It is concluded that adrenaline is a hitherto little recognized factor influencing the gastrin response to hypoglycemia.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1112448

Citation

Brandsborg, O, et al. "Plasma Adrenaline and Serum Gastrin: Studies in Insulin-induced Hypoglycemia and After Adrenaline Infusions." Gastroenterology, vol. 68, no. 3, 1975, pp. 455-60.
Brandsborg O, Brandsborg M, Christensen NJ. Plasma adrenaline and serum gastrin: studies in insulin-induced hypoglycemia and after adrenaline infusions. Gastroenterology. 1975;68(3):455-60.
Brandsborg, O., Brandsborg, M., & Christensen, N. J. (1975). Plasma adrenaline and serum gastrin: studies in insulin-induced hypoglycemia and after adrenaline infusions. Gastroenterology, 68(3), 455-60.
Brandsborg O, Brandsborg M, Christensen NJ. Plasma Adrenaline and Serum Gastrin: Studies in Insulin-induced Hypoglycemia and After Adrenaline Infusions. Gastroenterology. 1975;68(3):455-60. PubMed PMID: 1112448.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma adrenaline and serum gastrin: studies in insulin-induced hypoglycemia and after adrenaline infusions. AU - Brandsborg,O, AU - Brandsborg,M, AU - Christensen,N J, PY - 1975/3/1/pubmed PY - 1975/3/1/medline PY - 1975/3/1/entrez SP - 455 EP - 60 JF - Gastroenterology JO - Gastroenterology VL - 68 IS - 3 N2 - Serum gastrin, plasma adrenaline, and blood glucose concentration were measured in 12 patients during insulin-induced hypoglycemia. Six patients had a duodenal ulcer, and 6 patients, 2 to 3 months earlier, had undergone a selective gastric vagotomy due to a duodenal ulcer. The lowest blood glucose concentration was obtained 30 min after the injection of insulin. The rise in plasma adrenaline showed a significant correlation with the degree of hypoglycemia attained. Serum gastrin was approximately doubled in both groups of subjects during the test. There was a strong correlation between rise in serum gastrin expressed in percentage of the basal value and the plasma adrenaline during hypoglycemia. In other experiments, adrenaline was infused intravenously in normal subjects in amounts (6 mug per min for 20 min) resulting in plasma concentrations comparable to those seen during the infusion. It is concluded that adrenaline is a hitherto little recognized factor influencing the gastrin response to hypoglycemia. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/1112448/Plasma_adrenaline_and_serum_gastrin:_studies_in_insulin_induced_hypoglycemia_and_after_adrenaline_infusions_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016508575000455 DB - PRIME DP - Unbound Medicine ER -