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Behenic acid is a cholesterol-raising saturated fatty acid in humans.
Am J Clin Nutr 2001; 73(1):41-4AJ

Abstract

BACKGROUND

Dietary behenic acid (22:0) is poorly absorbed. Because of its low bioavailability compared with other fatty acids and because of its very long chain length, the effect of dietary behenic acid (behenate) on serum lipid concentrations in humans is assumed to be neutral.

OBJECTIVE

The objective was to establish the cholesterol-raising potential of behenic acid by comparing the effects on lipid and lipoprotein concentrations of a specially formulated fat enriched with behenic acid with those of palm oil (rich in palmitic acid; 16:0) and high-oleic acid sunflower oil (rich in cis oleic acid; 18:1).

DESIGN

In a randomized, crossover, metabolic-ward study, 7 mildly hypercholesterolemic men were fed 3 natural-food diets supplemented with behenate oil, palm oil, or high-oleic acid sunflower oil. Mean serum lipid and lipoprotein concentrations and plasma triacylglycerol fatty acid composition were determined from fasting blood drawn during the final 4 d of each 3-wk diet period.

RESULTS

Behenate oil produced mean concentrations of total cholesterol (5.87+/-0.8 mmol/L) and LDL cholesterol (4.40+/-0.8 mmol/L) not significantly different from those produced by palm oil (5.84+/-0.7 and 4.42+/-0.7 mmol/L, respectively) but significantly higher than those produced by high-oleic acid sunflower oil (5.12+/-0.5 and 3.70+/-0.6 mmol/L, respectively). There were no significant differences in triacylglycerol or HDL-cholesterol concentrations.

CONCLUSIONS

Despite its low bioavailability compared with oleic acid, behenic acid is a cholesterol-raising fatty acid in humans and is therefore not a suitable substitute for palmitic acid in manufactured triacylglycerols.

Authors+Show Affiliations

Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, and the Dallas Veterans' Affairs Medical Center, 75235-9052, USA. ncater@mednet.swmed.eduNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11124748

Citation

Cater, N B., and M A. Denke. "Behenic Acid Is a Cholesterol-raising Saturated Fatty Acid in Humans." The American Journal of Clinical Nutrition, vol. 73, no. 1, 2001, pp. 41-4.
Cater NB, Denke MA. Behenic acid is a cholesterol-raising saturated fatty acid in humans. Am J Clin Nutr. 2001;73(1):41-4.
Cater, N. B., & Denke, M. A. (2001). Behenic acid is a cholesterol-raising saturated fatty acid in humans. The American Journal of Clinical Nutrition, 73(1), pp. 41-4.
Cater NB, Denke MA. Behenic Acid Is a Cholesterol-raising Saturated Fatty Acid in Humans. Am J Clin Nutr. 2001;73(1):41-4. PubMed PMID: 11124748.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Behenic acid is a cholesterol-raising saturated fatty acid in humans. AU - Cater,N B, AU - Denke,M A, PY - 2000/12/22/pubmed PY - 2001/2/28/medline PY - 2000/12/22/entrez SP - 41 EP - 4 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 73 IS - 1 N2 - BACKGROUND: Dietary behenic acid (22:0) is poorly absorbed. Because of its low bioavailability compared with other fatty acids and because of its very long chain length, the effect of dietary behenic acid (behenate) on serum lipid concentrations in humans is assumed to be neutral. OBJECTIVE: The objective was to establish the cholesterol-raising potential of behenic acid by comparing the effects on lipid and lipoprotein concentrations of a specially formulated fat enriched with behenic acid with those of palm oil (rich in palmitic acid; 16:0) and high-oleic acid sunflower oil (rich in cis oleic acid; 18:1). DESIGN: In a randomized, crossover, metabolic-ward study, 7 mildly hypercholesterolemic men were fed 3 natural-food diets supplemented with behenate oil, palm oil, or high-oleic acid sunflower oil. Mean serum lipid and lipoprotein concentrations and plasma triacylglycerol fatty acid composition were determined from fasting blood drawn during the final 4 d of each 3-wk diet period. RESULTS: Behenate oil produced mean concentrations of total cholesterol (5.87+/-0.8 mmol/L) and LDL cholesterol (4.40+/-0.8 mmol/L) not significantly different from those produced by palm oil (5.84+/-0.7 and 4.42+/-0.7 mmol/L, respectively) but significantly higher than those produced by high-oleic acid sunflower oil (5.12+/-0.5 and 3.70+/-0.6 mmol/L, respectively). There were no significant differences in triacylglycerol or HDL-cholesterol concentrations. CONCLUSIONS: Despite its low bioavailability compared with oleic acid, behenic acid is a cholesterol-raising fatty acid in humans and is therefore not a suitable substitute for palmitic acid in manufactured triacylglycerols. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/11124748/Behenic_acid_is_a_cholesterol_raising_saturated_fatty_acid_in_humans_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/73.1.41 DB - PRIME DP - Unbound Medicine ER -