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Effect of ascorbic acid intake on nonheme-iron absorption from a complete diet.
Am J Clin Nutr 2001; 73(1):93-8AJ

Abstract

BACKGROUND

Ascorbic acid has a pronounced enhancing effect on the absorption of dietary nonheme iron when assessed by feeding single meals to fasting subjects. This contrasts with the negligible effect on iron balance of long-term supplementation with vitamin C.

OBJECTIVE

Our goal was to examine the effect of vitamin C on nonheme-iron absorption from a complete diet rather than from single meals.

DESIGN

Iron absorption from a complete diet was measured during 3 separate dietary periods in 12 subjects by having the subjects ingest a labeled wheat roll with every meal for 5 d. The diet was freely chosen for the first dietary period and was then altered to maximally decrease or increase the dietary intake of vitamin C during the second and third periods.

RESULTS

There was no significant difference in mean iron absorption among the 3 dietary periods despite a range of mean daily intakes of dietary vitamin C of 51-247 mg/d. When absorption values were adjusted for differences in iron status and the 3 absorption periods were pooled, multiple regression analysis indicated that iron absorption correlated negatively with dietary phosphate (P = 0.0005) and positively with ascorbic acid (P = 0.0069) and animal tissue (P = 0.0285).

CONCLUSIONS

The facilitating effect of vitamin C on iron absorption from a complete diet is far less pronounced than that from single meals. These findings may explain why several prior studies did not show a significant effect on iron status of prolonged supplementation with vitamin C.

Authors+Show Affiliations

Department of Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA. jcook1@kumc.eduNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11124756

Citation

Cook, J D., and M B. Reddy. "Effect of Ascorbic Acid Intake On Nonheme-iron Absorption From a Complete Diet." The American Journal of Clinical Nutrition, vol. 73, no. 1, 2001, pp. 93-8.
Cook JD, Reddy MB. Effect of ascorbic acid intake on nonheme-iron absorption from a complete diet. Am J Clin Nutr. 2001;73(1):93-8.
Cook, J. D., & Reddy, M. B. (2001). Effect of ascorbic acid intake on nonheme-iron absorption from a complete diet. The American Journal of Clinical Nutrition, 73(1), pp. 93-8.
Cook JD, Reddy MB. Effect of Ascorbic Acid Intake On Nonheme-iron Absorption From a Complete Diet. Am J Clin Nutr. 2001;73(1):93-8. PubMed PMID: 11124756.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of ascorbic acid intake on nonheme-iron absorption from a complete diet. AU - Cook,J D, AU - Reddy,M B, PY - 2000/12/22/pubmed PY - 2001/2/28/medline PY - 2000/12/22/entrez SP - 93 EP - 8 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 73 IS - 1 N2 - BACKGROUND: Ascorbic acid has a pronounced enhancing effect on the absorption of dietary nonheme iron when assessed by feeding single meals to fasting subjects. This contrasts with the negligible effect on iron balance of long-term supplementation with vitamin C. OBJECTIVE: Our goal was to examine the effect of vitamin C on nonheme-iron absorption from a complete diet rather than from single meals. DESIGN: Iron absorption from a complete diet was measured during 3 separate dietary periods in 12 subjects by having the subjects ingest a labeled wheat roll with every meal for 5 d. The diet was freely chosen for the first dietary period and was then altered to maximally decrease or increase the dietary intake of vitamin C during the second and third periods. RESULTS: There was no significant difference in mean iron absorption among the 3 dietary periods despite a range of mean daily intakes of dietary vitamin C of 51-247 mg/d. When absorption values were adjusted for differences in iron status and the 3 absorption periods were pooled, multiple regression analysis indicated that iron absorption correlated negatively with dietary phosphate (P = 0.0005) and positively with ascorbic acid (P = 0.0069) and animal tissue (P = 0.0285). CONCLUSIONS: The facilitating effect of vitamin C on iron absorption from a complete diet is far less pronounced than that from single meals. These findings may explain why several prior studies did not show a significant effect on iron status of prolonged supplementation with vitamin C. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/11124756/Effect_of_ascorbic_acid_intake_on_nonheme_iron_absorption_from_a_complete_diet_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/73.1.93 DB - PRIME DP - Unbound Medicine ER -