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Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees.
Science. 2000 Dec 22; 290(5500):2303-4.Sci

Abstract

Plasma Abeta42 (amyloid beta42 peptide) is invariably elevated in early-onset familial Alzheimer's disease (AD), and it is also increased in the first-degree relatives of patients with typical late-onset AD (LOAD). To detect LOAD loci that increase Abeta42, we used plasma Abeta42 as a surrogate trait and performed linkage analysis on extended AD pedigrees identified through a LOAD patient with extremely high plasma Abeta. Here, we report linkage to chromosome 10 with a maximal lod score of 3.93 at 81 centimorgans close to D10S1225. Remarkably, linkage to the same region was obtained independently in a genome-wide screen of LOAD sibling pairs. These results provide strong evidence for a novel LOAD locus on chromosome 10 that acts to increase Abeta.

Authors+Show Affiliations

Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11125143

Citation

Ertekin-Taner, N, et al. "Linkage of Plasma Abeta42 to a Quantitative Locus On Chromosome 10 in Late-onset Alzheimer's Disease Pedigrees." Science (New York, N.Y.), vol. 290, no. 5500, 2000, pp. 2303-4.
Ertekin-Taner N, Graff-Radford N, Younkin LH, et al. Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. Science. 2000;290(5500):2303-4.
Ertekin-Taner, N., Graff-Radford, N., Younkin, L. H., Eckman, C., Baker, M., Adamson, J., Ronald, J., Blangero, J., Hutton, M., & Younkin, S. G. (2000). Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. Science (New York, N.Y.), 290(5500), 2303-4.
Ertekin-Taner N, et al. Linkage of Plasma Abeta42 to a Quantitative Locus On Chromosome 10 in Late-onset Alzheimer's Disease Pedigrees. Science. 2000 Dec 22;290(5500):2303-4. PubMed PMID: 11125143.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. AU - Ertekin-Taner,N, AU - Graff-Radford,N, AU - Younkin,L H, AU - Eckman,C, AU - Baker,M, AU - Adamson,J, AU - Ronald,J, AU - Blangero,J, AU - Hutton,M, AU - Younkin,S G, PY - 2000/12/23/pubmed PY - 2001/2/28/medline PY - 2000/12/23/entrez SP - 2303 EP - 4 JF - Science (New York, N.Y.) JO - Science VL - 290 IS - 5500 N2 - Plasma Abeta42 (amyloid beta42 peptide) is invariably elevated in early-onset familial Alzheimer's disease (AD), and it is also increased in the first-degree relatives of patients with typical late-onset AD (LOAD). To detect LOAD loci that increase Abeta42, we used plasma Abeta42 as a surrogate trait and performed linkage analysis on extended AD pedigrees identified through a LOAD patient with extremely high plasma Abeta. Here, we report linkage to chromosome 10 with a maximal lod score of 3.93 at 81 centimorgans close to D10S1225. Remarkably, linkage to the same region was obtained independently in a genome-wide screen of LOAD sibling pairs. These results provide strong evidence for a novel LOAD locus on chromosome 10 that acts to increase Abeta. SN - 0036-8075 UR - https://www.unboundmedicine.com/medline/citation/11125143/Linkage_of_plasma_Abeta42_to_a_quantitative_locus_on_chromosome_10_in_late_onset_Alzheimer's_disease_pedigrees_ L2 - https://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=11125143 DB - PRIME DP - Unbound Medicine ER -