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The effect of isolated soy protein on plasma biomarkers in elderly men with elevated serum prostate specific antigen.
J Urol. 2001 Jan; 165(1):294-300.JU

Abstract

PURPOSE

We performed a randomized double-blind crossover pilot study in elderly men with elevated prostate specific antigen (PSA) on the effects of the daily consumption of 2 soy beverages, each containing 20 gm. of isolated soy protein, on the isoflavone concentration in blood and urine, and on the 3 serum biomarkers cholesterol, PSA and the soluble p105 component of the p185erbB-2 proto-oncogene.

MATERIALS AND METHODS

A total of 34 men supplemented their diet by consuming 1 of 2 soy protein beverages assigned randomly twice daily for a 6-week period. In a second 6-week period they consumed the other soy protein beverage. The beverage ISP+ provided 42 mg. of genistein and 27 mg. of daidzein daily, whereas the other beverage, ISP-, provided only 2.1 and 1.3 mg. of these isoflavones daily, respectively. Blood and 24-hour urine samples were obtained before the study, at 2-week intervals during the study and 2 weeks after study completion.

RESULTS

ISP+ and to a lesser extent ISP- substantially increased the serum concentration and urinary output of the isoflavones and their metabolites. Serum cholesterol was significantly decreased by ISP+ irrespective of the order in which the 2 soy beverages were administered and in apparent correlation with the total isoflavone concentration. There was no significant effect of the soy beverages on serum PSA and p105erbB-2 values.

CONCLUSIONS

This study reveals that short-term exposure of elderly men with elevated serum PSA values to soy protein containing isoflavones decreases serum cholesterol but not the serum biomarkers PSA and p105erbB-2.

Authors+Show Affiliations

Division of Urology, Departments of Surgery, Pathology and Pharmacology and Toxicology, and Biostatistics Unit and Mass Spectrometry Shared Facility, Comprehensive Cancer Center, University of Alabama at Birmingham, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11125428

Citation

Urban, D, et al. "The Effect of Isolated Soy Protein On Plasma Biomarkers in Elderly Men With Elevated Serum Prostate Specific Antigen." The Journal of Urology, vol. 165, no. 1, 2001, pp. 294-300.
Urban D, Irwin W, Kirk M, et al. The effect of isolated soy protein on plasma biomarkers in elderly men with elevated serum prostate specific antigen. J Urol. 2001;165(1):294-300.
Urban, D., Irwin, W., Kirk, M., Markiewicz, M. A., Myers, R., Smith, M., Weiss, H., Grizzle, W. E., & Barnes, S. (2001). The effect of isolated soy protein on plasma biomarkers in elderly men with elevated serum prostate specific antigen. The Journal of Urology, 165(1), 294-300.
Urban D, et al. The Effect of Isolated Soy Protein On Plasma Biomarkers in Elderly Men With Elevated Serum Prostate Specific Antigen. J Urol. 2001;165(1):294-300. PubMed PMID: 11125428.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of isolated soy protein on plasma biomarkers in elderly men with elevated serum prostate specific antigen. AU - Urban,D, AU - Irwin,W, AU - Kirk,M, AU - Markiewicz,M A, AU - Myers,R, AU - Smith,M, AU - Weiss,H, AU - Grizzle,W E, AU - Barnes,S, PY - 2000/12/23/pubmed PY - 2001/2/28/medline PY - 2000/12/23/entrez SP - 294 EP - 300 JF - The Journal of urology JO - J. Urol. VL - 165 IS - 1 N2 - PURPOSE: We performed a randomized double-blind crossover pilot study in elderly men with elevated prostate specific antigen (PSA) on the effects of the daily consumption of 2 soy beverages, each containing 20 gm. of isolated soy protein, on the isoflavone concentration in blood and urine, and on the 3 serum biomarkers cholesterol, PSA and the soluble p105 component of the p185erbB-2 proto-oncogene. MATERIALS AND METHODS: A total of 34 men supplemented their diet by consuming 1 of 2 soy protein beverages assigned randomly twice daily for a 6-week period. In a second 6-week period they consumed the other soy protein beverage. The beverage ISP+ provided 42 mg. of genistein and 27 mg. of daidzein daily, whereas the other beverage, ISP-, provided only 2.1 and 1.3 mg. of these isoflavones daily, respectively. Blood and 24-hour urine samples were obtained before the study, at 2-week intervals during the study and 2 weeks after study completion. RESULTS: ISP+ and to a lesser extent ISP- substantially increased the serum concentration and urinary output of the isoflavones and their metabolites. Serum cholesterol was significantly decreased by ISP+ irrespective of the order in which the 2 soy beverages were administered and in apparent correlation with the total isoflavone concentration. There was no significant effect of the soy beverages on serum PSA and p105erbB-2 values. CONCLUSIONS: This study reveals that short-term exposure of elderly men with elevated serum PSA values to soy protein containing isoflavones decreases serum cholesterol but not the serum biomarkers PSA and p105erbB-2. SN - 0022-5347 UR - https://www.unboundmedicine.com/medline/citation/11125428/The_effect_of_isolated_soy_protein_on_plasma_biomarkers_in_elderly_men_with_elevated_serum_prostate_specific_antigen_ L2 - https://www.jurology.com/doi/full/10.1097/00005392-200101000-00082?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -