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[Transthyretin levels in serum and cerebrospinal fluid sustain the nutrio-viral hypothesis of the Cuban epidemic neuropathy].
Rev Neurol. 2000 Nov 1-15; 31(9):801-4.RN

Abstract

INTRODUCTION

Transthyretin is considered an excellent marker for monitoring nutritional status in serum. In cerebrospinal fluid it is synthesized by chroroid plexus. Cuban epidemic neuropathy is an emergent disease with a hypothetically viral and nutritional origin.

OBJECTIVE

To know the behavior of this transport molecule in serum and cerebrospinal fluid in patients with Cuban epidemic neuropathy.

PATIENTS AND METHODS

Serum and cerebrospinal fluid was quantified in 11 patients with Cuban epidemic neuropathy, eight patients suffering from other neuropathies and 15 patients with Down's syndrome and 10 patients with Alzheimer's disease.

RESULTS

Serum transthyretin was diminished in patients with Cuban epidemic neuropathy, other neuropathies and Alzheimer's disease. Down's syndrome patients had significantly higher transthyretin levels in comparison with Cuban epidemic neuropathy and Alzheimer's disease. Cerebrospinal fluid transthyretin was significantly increased in patients with Cuban epidemic neuropathy in comparison with the normal values and with Alzheimer's disease patients whose values were settled below the normal values.

CONCLUSIONS

The decrement of serum transthyretin in Cuban epidemic neuropathy indicates malnutrition and its higher levels in cerebrospinal fluid also indicate a viral infection. These findings support the nutrio-viral hypothesis of the disease.

Authors+Show Affiliations

Dorta-Contreras AJ
Laboratorio de Neuroinmunología, Hospital Pediátrico San Miguel, Habana, Cuba. adorta@infomed.sld.cu
Barshatzky M
No affiliation info available
Noris-García E
No affiliation info available
Serrano-Sánchez T
No affiliation info available

MeSH

AdolescentAdultAlzheimer DiseaseBiomarkersChildCubaDown SyndromeHumansMiddle AgedNervous System DiseasesPrealbumin

Pub Type(s)

English Abstract
Journal Article

Language

spa

PubMed ID

11127078

Citation

Dorta-Contreras, A J., et al. "[Transthyretin Levels in Serum and Cerebrospinal Fluid Sustain the Nutrio-viral Hypothesis of the Cuban Epidemic Neuropathy]." Revista De Neurologia, vol. 31, no. 9, 2000, pp. 801-4.
Dorta-Contreras AJ, Barshatzky M, Noris-García E, et al. [Transthyretin levels in serum and cerebrospinal fluid sustain the nutrio-viral hypothesis of the Cuban epidemic neuropathy]. Rev Neurol. 2000;31(9):801-4.
Dorta-Contreras, A. J., Barshatzky, M., Noris-García, E., & Serrano-Sánchez, T. (2000). [Transthyretin levels in serum and cerebrospinal fluid sustain the nutrio-viral hypothesis of the Cuban epidemic neuropathy]. Revista De Neurologia, 31(9), 801-4.
Dorta-Contreras AJ, et al. [Transthyretin Levels in Serum and Cerebrospinal Fluid Sustain the Nutrio-viral Hypothesis of the Cuban Epidemic Neuropathy]. Rev Neurol. 2000 Nov 1-15;31(9):801-4. PubMed PMID: 11127078.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Transthyretin levels in serum and cerebrospinal fluid sustain the nutrio-viral hypothesis of the Cuban epidemic neuropathy]. AU - Dorta-Contreras,A J, AU - Barshatzky,M, AU - Noris-García,E, AU - Serrano-Sánchez,T, PY - 2000/12/29/pubmed PY - 2001/2/28/medline PY - 2000/12/29/entrez SP - 801 EP - 4 JF - Revista de neurologia JO - Rev Neurol VL - 31 IS - 9 N2 - INTRODUCTION: Transthyretin is considered an excellent marker for monitoring nutritional status in serum. In cerebrospinal fluid it is synthesized by chroroid plexus. Cuban epidemic neuropathy is an emergent disease with a hypothetically viral and nutritional origin. OBJECTIVE: To know the behavior of this transport molecule in serum and cerebrospinal fluid in patients with Cuban epidemic neuropathy. PATIENTS AND METHODS: Serum and cerebrospinal fluid was quantified in 11 patients with Cuban epidemic neuropathy, eight patients suffering from other neuropathies and 15 patients with Down's syndrome and 10 patients with Alzheimer's disease. RESULTS: Serum transthyretin was diminished in patients with Cuban epidemic neuropathy, other neuropathies and Alzheimer's disease. Down's syndrome patients had significantly higher transthyretin levels in comparison with Cuban epidemic neuropathy and Alzheimer's disease. Cerebrospinal fluid transthyretin was significantly increased in patients with Cuban epidemic neuropathy in comparison with the normal values and with Alzheimer's disease patients whose values were settled below the normal values. CONCLUSIONS: The decrement of serum transthyretin in Cuban epidemic neuropathy indicates malnutrition and its higher levels in cerebrospinal fluid also indicate a viral infection. These findings support the nutrio-viral hypothesis of the disease. SN - 0210-0010 UR - https://www.unboundmedicine.com/medline/citation/11127078/[Transthyretin_levels_in_serum_and_cerebrospinal_fluid_sustain_the_nutrio_viral_hypothesis_of_the_Cuban_epidemic_neuropathy]_ DB - PRIME DP - Unbound Medicine ER -