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Anti-endomysial and anti-gliadin antibodies in screening for coeliac disease in children at greater risk of developing coeliac disease.
N Z Med J 2000; 113(1119):412-3NZ

Abstract

AIMS

To determine the prevalence of coeliac disease in selected groups of children presenting to a paediatric department.

METHODS

Children presenting to the Paediatric Department at Christchurch Hospital were enrolled upon identification of one or more factors associated with increased risk of coeliac disease. All subjects were screened with anti-endomysial antibody and antigliadin antibody tests. Those children with positive tests underwent small bowel biopsy.

RESULTS

36 of 153 children had abnormal antibody tests. Seven (4.5%) of 34 children who underwent small bowel biopsies were found to have histological findings consistent with coeliac disease. Five of these children had presented with symptoms not classically ascribed to coeliac disease (failure to gain weight or non-specific abdominal pain).

CONCLUSIONS

The possibility of coeliac disease should be considered in children with atypical symptoms and the diagnosis excluded by appropriate testing. Recognition of the variable presentations associated with coeliac disease in children is clinically relevant.

Authors+Show Affiliations

Paediatric Department, Christchurch Hospital.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11127356

Citation

Day, A S., et al. "Anti-endomysial and Anti-gliadin Antibodies in Screening for Coeliac Disease in Children at Greater Risk of Developing Coeliac Disease." The New Zealand Medical Journal, vol. 113, no. 1119, 2000, pp. 412-3.
Day AS, Cook HB, Whitehead M, et al. Anti-endomysial and anti-gliadin antibodies in screening for coeliac disease in children at greater risk of developing coeliac disease. N Z Med J. 2000;113(1119):412-3.
Day, A. S., Cook, H. B., Whitehead, M., & Abbott, G. D. (2000). Anti-endomysial and anti-gliadin antibodies in screening for coeliac disease in children at greater risk of developing coeliac disease. The New Zealand Medical Journal, 113(1119), pp. 412-3.
Day AS, et al. Anti-endomysial and Anti-gliadin Antibodies in Screening for Coeliac Disease in Children at Greater Risk of Developing Coeliac Disease. N Z Med J. 2000 Oct 13;113(1119):412-3. PubMed PMID: 11127356.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-endomysial and anti-gliadin antibodies in screening for coeliac disease in children at greater risk of developing coeliac disease. AU - Day,A S, AU - Cook,H B, AU - Whitehead,M, AU - Abbott,G D, PY - 2000/12/29/pubmed PY - 2001/2/28/medline PY - 2000/12/29/entrez SP - 412 EP - 3 JF - The New Zealand medical journal JO - N. Z. Med. J. VL - 113 IS - 1119 N2 - AIMS: To determine the prevalence of coeliac disease in selected groups of children presenting to a paediatric department. METHODS: Children presenting to the Paediatric Department at Christchurch Hospital were enrolled upon identification of one or more factors associated with increased risk of coeliac disease. All subjects were screened with anti-endomysial antibody and antigliadin antibody tests. Those children with positive tests underwent small bowel biopsy. RESULTS: 36 of 153 children had abnormal antibody tests. Seven (4.5%) of 34 children who underwent small bowel biopsies were found to have histological findings consistent with coeliac disease. Five of these children had presented with symptoms not classically ascribed to coeliac disease (failure to gain weight or non-specific abdominal pain). CONCLUSIONS: The possibility of coeliac disease should be considered in children with atypical symptoms and the diagnosis excluded by appropriate testing. Recognition of the variable presentations associated with coeliac disease in children is clinically relevant. SN - 0028-8446 UR - https://www.unboundmedicine.com/medline/citation/11127356/Anti_endomysial_and_anti_gliadin_antibodies_in_screening_for_coeliac_disease_in_children_at_greater_risk_of_developing_coeliac_disease_ L2 - https://medlineplus.gov/celiacdisease.html DB - PRIME DP - Unbound Medicine ER -