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Can bone turnover markers correlate bone mass at the hip and spine according to menopausal period?
Arch Gynecol Obstet 2000; 264(3):119-23AG

Abstract

Changes in bone turnover with years since menopause (YSM) are responsible for bone loss and play a major role in osteoporosis. Although single measurements of the bone turnover marker appear unlikely to be clinically useful in predicting bone mineral density, the usefulness of these measurements in relation to the YSM has not been well established. The establishment of this relationship was the aim of this study. To address this issue, we have measured a battery of sensitive and specific markers of bone turnover in 272 women postmenopausal from -5 to 15 a, and the data was correlated with bone mineral density (BMD) at different skeletal sites measured utilizing dual-energy X-ray absorptiometry (DXA). Bone formation was assessed by serum osteocalcin (OC), and bone resorption by Pyr and D-pyr. The three markers and BMD were compared between the groups (YSM). Among the three markers, only Pyr exhibited a significant difference between pre and postmenopausal groups. In the aspect of correlation between bone turnover marker and BMD according to the groups (YSM), we found negative strong correlations between the BMD of lumbar spine (L2-4) vs. Pyr (P=0.01, r=-0.75) in the premenopausal group (-5 approximately 0 YSM), and we found negative correlation between the BMD of L2-4 vs. osteocalcin (P=0.05, r=-0.2 and P=0.01, r=-4).44) in the postmenopause groups (0 approximately 5 and 5 approximately 10 YSM). We concluded that Pyr in women -5 approximately 0 YSM and osteocalcin in women 0 approximately 10 YSM displayed negative correlation with BMD of L2-4.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, KangNam St Mary's Hospital, Seoul. kchung@cmc.cuk.ac.krNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11129509

Citation

Chung, K W., et al. "Can Bone Turnover Markers Correlate Bone Mass at the Hip and Spine According to Menopausal Period?" Archives of Gynecology and Obstetrics, vol. 264, no. 3, 2000, pp. 119-23.
Chung KW, Kim MR, Yoo SW, et al. Can bone turnover markers correlate bone mass at the hip and spine according to menopausal period? Arch Gynecol Obstet. 2000;264(3):119-23.
Chung, K. W., Kim, M. R., Yoo, S. W., Kwon, D. J., Lim, Y. T., Kim, J. H., & Lee, J. W. (2000). Can bone turnover markers correlate bone mass at the hip and spine according to menopausal period? Archives of Gynecology and Obstetrics, 264(3), pp. 119-23.
Chung KW, et al. Can Bone Turnover Markers Correlate Bone Mass at the Hip and Spine According to Menopausal Period. Arch Gynecol Obstet. 2000;264(3):119-23. PubMed PMID: 11129509.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Can bone turnover markers correlate bone mass at the hip and spine according to menopausal period? AU - Chung,K W, AU - Kim,M R, AU - Yoo,S W, AU - Kwon,D J, AU - Lim,Y T, AU - Kim,J H, AU - Lee,J W, PY - 2000/12/29/pubmed PY - 2001/3/3/medline PY - 2000/12/29/entrez SP - 119 EP - 23 JF - Archives of gynecology and obstetrics JO - Arch. Gynecol. Obstet. VL - 264 IS - 3 N2 - Changes in bone turnover with years since menopause (YSM) are responsible for bone loss and play a major role in osteoporosis. Although single measurements of the bone turnover marker appear unlikely to be clinically useful in predicting bone mineral density, the usefulness of these measurements in relation to the YSM has not been well established. The establishment of this relationship was the aim of this study. To address this issue, we have measured a battery of sensitive and specific markers of bone turnover in 272 women postmenopausal from -5 to 15 a, and the data was correlated with bone mineral density (BMD) at different skeletal sites measured utilizing dual-energy X-ray absorptiometry (DXA). Bone formation was assessed by serum osteocalcin (OC), and bone resorption by Pyr and D-pyr. The three markers and BMD were compared between the groups (YSM). Among the three markers, only Pyr exhibited a significant difference between pre and postmenopausal groups. In the aspect of correlation between bone turnover marker and BMD according to the groups (YSM), we found negative strong correlations between the BMD of lumbar spine (L2-4) vs. Pyr (P=0.01, r=-0.75) in the premenopausal group (-5 approximately 0 YSM), and we found negative correlation between the BMD of L2-4 vs. osteocalcin (P=0.05, r=-0.2 and P=0.01, r=-4).44) in the postmenopause groups (0 approximately 5 and 5 approximately 10 YSM). We concluded that Pyr in women -5 approximately 0 YSM and osteocalcin in women 0 approximately 10 YSM displayed negative correlation with BMD of L2-4. SN - 0932-0067 UR - https://www.unboundmedicine.com/medline/citation/11129509/Can_bone_turnover_markers_correlate_bone_mass_at_the_hip_and_spine_according_to_menopausal_period L2 - https://dx.doi.org/10.1007/s004040000093 DB - PRIME DP - Unbound Medicine ER -