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Effects of ephedrine on the onset time of neuromuscular block and intubating conditions after cisatracurium: preliminary results.
Acta Anaesthesiol Belg. 2000; 51(3):167-71.AA

Abstract

We studied the effects of intravenous ephedrine on the onset time and the intubating conditions 2 min after a bolus dose of cisatracurium (0.15 mg kg-1). Thirty patients anaesthetized with sufentanil and propofol were randomly divided in 2 groups to receive either ephedrine (70 micrograms.kg-1) or saline, 5 s before propofol. Cisatracurium was administered after loss of consciousness. Neuromuscular block was assessed at the adductor pollicis using accelography. Tracheal intubation was performed 2 min after cisatracurium injection and rated as excellent, good, poor or bad. At intubation, neuromuscular block (% height of control T1) was greater in patients receiving ephedrine (36.1 +/- 25.8% vs 57.9 +/- 25.1%) (mean +/- SD). The frequency of excellent intubating conditions was higher after ephedrine (86.6%) than after saline (40.0%). The onset time of cisatracurium was shorter after ephedrine (167 +/- 64.8 s vs 234.9 +/- 63.1 s). Thus, a low dose of ephedrine given before induction of anaesthesia improves the intubating conditions 2 min after 0.15 mg kg-1 cisatracurium and this effect likely relates to a quicker onset of neuromuscular block.

Authors+Show Affiliations

University Department of Anaesthesia and Intensive Care Medicine, CHR de la Citadelle, University Hospital, Liege, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

11129616

Citation

Albert, F, et al. "Effects of Ephedrine On the Onset Time of Neuromuscular Block and Intubating Conditions After Cisatracurium: Preliminary Results." Acta Anaesthesiologica Belgica, vol. 51, no. 3, 2000, pp. 167-71.
Albert F, Hans P, Bitar Y, et al. Effects of ephedrine on the onset time of neuromuscular block and intubating conditions after cisatracurium: preliminary results. Acta Anaesthesiol Belg. 2000;51(3):167-71.
Albert, F., Hans, P., Bitar, Y., Brichant, J. F., Dewandre, P. Y., & Lamy, M. (2000). Effects of ephedrine on the onset time of neuromuscular block and intubating conditions after cisatracurium: preliminary results. Acta Anaesthesiologica Belgica, 51(3), 167-71.
Albert F, et al. Effects of Ephedrine On the Onset Time of Neuromuscular Block and Intubating Conditions After Cisatracurium: Preliminary Results. Acta Anaesthesiol Belg. 2000;51(3):167-71. PubMed PMID: 11129616.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of ephedrine on the onset time of neuromuscular block and intubating conditions after cisatracurium: preliminary results. AU - Albert,F, AU - Hans,P, AU - Bitar,Y, AU - Brichant,J F, AU - Dewandre,P Y, AU - Lamy,M, PY - 2000/12/29/pubmed PY - 2001/3/3/medline PY - 2000/12/29/entrez SP - 167 EP - 71 JF - Acta anaesthesiologica Belgica JO - Acta Anaesthesiol Belg VL - 51 IS - 3 N2 - We studied the effects of intravenous ephedrine on the onset time and the intubating conditions 2 min after a bolus dose of cisatracurium (0.15 mg kg-1). Thirty patients anaesthetized with sufentanil and propofol were randomly divided in 2 groups to receive either ephedrine (70 micrograms.kg-1) or saline, 5 s before propofol. Cisatracurium was administered after loss of consciousness. Neuromuscular block was assessed at the adductor pollicis using accelography. Tracheal intubation was performed 2 min after cisatracurium injection and rated as excellent, good, poor or bad. At intubation, neuromuscular block (% height of control T1) was greater in patients receiving ephedrine (36.1 +/- 25.8% vs 57.9 +/- 25.1%) (mean +/- SD). The frequency of excellent intubating conditions was higher after ephedrine (86.6%) than after saline (40.0%). The onset time of cisatracurium was shorter after ephedrine (167 +/- 64.8 s vs 234.9 +/- 63.1 s). Thus, a low dose of ephedrine given before induction of anaesthesia improves the intubating conditions 2 min after 0.15 mg kg-1 cisatracurium and this effect likely relates to a quicker onset of neuromuscular block. SN - 0001-5164 UR - https://www.unboundmedicine.com/medline/citation/11129616/Effects_of_ephedrine_on_the_onset_time_of_neuromuscular_block_and_intubating_conditions_after_cisatracurium:_preliminary_results_ DB - PRIME DP - Unbound Medicine ER -