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Validity of a computer-assisted neurobehavioral test battery in toxicant encephalopathy.
Neurotoxicology. 2000 Oct; 21(5):703-14.N

Abstract

The computer-assisted Neurobehavioral Evaluation System 2 (NES2) test battery provides an efficient method of measuring neurobehavioral effects in epidemiological studies, and a newer computer-assisted battery, NES3, has been developed to assist in neuropsychological assessment. This study assesses the validity of some NES2 and NES3 tests in patients diagnosed with toxicant encephalopathy (TE) following exposure to lead or to mixed solvents. This information can be used to improve the interpretation of NES test results in research studies and clinical evaluations examining central nervous system function. Performance on a battery of computer-assisted tests, consisting of several NES2 and NES3 tasks, by persons diagnosed with TE was compared to that of control subjects to determine if performance differences reflected a priori hypothesized brain-behavior relationships. Performance on the NES2 and NES3 tests was also correlated with performance on analogous standard neuropsychological tests. Significant performance differences between the patient cases and controls were observed in most of the predicted domains on the NES tests. Overall, moderate correlations were obtained between standard neuropsychological tests and NES2 and NES3 tests from the same functional domains. The results suggest that a test battery composed of NES2 and NES3 tests can identify clinically significant performance deficits in solvent-exposed patients who have been diagnosed with TE using traditional clinical neuropsychological test methods. The results with lead-exposed TE patients are less robust. Possible explanations for these differences are discussed.

Authors+Show Affiliations

Proctor SP
Boston Environmental Hazards Center, VA Boston Healthcare System, MA 02130, USA. sproctor@bu.edu
Letz R
No affiliation info available
White RF
No affiliation info available

MeSH

AdultAffectAttentionCentral Nervous System DiseasesDiagnosis, Computer-AssistedDiagnosis, DifferentialFemaleHumansLead PoisoningMaleMemoryMiddle AgedMotor ActivityNeuropsychological TestsNeurotoxicity SyndromesOccupational DiseasesOccupational ExposureReference ValuesReproducibility of ResultsSolventsWechsler Scales

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11130274

Citation

Proctor, S P., et al. "Validity of a Computer-assisted Neurobehavioral Test Battery in Toxicant Encephalopathy." Neurotoxicology, vol. 21, no. 5, 2000, pp. 703-14.
Proctor SP, Letz R, White RF. Validity of a computer-assisted neurobehavioral test battery in toxicant encephalopathy. Neurotoxicology. 2000;21(5):703-14.
Proctor, S. P., Letz, R., & White, R. F. (2000). Validity of a computer-assisted neurobehavioral test battery in toxicant encephalopathy. Neurotoxicology, 21(5), 703-14.
Proctor SP, Letz R, White RF. Validity of a Computer-assisted Neurobehavioral Test Battery in Toxicant Encephalopathy. Neurotoxicology. 2000;21(5):703-14. PubMed PMID: 11130274.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Validity of a computer-assisted neurobehavioral test battery in toxicant encephalopathy. AU - Proctor,S P, AU - Letz,R, AU - White,R F, PY - 2000/12/29/pubmed PY - 2001/3/7/medline PY - 2000/12/29/entrez SP - 703 EP - 14 JF - Neurotoxicology JO - Neurotoxicology VL - 21 IS - 5 N2 - The computer-assisted Neurobehavioral Evaluation System 2 (NES2) test battery provides an efficient method of measuring neurobehavioral effects in epidemiological studies, and a newer computer-assisted battery, NES3, has been developed to assist in neuropsychological assessment. This study assesses the validity of some NES2 and NES3 tests in patients diagnosed with toxicant encephalopathy (TE) following exposure to lead or to mixed solvents. This information can be used to improve the interpretation of NES test results in research studies and clinical evaluations examining central nervous system function. Performance on a battery of computer-assisted tests, consisting of several NES2 and NES3 tasks, by persons diagnosed with TE was compared to that of control subjects to determine if performance differences reflected a priori hypothesized brain-behavior relationships. Performance on the NES2 and NES3 tests was also correlated with performance on analogous standard neuropsychological tests. Significant performance differences between the patient cases and controls were observed in most of the predicted domains on the NES tests. Overall, moderate correlations were obtained between standard neuropsychological tests and NES2 and NES3 tests from the same functional domains. The results suggest that a test battery composed of NES2 and NES3 tests can identify clinically significant performance deficits in solvent-exposed patients who have been diagnosed with TE using traditional clinical neuropsychological test methods. The results with lead-exposed TE patients are less robust. Possible explanations for these differences are discussed. SN - 0161-813X UR - https://www.unboundmedicine.com/medline/citation/11130274/Validity_of_a_computer_assisted_neurobehavioral_test_battery_in_toxicant_encephalopathy_ L2 - https://medlineplus.gov/leadpoisoning.html DB - PRIME DP - Unbound Medicine ER -