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Effect of blood pressure and physical activity on carotid artery intima-media thickness in stage 1 hypertensives and controls.
Am J Hypertens 2000; 13(12):1256-62AJ

Abstract

The aim of the study was to investigate whether hypertension and physical training induce parallel changes in the arterial wall. Ninety-seven never-treated stage 1 hypertensive patients (HT) (systolic blood pressure 140 to 159 mm Hg or diastolic blood pressure 90 to 99 mm Hg) aged 18 to 45 years taking part in the Hypertension and Ambulatory Recording Venetia Study and 27 normotensive volunteers (NT) aged 30 +/- 9 years were studied. Data on physical or sports activity were collected and scored, and target organ involvement was investigated by assessing microalbuminuria, echocardiography, and carotid ultrasound study. The carotid arteries were examined according to the Atherosclerosis Risk in Communities protocol. Mean (m-IMT) and maximal (M-IMT) carotid intima-media thickness were measured at end-diastole in the far wall common carotid artery, in the bulb and internal carotid artery, in the lateral and posterior projection, averaging the left and right sides. A comparable level of physical activity was present in HT patients and NT subjects. Twenty-four-hour blood pressure and blood lipid levels, as well as target organ damage, were similar in physically active and sedentary HT. The m-IMT of the common carotid was greater in sedentary HT than in sedentary NT, as well as in active than in sedentary NT. The m-IMT of the internal carotid artery was also greater in active HT than in active NT, as well as in active than in sedentary HT. In logistic regression, comparing the first and fourth quartile of m-IMT, scored physical activity was a predictor of m-IMT in the internal carotid artery. No statistical interaction was found between physical activity and hypertension, indicating that these two items have a cumulative effect and act independently of each other. Sedentary HT had significantly greater levels of M-IMT than sedentary NT in all sites but the bulbs; in the internal and common carotid arteries, HT exercisers had significantly greater M-IMT than NT exercisers. Therefore, physical activity appears to be an early independent predictor of carotid wall thickness. This factor should be taken into consideration in population-based studies aimed at investigating supraortic vessels as it can act as a confounder.

Authors+Show Affiliations

Department of Clinical and Experimental Medicine, University of Padova, Italy. casiglia@ux1.unipd.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11130768

Citation

Casiglia, E, et al. "Effect of Blood Pressure and Physical Activity On Carotid Artery Intima-media Thickness in Stage 1 Hypertensives and Controls." American Journal of Hypertension, vol. 13, no. 12, 2000, pp. 1256-62.
Casiglia E, Palatini P, Da Ros S, et al. Effect of blood pressure and physical activity on carotid artery intima-media thickness in stage 1 hypertensives and controls. Am J Hypertens. 2000;13(12):1256-62.
Casiglia, E., Palatini, P., Da Ros, S., Pagliara, V., Puato, M., Dorigatti, F., & Pauletto, P. (2000). Effect of blood pressure and physical activity on carotid artery intima-media thickness in stage 1 hypertensives and controls. American Journal of Hypertension, 13(12), pp. 1256-62.
Casiglia E, et al. Effect of Blood Pressure and Physical Activity On Carotid Artery Intima-media Thickness in Stage 1 Hypertensives and Controls. Am J Hypertens. 2000;13(12):1256-62. PubMed PMID: 11130768.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of blood pressure and physical activity on carotid artery intima-media thickness in stage 1 hypertensives and controls. AU - Casiglia,E, AU - Palatini,P, AU - Da Ros,S, AU - Pagliara,V, AU - Puato,M, AU - Dorigatti,F, AU - Pauletto,P, PY - 2000/12/29/pubmed PY - 2001/3/3/medline PY - 2000/12/29/entrez SP - 1256 EP - 62 JF - American journal of hypertension JO - Am. J. Hypertens. VL - 13 IS - 12 N2 - The aim of the study was to investigate whether hypertension and physical training induce parallel changes in the arterial wall. Ninety-seven never-treated stage 1 hypertensive patients (HT) (systolic blood pressure 140 to 159 mm Hg or diastolic blood pressure 90 to 99 mm Hg) aged 18 to 45 years taking part in the Hypertension and Ambulatory Recording Venetia Study and 27 normotensive volunteers (NT) aged 30 +/- 9 years were studied. Data on physical or sports activity were collected and scored, and target organ involvement was investigated by assessing microalbuminuria, echocardiography, and carotid ultrasound study. The carotid arteries were examined according to the Atherosclerosis Risk in Communities protocol. Mean (m-IMT) and maximal (M-IMT) carotid intima-media thickness were measured at end-diastole in the far wall common carotid artery, in the bulb and internal carotid artery, in the lateral and posterior projection, averaging the left and right sides. A comparable level of physical activity was present in HT patients and NT subjects. Twenty-four-hour blood pressure and blood lipid levels, as well as target organ damage, were similar in physically active and sedentary HT. The m-IMT of the common carotid was greater in sedentary HT than in sedentary NT, as well as in active than in sedentary NT. The m-IMT of the internal carotid artery was also greater in active HT than in active NT, as well as in active than in sedentary HT. In logistic regression, comparing the first and fourth quartile of m-IMT, scored physical activity was a predictor of m-IMT in the internal carotid artery. No statistical interaction was found between physical activity and hypertension, indicating that these two items have a cumulative effect and act independently of each other. Sedentary HT had significantly greater levels of M-IMT than sedentary NT in all sites but the bulbs; in the internal and common carotid arteries, HT exercisers had significantly greater M-IMT than NT exercisers. Therefore, physical activity appears to be an early independent predictor of carotid wall thickness. This factor should be taken into consideration in population-based studies aimed at investigating supraortic vessels as it can act as a confounder. SN - 0895-7061 UR - https://www.unboundmedicine.com/medline/citation/11130768/Effect_of_blood_pressure_and_physical_activity_on_carotid_artery_intima_media_thickness_in_stage_1_hypertensives_and_controls_ L2 - https://academic.oup.com/ajh/article-lookup/doi/10.1016/s0895-7061(00)01211-5 DB - PRIME DP - Unbound Medicine ER -