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Decreased depressor response mediated by calcitonin gene-related peptide (CGRP)-containing vasodilator nerves to spinal cord stimulation and levels of CGRP mRNA of the dorsal root ganglia in spontaneously hypertensive rats.
Hypertens Res. 2000 Nov; 23(6):693-9.HR

Abstract

The depressor response to electrical stimulation of the spinal cord and the level of calcitonin gene-related peptide (CGRP) mRNA in the dorsal root ganglion (DRG) in the spontaneously hypertensive rat (SHR) was compared with the normotensive Wistar Kyoto rat (WKY) and Wistar rat (WR). The animals were pithed by inserting a stainless-steel rod into the spinal cord. Pithed rats were treated with hexamethonium (2 mg/kg/min i.v.) to block autonomic outflow, and mean arterial blood pressure (MBP) was maintained at approximately 100 mmHg with continuous infusion of methoxamine (10 to 15 microg/kg/min i.v.). Electrical stimulation (2 and 4 Hz for 30 s) of the lower thoracic spinal cord (T9-12) via the pithing rod caused a frequency-dependent depressor response without a change in heart rate. The depressor response to spinal cord stimulation was significantly smaller in SHR than in WKY and WR. Long-term treatment of 8 week-old SHR with captopril (0.1% in drinking water) for 7 weeks restored the reduced depressor response to spinal cord stimulation. The level of CGRP mRNA in DRG of SHR was significantly lower than that in WKY. These results suggest that the function of CGRP-containing nerves from the spinal cord decreases in SHR and captopril treatment prevents its reduction.

Authors+Show Affiliations

Department of Clinical Pharmaceutical Science, Graduate School of Natural Science and Technology, Okayama University, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11131283

Citation

Kawasaki, H, et al. "Decreased Depressor Response Mediated By Calcitonin Gene-related Peptide (CGRP)-containing Vasodilator Nerves to Spinal Cord Stimulation and Levels of CGRP mRNA of the Dorsal Root Ganglia in Spontaneously Hypertensive Rats." Hypertension Research : Official Journal of the Japanese Society of Hypertension, vol. 23, no. 6, 2000, pp. 693-9.
Kawasaki H, Nuki Y, Yamaga N, et al. Decreased depressor response mediated by calcitonin gene-related peptide (CGRP)-containing vasodilator nerves to spinal cord stimulation and levels of CGRP mRNA of the dorsal root ganglia in spontaneously hypertensive rats. Hypertens Res. 2000;23(6):693-9.
Kawasaki, H., Nuki, Y., Yamaga, N., Kurosaki, Y., & Taguchi, T. (2000). Decreased depressor response mediated by calcitonin gene-related peptide (CGRP)-containing vasodilator nerves to spinal cord stimulation and levels of CGRP mRNA of the dorsal root ganglia in spontaneously hypertensive rats. Hypertension Research : Official Journal of the Japanese Society of Hypertension, 23(6), 693-9.
Kawasaki H, et al. Decreased Depressor Response Mediated By Calcitonin Gene-related Peptide (CGRP)-containing Vasodilator Nerves to Spinal Cord Stimulation and Levels of CGRP mRNA of the Dorsal Root Ganglia in Spontaneously Hypertensive Rats. Hypertens Res. 2000;23(6):693-9. PubMed PMID: 11131283.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decreased depressor response mediated by calcitonin gene-related peptide (CGRP)-containing vasodilator nerves to spinal cord stimulation and levels of CGRP mRNA of the dorsal root ganglia in spontaneously hypertensive rats. AU - Kawasaki,H, AU - Nuki,Y, AU - Yamaga,N, AU - Kurosaki,Y, AU - Taguchi,T, PY - 2000/12/29/pubmed PY - 2001/3/3/medline PY - 2000/12/29/entrez SP - 693 EP - 9 JF - Hypertension research : official journal of the Japanese Society of Hypertension JO - Hypertens Res VL - 23 IS - 6 N2 - The depressor response to electrical stimulation of the spinal cord and the level of calcitonin gene-related peptide (CGRP) mRNA in the dorsal root ganglion (DRG) in the spontaneously hypertensive rat (SHR) was compared with the normotensive Wistar Kyoto rat (WKY) and Wistar rat (WR). The animals were pithed by inserting a stainless-steel rod into the spinal cord. Pithed rats were treated with hexamethonium (2 mg/kg/min i.v.) to block autonomic outflow, and mean arterial blood pressure (MBP) was maintained at approximately 100 mmHg with continuous infusion of methoxamine (10 to 15 microg/kg/min i.v.). Electrical stimulation (2 and 4 Hz for 30 s) of the lower thoracic spinal cord (T9-12) via the pithing rod caused a frequency-dependent depressor response without a change in heart rate. The depressor response to spinal cord stimulation was significantly smaller in SHR than in WKY and WR. Long-term treatment of 8 week-old SHR with captopril (0.1% in drinking water) for 7 weeks restored the reduced depressor response to spinal cord stimulation. The level of CGRP mRNA in DRG of SHR was significantly lower than that in WKY. These results suggest that the function of CGRP-containing nerves from the spinal cord decreases in SHR and captopril treatment prevents its reduction. SN - 0916-9636 UR - https://www.unboundmedicine.com/medline/citation/11131283/Decreased_depressor_response_mediated_by_calcitonin_gene_related_peptide__CGRP__containing_vasodilator_nerves_to_spinal_cord_stimulation_and_levels_of_CGRP_mRNA_of_the_dorsal_root_ganglia_in_spontaneously_hypertensive_rats_ L2 - http://joi.jlc.jst.go.jp/JST.Journalarchive/hypres1992/23.693?from=PubMed DB - PRIME DP - Unbound Medicine ER -