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Haemostatic factors and risk of varicose veins and chronic venous insufficiency: Edinburgh Vein Study.

Abstract

Despite much research, the aetiology of venous disease is still poorly understood. Since haemostatic factors are involved in the processes of fibrinolysis and platelet aggregation, it is conceivable that such processes may be implicated in the pathology of varicose veins and chronic venous insufficiency (CVI). The Edinburgh Vein Study examined 1566 men and women aged 18-64 years that were randomly selected from the lists of 12 general practitioners. Each subject completed a questionnaire, underwent a comprehensive clinical examination and had a blood sample taken for the analysis of plasma fibrinogen, tissue plasminogen activator (t-PA) and von Willebrand factor (vWF) antigens. Subjects with trunk varicose veins and those with CVI had higher levels of each haemostatic factor compared with those with no trunk varices and no CVI. Although unit increases in t-PA and vWF were initially associated with a significantly increased risk of CVI in men, and both factors with an elevated risk of trunk varices in women, multiple adjustment for age, smoking status and body mass index reduced the odds ratios to non-significance. However, this does not entirely rule out the possibility of a pathogenic role for haemostatic factors in venous disease, but rather indicates the need for further experimental and epidemiological studies.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Wolfson Unit for Prevention of Peripheral Vascular Diseases, Public Health Sciences, Edinburgh, UK. Amanda.Lee@ed.ac.uk

    , , ,

    Source

    MeSH

    Adolescent
    Adult
    Female
    Hemostasis
    Humans
    Male
    Middle Aged
    Risk
    Scotland
    Varicose Veins

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    11132657

    Citation

    Lee, A J., et al. "Haemostatic Factors and Risk of Varicose Veins and Chronic Venous Insufficiency: Edinburgh Vein Study." Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis, vol. 11, no. 8, 2000, pp. 775-81.
    Lee AJ, Lowe GD, Rumley A, et al. Haemostatic factors and risk of varicose veins and chronic venous insufficiency: Edinburgh Vein Study. Blood Coagul Fibrinolysis. 2000;11(8):775-81.
    Lee, A. J., Lowe, G. D., Rumley, A., Ruckley, C. V., & Fowkes, F. G. (2000). Haemostatic factors and risk of varicose veins and chronic venous insufficiency: Edinburgh Vein Study. Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis, 11(8), pp. 775-81.
    Lee AJ, et al. Haemostatic Factors and Risk of Varicose Veins and Chronic Venous Insufficiency: Edinburgh Vein Study. Blood Coagul Fibrinolysis. 2000;11(8):775-81. PubMed PMID: 11132657.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Haemostatic factors and risk of varicose veins and chronic venous insufficiency: Edinburgh Vein Study. AU - Lee,A J, AU - Lowe,G D, AU - Rumley,A, AU - Ruckley,C V, AU - Fowkes,F G, PY - 2001/1/2/pubmed PY - 2001/4/6/medline PY - 2001/1/2/entrez SP - 775 EP - 81 JF - Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis JO - Blood Coagul. Fibrinolysis VL - 11 IS - 8 N2 - Despite much research, the aetiology of venous disease is still poorly understood. Since haemostatic factors are involved in the processes of fibrinolysis and platelet aggregation, it is conceivable that such processes may be implicated in the pathology of varicose veins and chronic venous insufficiency (CVI). The Edinburgh Vein Study examined 1566 men and women aged 18-64 years that were randomly selected from the lists of 12 general practitioners. Each subject completed a questionnaire, underwent a comprehensive clinical examination and had a blood sample taken for the analysis of plasma fibrinogen, tissue plasminogen activator (t-PA) and von Willebrand factor (vWF) antigens. Subjects with trunk varicose veins and those with CVI had higher levels of each haemostatic factor compared with those with no trunk varices and no CVI. Although unit increases in t-PA and vWF were initially associated with a significantly increased risk of CVI in men, and both factors with an elevated risk of trunk varices in women, multiple adjustment for age, smoking status and body mass index reduced the odds ratios to non-significance. However, this does not entirely rule out the possibility of a pathogenic role for haemostatic factors in venous disease, but rather indicates the need for further experimental and epidemiological studies. SN - 0957-5235 UR - https://www.unboundmedicine.com/medline/citation/11132657/Haemostatic_factors_and_risk_of_varicose_veins_and_chronic_venous_insufficiency:_Edinburgh_Vein_Study_ L2 - http://Insights.ovid.com/pubmed?pmid=11132657 DB - PRIME DP - Unbound Medicine ER -