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Dietary long-chain fatty acids and visual response in malnourished nursing infants.
Prostaglandins Leukot Essent Fatty Acids. 2000 Dec; 63(6):385-90.PL

Abstract

Polyunsaturated fatty acids (PUFAs) derived from essential fatty acids (EFAs) play an important role in prenatal visual and neural development. Protein-energy malnutrition affects PUFA supply, and hence the synthesis of structural lipids during growth. Recently, some physiological studies reported abnormalities in the visual function of formula-fed infants relative to breast-fed infants. The purpose of our study was to assess whether fatty acid composition of the malnourished infant diet modifies the visual function and erythrocyte phospholipid fatty acid composition. Three groups of full-term malnourished infants were selected. Two groups received commercial formulas. One of them supplied linoleic and alpha -linolenic acid: Formula I (FI), and the other supplied, in addition, long-chain PUFAs from n-3 and n-6 series: Formula II (FII). A reference group of breast-fed infants was also enrolled. Visual function was assessed using full-field flash electroretinography, and the erythrocyte phospholipid fatty acid composition was determined by gas-liquid chromatography. Those infants receiving the supplemented formula (FII) exhibited a similar retinal function to that of breast-fed infants. However, normal results were not achieved when infants were fed on the FI formula. In all groups, the results were correlated with the proportion of docosahexaenoic acid in erythrocyte phospholipid fatty acid composition. We conclude that in malnourished infants a nutrient formula enriched with long-chain fatty acids of n-6 and n-3 series could be helpful to achieve an erythrocyte fatty acid pattern and a visual function similar to that obtained in breast-fed infants.

Authors+Show Affiliations

Carrera del Investigador (CONICET), Facultad de Ciencias Médicas, Instituto de Investigaciones Bioquímicas de La Plata, CONICET-UNLP, Calle 60 y 120, La Plata, 1900, Argentina. mmarin@atlas.med.unlp.edu.arNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11133176

Citation

Marín, M C., et al. "Dietary Long-chain Fatty Acids and Visual Response in Malnourished Nursing Infants." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 63, no. 6, 2000, pp. 385-90.
Marín MC, Rey GE, Pedersolí LC, et al. Dietary long-chain fatty acids and visual response in malnourished nursing infants. Prostaglandins Leukot Essent Fatty Acids. 2000;63(6):385-90.
Marín, M. C., Rey, G. E., Pedersolí, L. C., Rodrigo, M. A., & de Alaniz, M. J. (2000). Dietary long-chain fatty acids and visual response in malnourished nursing infants. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 63(6), 385-90.
Marín MC, et al. Dietary Long-chain Fatty Acids and Visual Response in Malnourished Nursing Infants. Prostaglandins Leukot Essent Fatty Acids. 2000;63(6):385-90. PubMed PMID: 11133176.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary long-chain fatty acids and visual response in malnourished nursing infants. AU - Marín,M C, AU - Rey,G E, AU - Pedersolí,L C, AU - Rodrigo,M A, AU - de Alaniz,M J, PY - 2001/1/3/pubmed PY - 2001/3/10/medline PY - 2001/1/3/entrez SP - 385 EP - 90 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot Essent Fatty Acids VL - 63 IS - 6 N2 - Polyunsaturated fatty acids (PUFAs) derived from essential fatty acids (EFAs) play an important role in prenatal visual and neural development. Protein-energy malnutrition affects PUFA supply, and hence the synthesis of structural lipids during growth. Recently, some physiological studies reported abnormalities in the visual function of formula-fed infants relative to breast-fed infants. The purpose of our study was to assess whether fatty acid composition of the malnourished infant diet modifies the visual function and erythrocyte phospholipid fatty acid composition. Three groups of full-term malnourished infants were selected. Two groups received commercial formulas. One of them supplied linoleic and alpha -linolenic acid: Formula I (FI), and the other supplied, in addition, long-chain PUFAs from n-3 and n-6 series: Formula II (FII). A reference group of breast-fed infants was also enrolled. Visual function was assessed using full-field flash electroretinography, and the erythrocyte phospholipid fatty acid composition was determined by gas-liquid chromatography. Those infants receiving the supplemented formula (FII) exhibited a similar retinal function to that of breast-fed infants. However, normal results were not achieved when infants were fed on the FI formula. In all groups, the results were correlated with the proportion of docosahexaenoic acid in erythrocyte phospholipid fatty acid composition. We conclude that in malnourished infants a nutrient formula enriched with long-chain fatty acids of n-6 and n-3 series could be helpful to achieve an erythrocyte fatty acid pattern and a visual function similar to that obtained in breast-fed infants. SN - 0952-3278 UR - https://www.unboundmedicine.com/medline/citation/11133176/Dietary_long_chain_fatty_acids_and_visual_response_in_malnourished_nursing_infants_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952327800902291 DB - PRIME DP - Unbound Medicine ER -