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Cortical acetylcholine release elicited by stimulation of histamine H1 receptors in the nucleus basalis magnocellularis: a dual-probe microdialysis study in the freely moving rat.
Eur J Neurosci. 2001 Jan; 13(1):68-78.EJ

Abstract

Perfusion of the nucleus basalis magnocellularis (NBM) with histamine agonists and antagonists modulates the spontaneous release of cortical acetylcholine (ACh) in freely moving rats. Perfusion of the NBM with Ringer solution containing 100 mM K+ strongly stimulated the spontaneous release of cortical ACh in freely moving rats, whereas perfusion with 1 microM tetrodotoxin reduced cortical ACh spontaneous release by more than 50%. Administration of histamine to the NBM concentration-dependently increased the spontaneous release of cortical ACh. Administration of H1 (methylhistaprodifen) but not H2 (dimaprit) or H3 (R-alpha-methylhistamine) receptor agonists to the NBM mimicked the effect of histamine. Perfusion of the NBM with either H1 (mepyramine or triprolidine) or H2 (cimetidine) receptor antagonists failed to alter ACh spontaneous release from the cortex, however, H1 but not H2 receptor antagonists antagonized the releases of cortical ACh elicited by histamine and methylhistaprodifen. Local administration of H3 receptor antagonists (clobenpropit and thioperamide) to the NBM increased the spontaneous release of ACh from the cortex; this effect was antagonized by H1 receptor antagonism. Conversely local administration of MK-801, a noncompetitive receptor antagonist of the N-methyl-D-aspartate receptor, to the NBM failed to alter ACh spontaneous release from the cortex and to antagonize ACh release elicited by histamine. This study demonstrates that activation of histamine H1 receptors in the NBM increases ACh spontaneous release from the cortex.

Authors+Show Affiliations

Dipartimento di Farmacologia Preclinica e Clinica, Universitá di Firenze, V.le G. Pieraccini 6, 50139 Firenze, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11135005

Citation

Cecchi, M, et al. "Cortical Acetylcholine Release Elicited By Stimulation of Histamine H1 Receptors in the Nucleus Basalis Magnocellularis: a Dual-probe Microdialysis Study in the Freely Moving Rat." The European Journal of Neuroscience, vol. 13, no. 1, 2001, pp. 68-78.
Cecchi M, Passani MB, Bacciottini L, et al. Cortical acetylcholine release elicited by stimulation of histamine H1 receptors in the nucleus basalis magnocellularis: a dual-probe microdialysis study in the freely moving rat. Eur J Neurosci. 2001;13(1):68-78.
Cecchi, M., Passani, M. B., Bacciottini, L., Mannaioni, P. F., & Blandina, P. (2001). Cortical acetylcholine release elicited by stimulation of histamine H1 receptors in the nucleus basalis magnocellularis: a dual-probe microdialysis study in the freely moving rat. The European Journal of Neuroscience, 13(1), 68-78.
Cecchi M, et al. Cortical Acetylcholine Release Elicited By Stimulation of Histamine H1 Receptors in the Nucleus Basalis Magnocellularis: a Dual-probe Microdialysis Study in the Freely Moving Rat. Eur J Neurosci. 2001;13(1):68-78. PubMed PMID: 11135005.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cortical acetylcholine release elicited by stimulation of histamine H1 receptors in the nucleus basalis magnocellularis: a dual-probe microdialysis study in the freely moving rat. AU - Cecchi,M, AU - Passani,M B, AU - Bacciottini,L, AU - Mannaioni,P F, AU - Blandina,P, PY - 2001/1/3/pubmed PY - 2001/3/7/medline PY - 2001/1/3/entrez SP - 68 EP - 78 JF - The European journal of neuroscience JO - Eur J Neurosci VL - 13 IS - 1 N2 - Perfusion of the nucleus basalis magnocellularis (NBM) with histamine agonists and antagonists modulates the spontaneous release of cortical acetylcholine (ACh) in freely moving rats. Perfusion of the NBM with Ringer solution containing 100 mM K+ strongly stimulated the spontaneous release of cortical ACh in freely moving rats, whereas perfusion with 1 microM tetrodotoxin reduced cortical ACh spontaneous release by more than 50%. Administration of histamine to the NBM concentration-dependently increased the spontaneous release of cortical ACh. Administration of H1 (methylhistaprodifen) but not H2 (dimaprit) or H3 (R-alpha-methylhistamine) receptor agonists to the NBM mimicked the effect of histamine. Perfusion of the NBM with either H1 (mepyramine or triprolidine) or H2 (cimetidine) receptor antagonists failed to alter ACh spontaneous release from the cortex, however, H1 but not H2 receptor antagonists antagonized the releases of cortical ACh elicited by histamine and methylhistaprodifen. Local administration of H3 receptor antagonists (clobenpropit and thioperamide) to the NBM increased the spontaneous release of ACh from the cortex; this effect was antagonized by H1 receptor antagonism. Conversely local administration of MK-801, a noncompetitive receptor antagonist of the N-methyl-D-aspartate receptor, to the NBM failed to alter ACh spontaneous release from the cortex and to antagonize ACh release elicited by histamine. This study demonstrates that activation of histamine H1 receptors in the NBM increases ACh spontaneous release from the cortex. SN - 0953-816X UR - https://www.unboundmedicine.com/medline/citation/11135005/Cortical_acetylcholine_release_elicited_by_stimulation_of_histamine_H1_receptors_in_the_nucleus_basalis_magnocellularis:_a_dual_probe_microdialysis_study_in_the_freely_moving_rat_ DB - PRIME DP - Unbound Medicine ER -