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Alcohol, wine, and health.

Abstract

BACKGROUND

For the past 20 years numerous epidemiological studies have correlated the consumption of alcohol and a variety of disease states: overall mortality, arteriosclerotic vascular diseases, hypertension, cancers, peptic ulcer, respiratory infections, gall stones, kidney stones, age-related macular degeneration, bone density, and cognitive function.

METHODS

A review of these articles reveals that each of these studies has compared the outcome of individuals at various levels of alcohol consumption with that of abstainers.

RESULTS

Each analysis has identified a U-shaped or J-shaped curve of reduced relative risk for a given disease state compared with abstainers. A clear definition of consumption in moderation becomes evident: for men it should not exceed 2 to 4 drinks per day, and for women it should not exceed 1 to 2 drinks per day.

CONCLUSIONS

Alcohol by itself has favorable effects on the level of high-density lipoprotein cholesterol, and inhibition of platelet aggregation. Wine, particularly red wine, has high levels of phenolic compounds that favorably influence multiple biochemical systems, such as increased high-density lipoprotein cholesterol, antioxidant activity, decreased platelet aggregation and endothelial adhesion, suppression of cancer cell growth, and promotion of nitric oxide production.

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  • Publisher Full Text
  • Authors+Show Affiliations

    Department of Surgery, University of California at San Francisco, San Francisco, California, USA.

    Source

    American journal of surgery 180:5 2000 Nov pg 357-61

    MeSH

    Adult
    Age Factors
    Aged
    Alcohol Drinking
    Bone Density
    Breast Neoplasms
    Cardiovascular Diseases
    Cholelithiasis
    Cohort Studies
    Female
    Gastrointestinal Neoplasms
    Health
    Humans
    Kidney Calculi
    Macular Degeneration
    Male
    Middle Aged
    Pregnancy
    Prospective Studies
    Respiratory Tract Infections
    Risk Factors
    Sex Factors
    Smoking
    Stroke
    Wine

    Pub Type(s)

    Comparative Study
    Journal Article
    Review

    Language

    eng

    PubMed ID

    11137687

    Citation

    de Lorimier, A A.. "Alcohol, Wine, and Health." American Journal of Surgery, vol. 180, no. 5, 2000, pp. 357-61.
    de Lorimier AA. Alcohol, wine, and health. Am J Surg. 2000;180(5):357-61.
    de Lorimier, A. A. (2000). Alcohol, wine, and health. American Journal of Surgery, 180(5), pp. 357-61.
    de Lorimier AA. Alcohol, Wine, and Health. Am J Surg. 2000;180(5):357-61. PubMed PMID: 11137687.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Alcohol, wine, and health. A1 - de Lorimier,A A, PY - 2001/1/4/pubmed PY - 2001/2/28/medline PY - 2001/1/4/entrez SP - 357 EP - 61 JF - American journal of surgery JO - Am. J. Surg. VL - 180 IS - 5 N2 - BACKGROUND: For the past 20 years numerous epidemiological studies have correlated the consumption of alcohol and a variety of disease states: overall mortality, arteriosclerotic vascular diseases, hypertension, cancers, peptic ulcer, respiratory infections, gall stones, kidney stones, age-related macular degeneration, bone density, and cognitive function. METHODS: A review of these articles reveals that each of these studies has compared the outcome of individuals at various levels of alcohol consumption with that of abstainers. RESULTS: Each analysis has identified a U-shaped or J-shaped curve of reduced relative risk for a given disease state compared with abstainers. A clear definition of consumption in moderation becomes evident: for men it should not exceed 2 to 4 drinks per day, and for women it should not exceed 1 to 2 drinks per day. CONCLUSIONS: Alcohol by itself has favorable effects on the level of high-density lipoprotein cholesterol, and inhibition of platelet aggregation. Wine, particularly red wine, has high levels of phenolic compounds that favorably influence multiple biochemical systems, such as increased high-density lipoprotein cholesterol, antioxidant activity, decreased platelet aggregation and endothelial adhesion, suppression of cancer cell growth, and promotion of nitric oxide production. SN - 0002-9610 UR - https://www.unboundmedicine.com/medline/citation/11137687/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9610(00)00486-4 DB - PRIME DP - Unbound Medicine ER -