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The associations of maternal caffeine consumption and nausea with spontaneous abortion.
Epidemiology 2001; 12(1):38-42E

Abstract

To examine whether maternal caffeine consumption is associated with the risk of spontaneous abortion, we analyzed data from a population-based prospective study. The study population comprised 575 women delivering singleton livebirths and 75 women who had spontaneous abortions. The subjects were predominantly white, middle-class women enrolled before pregnancy. Study participants were traced to delivery of a liveborn, singleton infant or a spontaneous abortion. Of the 71 women who did not experience nausea, 29.6% had a spontaneous abortion, compared with 7.2% of 514 women who did experience nausea. Maternal caffeine consumption before pregnancy, or in women without nausea, did not increase the risk of spontaneous abortion, whereas maternal caffeine consumption during the first trimester after nausea started might increase risk of spontaneous abortion (risk ratio = 5.4, 95% confidence interval = 2.0-14.6 for caffeine consumption > or = 300 mg per day compared with < 20 mg per day). These results suggest that maternal caffeine consumption during pregnancy may influence fetal viability in women with nausea.

Authors+Show Affiliations

Department of Medicine, School of Medicine, Vanderbilt University, Nashville, TN 37232-8300, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11138817

Citation

Wen, W, et al. "The Associations of Maternal Caffeine Consumption and Nausea With Spontaneous Abortion." Epidemiology (Cambridge, Mass.), vol. 12, no. 1, 2001, pp. 38-42.
Wen W, Shu XO, Jacobs DR, et al. The associations of maternal caffeine consumption and nausea with spontaneous abortion. Epidemiology. 2001;12(1):38-42.
Wen, W., Shu, X. O., Jacobs, D. R., & Brown, J. E. (2001). The associations of maternal caffeine consumption and nausea with spontaneous abortion. Epidemiology (Cambridge, Mass.), 12(1), pp. 38-42.
Wen W, et al. The Associations of Maternal Caffeine Consumption and Nausea With Spontaneous Abortion. Epidemiology. 2001;12(1):38-42. PubMed PMID: 11138817.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The associations of maternal caffeine consumption and nausea with spontaneous abortion. AU - Wen,W, AU - Shu,X O, AU - Jacobs,D R,Jr AU - Brown,J E, PY - 2001/1/4/pubmed PY - 2001/3/3/medline PY - 2001/1/4/entrez SP - 38 EP - 42 JF - Epidemiology (Cambridge, Mass.) JO - Epidemiology VL - 12 IS - 1 N2 - To examine whether maternal caffeine consumption is associated with the risk of spontaneous abortion, we analyzed data from a population-based prospective study. The study population comprised 575 women delivering singleton livebirths and 75 women who had spontaneous abortions. The subjects were predominantly white, middle-class women enrolled before pregnancy. Study participants were traced to delivery of a liveborn, singleton infant or a spontaneous abortion. Of the 71 women who did not experience nausea, 29.6% had a spontaneous abortion, compared with 7.2% of 514 women who did experience nausea. Maternal caffeine consumption before pregnancy, or in women without nausea, did not increase the risk of spontaneous abortion, whereas maternal caffeine consumption during the first trimester after nausea started might increase risk of spontaneous abortion (risk ratio = 5.4, 95% confidence interval = 2.0-14.6 for caffeine consumption > or = 300 mg per day compared with < 20 mg per day). These results suggest that maternal caffeine consumption during pregnancy may influence fetal viability in women with nausea. SN - 1044-3983 UR - https://www.unboundmedicine.com/medline/citation/11138817/The_associations_of_maternal_caffeine_consumption_and_nausea_with_spontaneous_abortion_ L2 - http://Insights.ovid.com/pubmed?pmid=11138817 DB - PRIME DP - Unbound Medicine ER -