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A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease.
Nature. 2000 Dec 21-28; 408(6815):982-5.Nat

Abstract

Vaccinations with amyloid-beta peptide (A beta) can dramatically reduce amyloid deposition in a transgenic mouse model of Alzheimer's disease. To determine if the vaccinations had deleterious or beneficial functional consequences, we tested eight months of A beta vaccination in a different transgenic model for Alzheimer's disease in which mice develop learning deficits as amyloid accumulates. Here we show that vaccination with A beta protects transgenic mice from the learning and age-related memory deficits that normally occur in this mouse model for Alzheimer's disease. During testing for potential deleterious effects of the vaccine, all mice performed superbly on the radial-arm water-maze test of working memory. Later, at an age when untreated transgenic mice show memory deficits, the A beta-vaccinated transgenic mice showed cognitive performance superior to that of the control transgenic mice and, ultimately, performed as well as nontransgenic mice. The A beta-vaccinated mice also had a partial reduction in amyloid burden at the end of the study. This therapeutic approach may thus prevent and, possibly, treat Alzheimer's dementia.

Authors+Show Affiliations

Department of Pharmacology, University of South Florida, Tampa 33612, USA. dmorgan@hsc.usf.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11140686

Citation

Morgan, D, et al. "A Beta Peptide Vaccination Prevents Memory Loss in an Animal Model of Alzheimer's Disease." Nature, vol. 408, no. 6815, 2000, pp. 982-5.
Morgan D, Diamond DM, Gottschall PE, et al. A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature. 2000;408(6815):982-5.
Morgan, D., Diamond, D. M., Gottschall, P. E., Ugen, K. E., Dickey, C., Hardy, J., Duff, K., Jantzen, P., DiCarlo, G., Wilcock, D., Connor, K., Hatcher, J., Hope, C., Gordon, M., & Arendash, G. W. (2000). A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature, 408(6815), 982-5.
Morgan D, et al. A Beta Peptide Vaccination Prevents Memory Loss in an Animal Model of Alzheimer's Disease. Nature. 2000 Dec 21-28;408(6815):982-5. PubMed PMID: 11140686.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. AU - Morgan,D, AU - Diamond,D M, AU - Gottschall,P E, AU - Ugen,K E, AU - Dickey,C, AU - Hardy,J, AU - Duff,K, AU - Jantzen,P, AU - DiCarlo,G, AU - Wilcock,D, AU - Connor,K, AU - Hatcher,J, AU - Hope,C, AU - Gordon,M, AU - Arendash,G W, PY - 2001/1/5/pubmed PY - 2001/2/28/medline PY - 2001/1/5/entrez SP - 982 EP - 5 JF - Nature JO - Nature VL - 408 IS - 6815 N2 - Vaccinations with amyloid-beta peptide (A beta) can dramatically reduce amyloid deposition in a transgenic mouse model of Alzheimer's disease. To determine if the vaccinations had deleterious or beneficial functional consequences, we tested eight months of A beta vaccination in a different transgenic model for Alzheimer's disease in which mice develop learning deficits as amyloid accumulates. Here we show that vaccination with A beta protects transgenic mice from the learning and age-related memory deficits that normally occur in this mouse model for Alzheimer's disease. During testing for potential deleterious effects of the vaccine, all mice performed superbly on the radial-arm water-maze test of working memory. Later, at an age when untreated transgenic mice show memory deficits, the A beta-vaccinated transgenic mice showed cognitive performance superior to that of the control transgenic mice and, ultimately, performed as well as nontransgenic mice. The A beta-vaccinated mice also had a partial reduction in amyloid burden at the end of the study. This therapeutic approach may thus prevent and, possibly, treat Alzheimer's dementia. SN - 0028-0836 UR - https://www.unboundmedicine.com/medline/citation/11140686/A_beta_peptide_vaccination_prevents_memory_loss_in_an_animal_model_of_Alzheimer's_disease_ L2 - https://doi.org/10.1038/35050116 DB - PRIME DP - Unbound Medicine ER -