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Relationship between intestinal metaplasia of the gastro-oesophageal junction, Helicobacter pylori infection and gastro-oesophageal reflux disease: a prospective study.
Dig Liver Dis 2000; 32(7):567-72DL

Abstract

BACKGROUND

The role of Helicobacter pylori infection and/or gastro-oesophageal reflux disease in pathogenesis of intestinal metaplasia in gastric cardia is still unclear.

AIMS

To prospectively evaluate prevalence of inflammation and intestinal metaplasia of cardia in relationship to Helicobacter pylori infection in patients with gastro-oesophageal reflux disease and in healthy controls.

PATIENTS

A total of 122 consecutive patients with gastro-oesophageal reflux disease and 49 control subjects were included.

METHODS

During endoscopy, a total of six biopsies were taken from antrum, corpus and cardia. Helicobacter pylori infection was assessed by histology and rapid urease test. Degree of chronic gastritis, inflammatory activity and Helicobacter pylori colonization were scored from 0 to 3.

RESULTS

No difference in prevalence was observed between gastro-oesophageal reflux disease patients and controls as far as concerns Helicobacter pylori (41% vs 38%), inflammation of cardia (59.5% vs 70%) and intestinal metaplasia of cardia (18% vs 19%). Inflammation of cardia was significantly (p<0.001) associated with Helicobacter pylori irrespective of gastro-oesophageal reflux disease symptoms. Cardial intestinal metaplasia was more frequently (p=0.03) found in infected subjects ((27%) than in uncolonized subjects (13%). No relationship was observed between gastro-oesophageal reflux disease and carditis and cardial intestinal metaplasia. Cardial intestinal metaplasia was more frequently detected in association with carditis (26% vs 6%, p=0.001).

CONCLUSIONS

Inflammation and intestinal metaplasia of the gastric cardia are not markers of gastro-oesophageal reflux disease but are related to Helicobacter pylori.

Authors+Show Affiliations

Division of Internal Medicine, General Hospital F. Tappeiner, Merano, Italy. pieramico.o@rolmail.netNo affiliation info available

Pub Type(s)

Comment
Journal Article

Language

eng

PubMed ID

11142553

Citation

Pieramico, O, and M V. Zanetti. "Relationship Between Intestinal Metaplasia of the Gastro-oesophageal Junction, Helicobacter Pylori Infection and Gastro-oesophageal Reflux Disease: a Prospective Study." Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, vol. 32, no. 7, 2000, pp. 567-72.
Pieramico O, Zanetti MV. Relationship between intestinal metaplasia of the gastro-oesophageal junction, Helicobacter pylori infection and gastro-oesophageal reflux disease: a prospective study. Dig Liver Dis. 2000;32(7):567-72.
Pieramico, O., & Zanetti, M. V. (2000). Relationship between intestinal metaplasia of the gastro-oesophageal junction, Helicobacter pylori infection and gastro-oesophageal reflux disease: a prospective study. Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 32(7), pp. 567-72.
Pieramico O, Zanetti MV. Relationship Between Intestinal Metaplasia of the Gastro-oesophageal Junction, Helicobacter Pylori Infection and Gastro-oesophageal Reflux Disease: a Prospective Study. Dig Liver Dis. 2000;32(7):567-72. PubMed PMID: 11142553.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between intestinal metaplasia of the gastro-oesophageal junction, Helicobacter pylori infection and gastro-oesophageal reflux disease: a prospective study. AU - Pieramico,O, AU - Zanetti,M V, PY - 2001/1/6/pubmed PY - 2001/3/7/medline PY - 2001/1/6/entrez SP - 567 EP - 72 JF - Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver JO - Dig Liver Dis VL - 32 IS - 7 N2 - BACKGROUND: The role of Helicobacter pylori infection and/or gastro-oesophageal reflux disease in pathogenesis of intestinal metaplasia in gastric cardia is still unclear. AIMS: To prospectively evaluate prevalence of inflammation and intestinal metaplasia of cardia in relationship to Helicobacter pylori infection in patients with gastro-oesophageal reflux disease and in healthy controls. PATIENTS: A total of 122 consecutive patients with gastro-oesophageal reflux disease and 49 control subjects were included. METHODS: During endoscopy, a total of six biopsies were taken from antrum, corpus and cardia. Helicobacter pylori infection was assessed by histology and rapid urease test. Degree of chronic gastritis, inflammatory activity and Helicobacter pylori colonization were scored from 0 to 3. RESULTS: No difference in prevalence was observed between gastro-oesophageal reflux disease patients and controls as far as concerns Helicobacter pylori (41% vs 38%), inflammation of cardia (59.5% vs 70%) and intestinal metaplasia of cardia (18% vs 19%). Inflammation of cardia was significantly (p<0.001) associated with Helicobacter pylori irrespective of gastro-oesophageal reflux disease symptoms. Cardial intestinal metaplasia was more frequently (p=0.03) found in infected subjects ((27%) than in uncolonized subjects (13%). No relationship was observed between gastro-oesophageal reflux disease and carditis and cardial intestinal metaplasia. Cardial intestinal metaplasia was more frequently detected in association with carditis (26% vs 6%, p=0.001). CONCLUSIONS: Inflammation and intestinal metaplasia of the gastric cardia are not markers of gastro-oesophageal reflux disease but are related to Helicobacter pylori. SN - 1590-8658 UR - https://www.unboundmedicine.com/medline/citation/11142553/Relationship_between_intestinal_metaplasia_of_the_gastro_oesophageal_junction_Helicobacter_pylori_infection_and_gastro_oesophageal_reflux_disease:_a_prospective_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1590-8658(00)80837-3 DB - PRIME DP - Unbound Medicine ER -