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Relationship between antral lymphocyte density and basal gastrin levels in patients with Helicobacter pylori infection.
Dig Liver Dis. 2000 Nov; 32(8):676-81.DL

Abstract

BACKGROUND

The mechanism by which Helicobacter pylori causes hypergastrinaemia is not completely understood.

AIM

To evaluate whether antral lymphocyte density could play a role in this alteration.

METHODS

A total of 12 patients with active duodenal ulcer and 10 with non-ulcer dyspepsia were enrolled upon detection of Helicobacter pylori infection at endoscopy Enrolled as controls were 7 matched dyspeptic patients without Helicobacter pylori infection. Biopsy specimens were collected for Helicobacter pylori and histological assessments, and for antral lymphocyte density assessment by a histomorphometric method. A blood sample was obtained from each patient to determine basal gastrin levels. All patients were controlled by a further endoscopy 4 weeks after the end of Helicobacter pylori treatment.

RESULTS

Antral lymphocyte density (5,464 +/- 1,328 and 5,635 +/- 1,186 vs 2,267 +/- 557 lymphocytes/mm2; p<0.001 and p<0.001, respectively) and gastrin levels (66.7 +/- 14.1 and 60.4 +/- 21.7 vs 40.7 +/- 7.8 pg/dl; p=0.004 and p=0.02, respectively) were higher in duodenal ulcer and non-ulcer dyspepsia patients than in controls, while no significant differences emerged between duodenal ulcer and non-ulcer dyspepsia patients. There was a significant direct correlation between antral lymphocyte density and gastrin levels both in duodenal ulcer (r=0.77; p=0.003) and in non-ulcer dyspepsia (r=0.75; p=0.03) patients, while no correlation was found in controls [r=0.12; p=0.8). After treatment, this correlation persisted in 10 eradication failure patients (r=0.68; p=0.027), but disappeared in those successfully cured.

CONCLUSIONS

These data suggest that lymphocyte density in the antral mucosa could play a role in the impaired gastrin production occurring in patients with Helicobacter pylori infection.

Authors+Show Affiliations

De Francesco V
Department of Clinical Medicine, Gastroenterology II, La Sapienza University, Rome, Italy.
Zullo A
No affiliation info available
Rinaldi V
No affiliation info available
Hassan C
No affiliation info available
Ballanti P
No affiliation info available
Winn S
No affiliation info available
Diana F
No affiliation info available
Morini S
No affiliation info available
Attili AF
No affiliation info available

MeSH

AdultAgedBiopsyDuodenal UlcerDyspepsiaFemaleGastric MucosaGastrinsHelicobacter InfectionsHelicobacter pyloriHumansLymphocytesMaleMiddle AgedPyloric Antrum

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11142576

Citation

De Francesco, V, et al. "Relationship Between Antral Lymphocyte Density and Basal Gastrin Levels in Patients With Helicobacter Pylori Infection." Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, vol. 32, no. 8, 2000, pp. 676-81.
De Francesco V, Zullo A, Rinaldi V, et al. Relationship between antral lymphocyte density and basal gastrin levels in patients with Helicobacter pylori infection. Dig Liver Dis. 2000;32(8):676-81.
De Francesco, V., Zullo, A., Rinaldi, V., Hassan, C., Ballanti, P., Winn, S., Diana, F., Morini, S., & Attili, A. F. (2000). Relationship between antral lymphocyte density and basal gastrin levels in patients with Helicobacter pylori infection. Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 32(8), 676-81.
De Francesco V, et al. Relationship Between Antral Lymphocyte Density and Basal Gastrin Levels in Patients With Helicobacter Pylori Infection. Dig Liver Dis. 2000;32(8):676-81. PubMed PMID: 11142576.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between antral lymphocyte density and basal gastrin levels in patients with Helicobacter pylori infection. AU - De Francesco,V, AU - Zullo,A, AU - Rinaldi,V, AU - Hassan,C, AU - Ballanti,P, AU - Winn,S, AU - Diana,F, AU - Morini,S, AU - Attili,A F, PY - 2001/1/6/pubmed PY - 2001/3/7/medline PY - 2001/1/6/entrez SP - 676 EP - 81 JF - Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver JO - Dig Liver Dis VL - 32 IS - 8 N2 - BACKGROUND: The mechanism by which Helicobacter pylori causes hypergastrinaemia is not completely understood. AIM: To evaluate whether antral lymphocyte density could play a role in this alteration. METHODS: A total of 12 patients with active duodenal ulcer and 10 with non-ulcer dyspepsia were enrolled upon detection of Helicobacter pylori infection at endoscopy Enrolled as controls were 7 matched dyspeptic patients without Helicobacter pylori infection. Biopsy specimens were collected for Helicobacter pylori and histological assessments, and for antral lymphocyte density assessment by a histomorphometric method. A blood sample was obtained from each patient to determine basal gastrin levels. All patients were controlled by a further endoscopy 4 weeks after the end of Helicobacter pylori treatment. RESULTS: Antral lymphocyte density (5,464 +/- 1,328 and 5,635 +/- 1,186 vs 2,267 +/- 557 lymphocytes/mm2; p<0.001 and p<0.001, respectively) and gastrin levels (66.7 +/- 14.1 and 60.4 +/- 21.7 vs 40.7 +/- 7.8 pg/dl; p=0.004 and p=0.02, respectively) were higher in duodenal ulcer and non-ulcer dyspepsia patients than in controls, while no significant differences emerged between duodenal ulcer and non-ulcer dyspepsia patients. There was a significant direct correlation between antral lymphocyte density and gastrin levels both in duodenal ulcer (r=0.77; p=0.003) and in non-ulcer dyspepsia (r=0.75; p=0.03) patients, while no correlation was found in controls [r=0.12; p=0.8). After treatment, this correlation persisted in 10 eradication failure patients (r=0.68; p=0.027), but disappeared in those successfully cured. CONCLUSIONS: These data suggest that lymphocyte density in the antral mucosa could play a role in the impaired gastrin production occurring in patients with Helicobacter pylori infection. SN - 1590-8658 UR - https://www.unboundmedicine.com/medline/citation/11142576/Relationship_between_antral_lymphocyte_density_and_basal_gastrin_levels_in_patients_with_Helicobacter_pylori_infection_ DB - PRIME DP - Unbound Medicine ER -