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Correlation of apolipoprotein E gene polymorphism to serum lipid concentrations in healthy Thais.
J Med Assoc Thai. 2000 Oct; 83(10):1233-9.JM

Abstract

This study determined the genotype distribution of apolipoprotein E (apo E) gene and its relation to serum lipids in 217 healthy Thais consisting of 79 males and 138 females. Serum total cholesterol (TC), HDL-cholesterol (HDL-C) and triglyceride (TG) concentrations were determined by enzymatic-colorimetric methods, while serum LDL-cholesterol (LDL-C) levels were calculated using Friedewald formula. Apo E genotypes were determined by PCR-RFLP. Out of 217 subjects, apo E genotype frequencies were 5.5 per cent for E2/E2, 12.4 per cent for E2/E3, 81.1 per cent for E3/E3 and 0.9 per cent for E4/E4. In men, advancing age was associated with increased serum TC (r = 0.28, P < 0.05) and LDL-C (r = 0.27, P < 0.01). Subjects having the E2 allele had lower TC (r = -0.27, P < 0.05) and LDL-C. (r = -0.25, P < 0.05). Age and apo E genotypes were not associated with HDL-C and TG in men. In women, increasing age was related to higher serum TC (r = 0.45, P < 0.001), LDL-C (r = 0.44, P < 0.001), TG (r = 0.40, P < 0.001) and lower HDL-C (r = -0.36, P < 0.001). The presence of E2 allele was related to lower TC (r = -0.24, P < 0.001), LDL-C (r = -0.26, P < 0.001), TG (r = -0.15, P < 0.05) and higher HDL-C (r = 0.20, P < 0.01) independent of age and menopausal status. We concluded that the epsilon 4 allele of apo E gene is rare in Thais. The presence of the epsilon 2 allele is associated with a more favorable lipid profile and there is a sexual dimorphism concerning the effect of apo E genotype on serum HDL-C and TG.

Authors+Show Affiliations

Research Center, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11143490

Citation

Chanprasertyothin, S, et al. "Correlation of Apolipoprotein E Gene Polymorphism to Serum Lipid Concentrations in Healthy Thais." Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, vol. 83, no. 10, 2000, pp. 1233-9.
Chanprasertyothin S, Ongphiphadhanakul B, Rajatanavin R, et al. Correlation of apolipoprotein E gene polymorphism to serum lipid concentrations in healthy Thais. J Med Assoc Thai. 2000;83(10):1233-9.
Chanprasertyothin, S., Ongphiphadhanakul, B., Rajatanavin, R., Piaseu, N., Chailurkit, L. O., & Puavilai, G. (2000). Correlation of apolipoprotein E gene polymorphism to serum lipid concentrations in healthy Thais. Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, 83(10), 1233-9.
Chanprasertyothin S, et al. Correlation of Apolipoprotein E Gene Polymorphism to Serum Lipid Concentrations in Healthy Thais. J Med Assoc Thai. 2000;83(10):1233-9. PubMed PMID: 11143490.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation of apolipoprotein E gene polymorphism to serum lipid concentrations in healthy Thais. AU - Chanprasertyothin,S, AU - Ongphiphadhanakul,B, AU - Rajatanavin,R, AU - Piaseu,N, AU - Chailurkit,L O, AU - Puavilai,G, PY - 2001/1/6/pubmed PY - 2001/2/28/medline PY - 2001/1/6/entrez SP - 1233 EP - 9 JF - Journal of the Medical Association of Thailand = Chotmaihet thangphaet JO - J Med Assoc Thai VL - 83 IS - 10 N2 - This study determined the genotype distribution of apolipoprotein E (apo E) gene and its relation to serum lipids in 217 healthy Thais consisting of 79 males and 138 females. Serum total cholesterol (TC), HDL-cholesterol (HDL-C) and triglyceride (TG) concentrations were determined by enzymatic-colorimetric methods, while serum LDL-cholesterol (LDL-C) levels were calculated using Friedewald formula. Apo E genotypes were determined by PCR-RFLP. Out of 217 subjects, apo E genotype frequencies were 5.5 per cent for E2/E2, 12.4 per cent for E2/E3, 81.1 per cent for E3/E3 and 0.9 per cent for E4/E4. In men, advancing age was associated with increased serum TC (r = 0.28, P < 0.05) and LDL-C (r = 0.27, P < 0.01). Subjects having the E2 allele had lower TC (r = -0.27, P < 0.05) and LDL-C. (r = -0.25, P < 0.05). Age and apo E genotypes were not associated with HDL-C and TG in men. In women, increasing age was related to higher serum TC (r = 0.45, P < 0.001), LDL-C (r = 0.44, P < 0.001), TG (r = 0.40, P < 0.001) and lower HDL-C (r = -0.36, P < 0.001). The presence of E2 allele was related to lower TC (r = -0.24, P < 0.001), LDL-C (r = -0.26, P < 0.001), TG (r = -0.15, P < 0.05) and higher HDL-C (r = 0.20, P < 0.01) independent of age and menopausal status. We concluded that the epsilon 4 allele of apo E gene is rare in Thais. The presence of the epsilon 2 allele is associated with a more favorable lipid profile and there is a sexual dimorphism concerning the effect of apo E genotype on serum HDL-C and TG. SN - 0125-2208 UR - https://www.unboundmedicine.com/medline/citation/11143490/Correlation_of_apolipoprotein_E_gene_polymorphism_to_serum_lipid_concentrations_in_healthy_Thais_ L2 - https://medlineplus.gov/hdlthegoodcholesterol.html DB - PRIME DP - Unbound Medicine ER -