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Comparison of the palatability of the oral suspension of cefdinir vs. amoxicillin/clavulanate potassium, cefprozil and azithromycin in pediatric patients.
Pediatr Infect Dis J. 2000 Dec; 19(12 Suppl):S174-80.PI

Abstract

BACKGROUND

Patient adherence to therapeutic regimens is extremely important to successful treatment of acute otitis media. Among pediatric patients medication palatability, particularly that of oral suspensions, is essential for patient acceptance, therapeutic compliance and successful outcome.

METHODS

A series of six randomized, single blind, crossover trials were conducted, each comparing cefdinir oral suspension with one of the following antibiotic oral suspensions: amoxicillin/clavulanate potassium; cefprozil; or azithromycin. Each medication comparison was evaluated in a single center and multicenter study. Subjects 4 to 8 years of age were asked to taste and smell each medication and assign preference using a visual "smile-face" scale. Ratings were converted to a numeric score ranging from 5 ("really good") to 1 ("really bad").

RESULTS

Among the 715 subjects 85% rated the taste of cefdinir as good or really good, the highest possible ratings; 63% of subjects assigned the same ratings to amoxicillin/clavulanate potassium, cefprozil or azithromycin. Seventy-one percent rated the smell of cefdinir as good or really good; 64% assigned the same ratings to the comparators.

CONCLUSIONS

Based on the findings from these trials, children 4 to 8 years of age preferred the taste and smell of cefdinir oral suspension to that of the comparator agents.

Authors+Show Affiliations

Hill Top Research, Inc, Scottsdale, AZ, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11144401

Citation

Powers, J L., et al. "Comparison of the Palatability of the Oral Suspension of Cefdinir Vs. Amoxicillin/clavulanate Potassium, Cefprozil and Azithromycin in Pediatric Patients." The Pediatric Infectious Disease Journal, vol. 19, no. 12 Suppl, 2000, pp. S174-80.
Powers JL, Gooch WM, Oddo LP. Comparison of the palatability of the oral suspension of cefdinir vs. amoxicillin/clavulanate potassium, cefprozil and azithromycin in pediatric patients. Pediatr Infect Dis J. 2000;19(12 Suppl):S174-80.
Powers, J. L., Gooch, W. M., & Oddo, L. P. (2000). Comparison of the palatability of the oral suspension of cefdinir vs. amoxicillin/clavulanate potassium, cefprozil and azithromycin in pediatric patients. The Pediatric Infectious Disease Journal, 19(12 Suppl), S174-80.
Powers JL, Gooch WM, Oddo LP. Comparison of the Palatability of the Oral Suspension of Cefdinir Vs. Amoxicillin/clavulanate Potassium, Cefprozil and Azithromycin in Pediatric Patients. Pediatr Infect Dis J. 2000;19(12 Suppl):S174-80. PubMed PMID: 11144401.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of the palatability of the oral suspension of cefdinir vs. amoxicillin/clavulanate potassium, cefprozil and azithromycin in pediatric patients. AU - Powers,J L, AU - Gooch,W M,3rd AU - Oddo,L P, PY - 2001/1/6/pubmed PY - 2001/5/1/medline PY - 2001/1/6/entrez SP - S174 EP - 80 JF - The Pediatric infectious disease journal JO - Pediatr Infect Dis J VL - 19 IS - 12 Suppl N2 - BACKGROUND: Patient adherence to therapeutic regimens is extremely important to successful treatment of acute otitis media. Among pediatric patients medication palatability, particularly that of oral suspensions, is essential for patient acceptance, therapeutic compliance and successful outcome. METHODS: A series of six randomized, single blind, crossover trials were conducted, each comparing cefdinir oral suspension with one of the following antibiotic oral suspensions: amoxicillin/clavulanate potassium; cefprozil; or azithromycin. Each medication comparison was evaluated in a single center and multicenter study. Subjects 4 to 8 years of age were asked to taste and smell each medication and assign preference using a visual "smile-face" scale. Ratings were converted to a numeric score ranging from 5 ("really good") to 1 ("really bad"). RESULTS: Among the 715 subjects 85% rated the taste of cefdinir as good or really good, the highest possible ratings; 63% of subjects assigned the same ratings to amoxicillin/clavulanate potassium, cefprozil or azithromycin. Seventy-one percent rated the smell of cefdinir as good or really good; 64% assigned the same ratings to the comparators. CONCLUSIONS: Based on the findings from these trials, children 4 to 8 years of age preferred the taste and smell of cefdinir oral suspension to that of the comparator agents. SN - 0891-3668 UR - https://www.unboundmedicine.com/medline/citation/11144401/Comparison_of_the_palatability_of_the_oral_suspension_of_cefdinir_vs__amoxicillin/clavulanate_potassium_cefprozil_and_azithromycin_in_pediatric_patients_ L2 - https://doi.org/10.1097/00006454-200012001-00008 DB - PRIME DP - Unbound Medicine ER -