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High-monounsaturated fat, olive oil-rich diet has effects similar to a high-carbohydrate diet on fasting and postprandial state and metabolic profiles of patients with type 2 diabetes.

Abstract

Whether metabolic control in type 2 diabetes mellitus (DM) is best achieved with the traditional high-carbohydrate (CHO), low-fat diet or a low-CHO, high-fat diet is still controversial. In a randomized crossover study, we compared the effects of a low-fat (30% of daily energy) diet and a high-fat (40% of daily energy), high-monounsaturated-fat diet for 6 weeks each on fasting and postprandial glucose, insulin, and lipoprotein concentrations in 12 patients with well-controlled type 2 DM (fasting blood glucose, 176 +/- 54 mg/dL; hemoglobin A1c, 6.4% +/- 0.7%) and no overt dyslipidemia (serum total cholesterol, 235 +/- 43 mg/dL; triglycerides, 180 +/- 63 mg/dL). Home-prepared foods were used and olive oil was the main edible fat, accounting for 8% and 25% of daily energy requirements in the low-fat and high-fat diets, respectively. For postprandial studies, the same mixed meal containing 36% fat was used in both dietary periods. Body weight and fasting and 6-hour postprandial blood glucose, insulin, and lipoprotein levels were similar after the two diets. The mean incremental area under the curve of serum triglycerides 0 to 6 hours after the challenge meal, adjusted for baseline levels, did not change significantly after the high-fat diet compared with the low-fat diet (1,484 +/- 546 v 1,714 +/- 709 mg x 6 h/dL, respectively, P = .099). Mean postprandial triglyceride levels at 6 hours were increased about 2 times over fasting levels and were still greater than 300 mg/dL after either diet. A diet high in total and monounsaturated fat at the expense of olive oil is a good alternative diet to the traditional low-fat diet for patients with type 2 DM. However, ongoing postprandial hypertriglyceridemia with either diet points to the need for other therapies to decrease triglyceride-rich lipoproteins (TRL) and the inherent atherogenic risk in type 2 diabetics.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Lipid Clinic, Nutrition and Dietetics Service, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Hospital Clínic i Provincial, Barcelona, Spain.

    , , , , ,

    Source

    Metabolism: clinical and experimental 49:12 2000 Dec pg 1511-7

    MeSH

    Diabetes Mellitus, Type 2
    Diet
    Dietary Carbohydrates
    Dietary Fats, Unsaturated
    Fasting
    Humans
    Olive Oil
    Plant Oils
    Postprandial Period
    Triglycerides

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    11145109

    Citation

    Rodríguez-Villar, C, et al. "High-monounsaturated Fat, Olive Oil-rich Diet Has Effects Similar to a High-carbohydrate Diet On Fasting and Postprandial State and Metabolic Profiles of Patients With Type 2 Diabetes." Metabolism: Clinical and Experimental, vol. 49, no. 12, 2000, pp. 1511-7.
    Rodríguez-Villar C, Manzanares JM, Casals E, et al. High-monounsaturated fat, olive oil-rich diet has effects similar to a high-carbohydrate diet on fasting and postprandial state and metabolic profiles of patients with type 2 diabetes. Metab Clin Exp. 2000;49(12):1511-7.
    Rodríguez-Villar, C., Manzanares, J. M., Casals, E., Pérez-Heras, A., Zambón, D., Gomis, R., & Ros, E. (2000). High-monounsaturated fat, olive oil-rich diet has effects similar to a high-carbohydrate diet on fasting and postprandial state and metabolic profiles of patients with type 2 diabetes. Metabolism: Clinical and Experimental, 49(12), pp. 1511-7.
    Rodríguez-Villar C, et al. High-monounsaturated Fat, Olive Oil-rich Diet Has Effects Similar to a High-carbohydrate Diet On Fasting and Postprandial State and Metabolic Profiles of Patients With Type 2 Diabetes. Metab Clin Exp. 2000;49(12):1511-7. PubMed PMID: 11145109.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - High-monounsaturated fat, olive oil-rich diet has effects similar to a high-carbohydrate diet on fasting and postprandial state and metabolic profiles of patients with type 2 diabetes. AU - Rodríguez-Villar,C, AU - Manzanares,J M, AU - Casals,E, AU - Pérez-Heras,A, AU - Zambón,D, AU - Gomis,R, AU - Ros,E, PY - 2001/1/6/pubmed PY - 2001/2/28/medline PY - 2001/1/6/entrez SP - 1511 EP - 7 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 49 IS - 12 N2 - Whether metabolic control in type 2 diabetes mellitus (DM) is best achieved with the traditional high-carbohydrate (CHO), low-fat diet or a low-CHO, high-fat diet is still controversial. In a randomized crossover study, we compared the effects of a low-fat (30% of daily energy) diet and a high-fat (40% of daily energy), high-monounsaturated-fat diet for 6 weeks each on fasting and postprandial glucose, insulin, and lipoprotein concentrations in 12 patients with well-controlled type 2 DM (fasting blood glucose, 176 +/- 54 mg/dL; hemoglobin A1c, 6.4% +/- 0.7%) and no overt dyslipidemia (serum total cholesterol, 235 +/- 43 mg/dL; triglycerides, 180 +/- 63 mg/dL). Home-prepared foods were used and olive oil was the main edible fat, accounting for 8% and 25% of daily energy requirements in the low-fat and high-fat diets, respectively. For postprandial studies, the same mixed meal containing 36% fat was used in both dietary periods. Body weight and fasting and 6-hour postprandial blood glucose, insulin, and lipoprotein levels were similar after the two diets. The mean incremental area under the curve of serum triglycerides 0 to 6 hours after the challenge meal, adjusted for baseline levels, did not change significantly after the high-fat diet compared with the low-fat diet (1,484 +/- 546 v 1,714 +/- 709 mg x 6 h/dL, respectively, P = .099). Mean postprandial triglyceride levels at 6 hours were increased about 2 times over fasting levels and were still greater than 300 mg/dL after either diet. A diet high in total and monounsaturated fat at the expense of olive oil is a good alternative diet to the traditional low-fat diet for patients with type 2 DM. However, ongoing postprandial hypertriglyceridemia with either diet points to the need for other therapies to decrease triglyceride-rich lipoproteins (TRL) and the inherent atherogenic risk in type 2 diabetics. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/11145109/High_monounsaturated_fat_olive_oil_rich_diet_has_effects_similar_to_a_high_carbohydrate_diet_on_fasting_and_postprandial_state_and_metabolic_profiles_of_patients_with_type_2_diabetes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026049500497623 DB - PRIME DP - Unbound Medicine ER -