Tags

Type your tag names separated by a space and hit enter

Long-term safety and efficacy of tacrolimus ointment for the treatment of atopic dermatitis in children.
J Am Acad Dermatol. 2001 Jan; 44(1 Suppl):S58-64.JA

Abstract

Tacrolimus ointment is a nonsteroidal topical immunomodulator that was formulated specifically for the treatment of atopic dermatitis. A total of 255 children, 2 to 15 years of age, with moderate to severe atopic dermatitis applied 0.1% tacrolimus ointment twice daily for up to 12 months to assess long-term safety and efficacy. Patients on average were treated with tacrolimus ointment for 279 days or 87% of study days. Substantial improvements in the signs and symptoms of atopic dermatitis, percent body surface area affected, and the patient's or parent's assessment of pruritus were observed during the first week of treatment and were maintained throughout the study. Transient skin burning and itching were the most common drug application site adverse events. Occurrence of these symptoms decreased after the first few days of treatment. There was no increased incidence of infections or other significant adverse events. Effectiveness of tacrolimus was maintained with prolonged daily use. Tacrolimus ointment (0.1%) is safe and effective for long-term treatment of atopic dermatitis in children.

Authors+Show Affiliations

University of Michigan Medical Center, Ann Arbor 48109-0314, USA. swkang@umich.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11145796

Citation

Kang, S, et al. "Long-term Safety and Efficacy of Tacrolimus Ointment for the Treatment of Atopic Dermatitis in Children." Journal of the American Academy of Dermatology, vol. 44, no. 1 Suppl, 2001, pp. S58-64.
Kang S, Lucky AW, Pariser D, et al. Long-term safety and efficacy of tacrolimus ointment for the treatment of atopic dermatitis in children. J Am Acad Dermatol. 2001;44(1 Suppl):S58-64.
Kang, S., Lucky, A. W., Pariser, D., Lawrence, I., & Hanifin, J. M. (2001). Long-term safety and efficacy of tacrolimus ointment for the treatment of atopic dermatitis in children. Journal of the American Academy of Dermatology, 44(1 Suppl), S58-64.
Kang S, et al. Long-term Safety and Efficacy of Tacrolimus Ointment for the Treatment of Atopic Dermatitis in Children. J Am Acad Dermatol. 2001;44(1 Suppl):S58-64. PubMed PMID: 11145796.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term safety and efficacy of tacrolimus ointment for the treatment of atopic dermatitis in children. AU - Kang,S, AU - Lucky,A W, AU - Pariser,D, AU - Lawrence,I, AU - Hanifin,J M, PY - 2001/1/6/pubmed PY - 2001/3/3/medline PY - 2001/1/6/entrez SP - S58 EP - 64 JF - Journal of the American Academy of Dermatology JO - J. Am. Acad. Dermatol. VL - 44 IS - 1 Suppl N2 - Tacrolimus ointment is a nonsteroidal topical immunomodulator that was formulated specifically for the treatment of atopic dermatitis. A total of 255 children, 2 to 15 years of age, with moderate to severe atopic dermatitis applied 0.1% tacrolimus ointment twice daily for up to 12 months to assess long-term safety and efficacy. Patients on average were treated with tacrolimus ointment for 279 days or 87% of study days. Substantial improvements in the signs and symptoms of atopic dermatitis, percent body surface area affected, and the patient's or parent's assessment of pruritus were observed during the first week of treatment and were maintained throughout the study. Transient skin burning and itching were the most common drug application site adverse events. Occurrence of these symptoms decreased after the first few days of treatment. There was no increased incidence of infections or other significant adverse events. Effectiveness of tacrolimus was maintained with prolonged daily use. Tacrolimus ointment (0.1%) is safe and effective for long-term treatment of atopic dermatitis in children. SN - 0190-9622 UR - https://www.unboundmedicine.com/medline/citation/11145796/Long_term_safety_and_efficacy_of_tacrolimus_ointment_for_the_treatment_of_atopic_dermatitis_in_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0190-9622(01)13173-7 DB - PRIME DP - Unbound Medicine ER -