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Incidence of open-angle glaucoma: the Barbados Eye Studies. The Barbados Eye Studies Group.
Arch Ophthalmol 2001; 119(1):89-95AO

Abstract

OBJECTIVE

To measure the 4-year risk of open-angle glaucoma (OAG) in a black population.

DESIGN

Population-based cohort study with 4 years of follow-up.

SETTING

Simple random sample of residents of Barbados, West Indies, aged 40 years or older.

PARTICIPANTS

A total of 3427 members of the cohort (85% of those eligible).

MAIN OUTCOME MEASURE

Development of glaucoma visual field defects and optic disc damage, confirmed by automated perimetry, independent fundus photographic gradings, and standardized ophthalmologic examinations.

RESULTS

The 4-year risk of OAG in black participants was 2.2% (95% confidence interval, 1.7%-2.8%), based on 67 newly developed cases of OAG. Incidence rates increased from 1.2% at ages 40 to 49 years to 4.2% at ages of 70 years or more, tending to be higher in men than women (2.7% vs 1.9%). About half of the incident cases were undiagnosed previously, and the rest were receiving OAG treatment. Of the 67 new cases of OAG, 32 had intraocular pressure of 21 mm Hg or less at baseline (1.2% incidence) and 35 had higher pressures (9% incidence). Risk was highest among persons classified as having suspect OAG at baseline (26.1%), followed by those with ocular hypertension (4.9%) and lowest in the remaining population (0.8%).

CONCLUSIONS

This longitudinal study provides new information on OAG risk, as well as the first incidence measurement in a black population. Although intraocular pressure increased risk, about half of the new cases had baseline pressures of 21 mm Hg or less. Results substantiate the high OAG risk in the population of African origin, especially in older adults; the relative role of intraocular pressure; and the considerable underdetection of new disease after 4 years of follow-up.

Authors+Show Affiliations

Department of Preventive Medicine, State University of New York at Stony Brook, HSC L3 086, Stony Brook, NY 11794-8036. cleske@uhmc.sunysb.edu.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11146731

Citation

Leske, M C., et al. "Incidence of Open-angle Glaucoma: the Barbados Eye Studies. the Barbados Eye Studies Group." Archives of Ophthalmology (Chicago, Ill. : 1960), vol. 119, no. 1, 2001, pp. 89-95.
Leske MC, Connell AM, Wu SY, et al. Incidence of open-angle glaucoma: the Barbados Eye Studies. The Barbados Eye Studies Group. Arch Ophthalmol. 2001;119(1):89-95.
Leske, M. C., Connell, A. M., Wu, S. Y., Nemesure, B., Li, X., Schachat, A., & Hennis, A. (2001). Incidence of open-angle glaucoma: the Barbados Eye Studies. The Barbados Eye Studies Group. Archives of Ophthalmology (Chicago, Ill. : 1960), 119(1), pp. 89-95.
Leske MC, et al. Incidence of Open-angle Glaucoma: the Barbados Eye Studies. the Barbados Eye Studies Group. Arch Ophthalmol. 2001;119(1):89-95. PubMed PMID: 11146731.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Incidence of open-angle glaucoma: the Barbados Eye Studies. The Barbados Eye Studies Group. AU - Leske,M C, AU - Connell,A M, AU - Wu,S Y, AU - Nemesure,B, AU - Li,X, AU - Schachat,A, AU - Hennis,A, PY - 2001/2/7/pubmed PY - 2001/2/28/medline PY - 2001/2/7/entrez SP - 89 EP - 95 JF - Archives of ophthalmology (Chicago, Ill. : 1960) JO - Arch. Ophthalmol. VL - 119 IS - 1 N2 - OBJECTIVE: To measure the 4-year risk of open-angle glaucoma (OAG) in a black population. DESIGN: Population-based cohort study with 4 years of follow-up. SETTING: Simple random sample of residents of Barbados, West Indies, aged 40 years or older. PARTICIPANTS: A total of 3427 members of the cohort (85% of those eligible). MAIN OUTCOME MEASURE: Development of glaucoma visual field defects and optic disc damage, confirmed by automated perimetry, independent fundus photographic gradings, and standardized ophthalmologic examinations. RESULTS: The 4-year risk of OAG in black participants was 2.2% (95% confidence interval, 1.7%-2.8%), based on 67 newly developed cases of OAG. Incidence rates increased from 1.2% at ages 40 to 49 years to 4.2% at ages of 70 years or more, tending to be higher in men than women (2.7% vs 1.9%). About half of the incident cases were undiagnosed previously, and the rest were receiving OAG treatment. Of the 67 new cases of OAG, 32 had intraocular pressure of 21 mm Hg or less at baseline (1.2% incidence) and 35 had higher pressures (9% incidence). Risk was highest among persons classified as having suspect OAG at baseline (26.1%), followed by those with ocular hypertension (4.9%) and lowest in the remaining population (0.8%). CONCLUSIONS: This longitudinal study provides new information on OAG risk, as well as the first incidence measurement in a black population. Although intraocular pressure increased risk, about half of the new cases had baseline pressures of 21 mm Hg or less. Results substantiate the high OAG risk in the population of African origin, especially in older adults; the relative role of intraocular pressure; and the considerable underdetection of new disease after 4 years of follow-up. SN - 0003-9950 UR - https://www.unboundmedicine.com/medline/citation/11146731/Incidence_of_open_angle_glaucoma:_the_Barbados_Eye_Studies__The_Barbados_Eye_Studies_Group_ L2 - https://jamanetwork.com/journals/jamaophthalmology/fullarticle/vol/119/pg/89 DB - PRIME DP - Unbound Medicine ER -