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Bone minerals changes in obese women during a moderate weight loss with and without calcium supplementation.
J Bone Miner Res 2001; 16(1):141-7JB

Abstract

A significant relationship between body weight (BW) and bone mass (BM) has been established previously. A diet-induced weight loss is accompanied by a significant decrease in bone mineral density (BMD) and total body bone mineral (TBBM), but the underlying mechanisms are not clarified. Sixty-two obese women were included in the study. Dual-energy X-ray absorptiometry (DXA) and measurements of a series of calcium-regulating hormones and biochemical markers of bone turnover were performed at baseline and after 1 month and 3 months on a low calorie diet. Thirty of the women were randomized to a daily supplement of 1 g of calcium. After an additional 3 months without dietary prescriptions or calcium supplements, a subgroup of 48 subjects (24 from each group) were scanned again using DXA. There was a significant decrease in TBBM after 1 month and 3 months. A similar pattern was observed in the bone mineral content (BMC) of the lumbar spine in the patients who did not receive a calcium supplement, whereas no changes occurred in the supplemented group. The initial calcium supplementation seemed to protect against bone loss in the lumbar spine but not in the TBBM. In the nonsupplemented group, a statistically significant inverse correlation was found between the calcium/creatinine ratio in the morning urine and the changes in BMC of the lumbar spine. Such a relationship was not seen in the calcium-supplemented group. In the nonsupplemented group, no significant biochemical changes were observed, whereas a significant decrease in serum parathyroid hormone (PTH) was seen in the calcium-supplemented group. This might explain some of the protective effects of calcium supplementation on trabecular bone mass. We conclude that a diet-induced weight loss is accompanied by a generalized bone loss, which probably is explained mainly by a reduced mechanical strain on the skeleton. This loss can be partly inhibited by a high calcium intake. Therefore, a calcium supplementation should be recommended during weight loss, even if the diet contains the officially recommended amounts of calcium.

Authors+Show Affiliations

Osteoporosis Research Center, Hovedstadens Sygehusfaelleskab Hvidovre Hospital, Copenhagen, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

11149478

Citation

Jensen, L B., et al. "Bone Minerals Changes in Obese Women During a Moderate Weight Loss With and Without Calcium Supplementation." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, vol. 16, no. 1, 2001, pp. 141-7.
Jensen LB, Kollerup G, Quaade F, et al. Bone minerals changes in obese women during a moderate weight loss with and without calcium supplementation. J Bone Miner Res. 2001;16(1):141-7.
Jensen, L. B., Kollerup, G., Quaade, F., & Sørensen, O. H. (2001). Bone minerals changes in obese women during a moderate weight loss with and without calcium supplementation. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 16(1), pp. 141-7.
Jensen LB, et al. Bone Minerals Changes in Obese Women During a Moderate Weight Loss With and Without Calcium Supplementation. J Bone Miner Res. 2001;16(1):141-7. PubMed PMID: 11149478.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bone minerals changes in obese women during a moderate weight loss with and without calcium supplementation. AU - Jensen,L B, AU - Kollerup,G, AU - Quaade,F, AU - Sørensen,O H, PY - 2001/1/10/pubmed PY - 2001/3/7/medline PY - 2001/1/10/entrez SP - 141 EP - 7 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JO - J. Bone Miner. Res. VL - 16 IS - 1 N2 - A significant relationship between body weight (BW) and bone mass (BM) has been established previously. A diet-induced weight loss is accompanied by a significant decrease in bone mineral density (BMD) and total body bone mineral (TBBM), but the underlying mechanisms are not clarified. Sixty-two obese women were included in the study. Dual-energy X-ray absorptiometry (DXA) and measurements of a series of calcium-regulating hormones and biochemical markers of bone turnover were performed at baseline and after 1 month and 3 months on a low calorie diet. Thirty of the women were randomized to a daily supplement of 1 g of calcium. After an additional 3 months without dietary prescriptions or calcium supplements, a subgroup of 48 subjects (24 from each group) were scanned again using DXA. There was a significant decrease in TBBM after 1 month and 3 months. A similar pattern was observed in the bone mineral content (BMC) of the lumbar spine in the patients who did not receive a calcium supplement, whereas no changes occurred in the supplemented group. The initial calcium supplementation seemed to protect against bone loss in the lumbar spine but not in the TBBM. In the nonsupplemented group, a statistically significant inverse correlation was found between the calcium/creatinine ratio in the morning urine and the changes in BMC of the lumbar spine. Such a relationship was not seen in the calcium-supplemented group. In the nonsupplemented group, no significant biochemical changes were observed, whereas a significant decrease in serum parathyroid hormone (PTH) was seen in the calcium-supplemented group. This might explain some of the protective effects of calcium supplementation on trabecular bone mass. We conclude that a diet-induced weight loss is accompanied by a generalized bone loss, which probably is explained mainly by a reduced mechanical strain on the skeleton. This loss can be partly inhibited by a high calcium intake. Therefore, a calcium supplementation should be recommended during weight loss, even if the diet contains the officially recommended amounts of calcium. SN - 0884-0431 UR - https://www.unboundmedicine.com/medline/citation/11149478/Bone_minerals_changes_in_obese_women_during_a_moderate_weight_loss_with_and_without_calcium_supplementation_ L2 - https://doi.org/10.1359/jbmr.2001.16.1.141 DB - PRIME DP - Unbound Medicine ER -