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The evaluation of subatmospheric pressure and hyperbaric oxygen in ischemic full-thickness wound healing.
Am Surg 2000; 66(12):1136-43AS

Abstract

We evaluated the efficacy of subatmospheric pressure and hyperbaric oxygen (HBO) as adjuncts in the treatment of hypoxic full-thickness wounds in a rabbit model. We hypothesized that subatmospheric pressure and HBO independently are effective in improving wound healing in the ischemic wound model and that when they are used in combination there is an increased positive effect on wound healing. Using a standard ischemic wound model four full-thickness wounds were created on each ear of 41 male New Zealand white rabbits (N = 82 ears). On each rabbit one ear was dressed with the vacuum-assisted closure (VAC) device and connected to suction; the other was dressed identically without the suction and suction tubing. Twenty rabbits were treated with HBO daily for 10 days at 2.0 atmospheres absolute for 90 minutes plus descent and ascent times. Necropsy on all rabbits was performed on postoperative day 10. Four ischemic wound treatment groups were evaluated: Group 1 (N = 21) VAC dressing alone; Group 2 (N = 20) VAC dressing plus HBO; Group 3 (N = 21) VAC dressing to suction alone; and Group 4 (N = 20) VAC dressing to suction and HBO. Using light microscopy a veterinary pathologist blinded to treatment groups quantified peak granulation tissue, granulation tissue gap, and epithelialization tissue gap. Data were analyzed by analysis of variance with significance indicated by P < 0.05. Statistical significance was found in a comparison of VAC dressing to suction and VAC dressing alone for peak granulation tissue and granulation tissue gap both with and without use of HBO. VAC device use appears to increase the rate of healing in a rabbit ischemic wound model. HBO therapy did not significantly affect the rate of healing in this model.

Authors+Show Affiliations

Department of Surgery, University of Tennessee College of Medicine, Chattanooga, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11149585

Citation

Fabian, T S., et al. "The Evaluation of Subatmospheric Pressure and Hyperbaric Oxygen in Ischemic Full-thickness Wound Healing." The American Surgeon, vol. 66, no. 12, 2000, pp. 1136-43.
Fabian TS, Kaufman HJ, Lett ED, et al. The evaluation of subatmospheric pressure and hyperbaric oxygen in ischemic full-thickness wound healing. Am Surg. 2000;66(12):1136-43.
Fabian, T. S., Kaufman, H. J., Lett, E. D., Thomas, J. B., Rawl, D. K., Lewis, P. L., ... Burns, R. P. (2000). The evaluation of subatmospheric pressure and hyperbaric oxygen in ischemic full-thickness wound healing. The American Surgeon, 66(12), pp. 1136-43.
Fabian TS, et al. The Evaluation of Subatmospheric Pressure and Hyperbaric Oxygen in Ischemic Full-thickness Wound Healing. Am Surg. 2000;66(12):1136-43. PubMed PMID: 11149585.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The evaluation of subatmospheric pressure and hyperbaric oxygen in ischemic full-thickness wound healing. AU - Fabian,T S, AU - Kaufman,H J, AU - Lett,E D, AU - Thomas,J B, AU - Rawl,D K, AU - Lewis,P L, AU - Summitt,J B, AU - Merryman,J I, AU - Schaeffer,T D, AU - Sargent,L A, AU - Burns,R P, PY - 2001/1/10/pubmed PY - 2001/2/28/medline PY - 2001/1/10/entrez SP - 1136 EP - 43 JF - The American surgeon JO - Am Surg VL - 66 IS - 12 N2 - We evaluated the efficacy of subatmospheric pressure and hyperbaric oxygen (HBO) as adjuncts in the treatment of hypoxic full-thickness wounds in a rabbit model. We hypothesized that subatmospheric pressure and HBO independently are effective in improving wound healing in the ischemic wound model and that when they are used in combination there is an increased positive effect on wound healing. Using a standard ischemic wound model four full-thickness wounds were created on each ear of 41 male New Zealand white rabbits (N = 82 ears). On each rabbit one ear was dressed with the vacuum-assisted closure (VAC) device and connected to suction; the other was dressed identically without the suction and suction tubing. Twenty rabbits were treated with HBO daily for 10 days at 2.0 atmospheres absolute for 90 minutes plus descent and ascent times. Necropsy on all rabbits was performed on postoperative day 10. Four ischemic wound treatment groups were evaluated: Group 1 (N = 21) VAC dressing alone; Group 2 (N = 20) VAC dressing plus HBO; Group 3 (N = 21) VAC dressing to suction alone; and Group 4 (N = 20) VAC dressing to suction and HBO. Using light microscopy a veterinary pathologist blinded to treatment groups quantified peak granulation tissue, granulation tissue gap, and epithelialization tissue gap. Data were analyzed by analysis of variance with significance indicated by P < 0.05. Statistical significance was found in a comparison of VAC dressing to suction and VAC dressing alone for peak granulation tissue and granulation tissue gap both with and without use of HBO. VAC device use appears to increase the rate of healing in a rabbit ischemic wound model. HBO therapy did not significantly affect the rate of healing in this model. SN - 0003-1348 UR - https://www.unboundmedicine.com/medline/citation/11149585/The_evaluation_of_subatmospheric_pressure_and_hyperbaric_oxygen_in_ischemic_full_thickness_wound_healing_ L2 - https://medlineplus.gov/woundsandinjuries.html DB - PRIME DP - Unbound Medicine ER -