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Reactive oxygen radicals in signaling and damage in the ischemic brain.
J Cereb Blood Flow Metab. 2001 Jan; 21(1):2-14.JC

Abstract

Reactive oxygen species have been implicated in brain injury after ischemic stroke. These oxidants can react and damage the cellular macromolecules by virtue of the reactivity that leads to cell injury and necrosis. Oxidants are also mediators in signaling involving mitochondria, DNA repair enzymes, and transcription factors that may lead to apoptosis after cerebral ischemia. Transgenic or knockout mice with cell- or site-specific prooxidant and antioxidant enzymes provide useful tools in dissecting the events involving oxidative stress in signaling and damage in ischemic brain injury.

Authors+Show Affiliations

Department of Neurosurgery, Stanford University School of Medicine, California 94205-5487, USA.

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

11149664

Citation

Chan, P H.. "Reactive Oxygen Radicals in Signaling and Damage in the Ischemic Brain." Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism, vol. 21, no. 1, 2001, pp. 2-14.
Chan PH. Reactive oxygen radicals in signaling and damage in the ischemic brain. J Cereb Blood Flow Metab. 2001;21(1):2-14.
Chan, P. H. (2001). Reactive oxygen radicals in signaling and damage in the ischemic brain. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism, 21(1), 2-14.
Chan PH. Reactive Oxygen Radicals in Signaling and Damage in the Ischemic Brain. J Cereb Blood Flow Metab. 2001;21(1):2-14. PubMed PMID: 11149664.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reactive oxygen radicals in signaling and damage in the ischemic brain. A1 - Chan,P H, PY - 2001/1/10/pubmed PY - 2001/4/6/medline PY - 2001/1/10/entrez SP - 2 EP - 14 JF - Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism JO - J Cereb Blood Flow Metab VL - 21 IS - 1 N2 - Reactive oxygen species have been implicated in brain injury after ischemic stroke. These oxidants can react and damage the cellular macromolecules by virtue of the reactivity that leads to cell injury and necrosis. Oxidants are also mediators in signaling involving mitochondria, DNA repair enzymes, and transcription factors that may lead to apoptosis after cerebral ischemia. Transgenic or knockout mice with cell- or site-specific prooxidant and antioxidant enzymes provide useful tools in dissecting the events involving oxidative stress in signaling and damage in ischemic brain injury. SN - 0271-678X UR - https://www.unboundmedicine.com/medline/citation/11149664/Reactive_oxygen_radicals_in_signaling_and_damage_in_the_ischemic_brain_ L2 - https://journals.sagepub.com/doi/10.1097/00004647-200101000-00002?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -