Tags

Type your tag names separated by a space and hit enter

Micronized purified flavonoid fraction and the treatment of chronic venous insufficiency: microcirculatory mechanisms.
Microcirculation. 2000; 7(6 Pt 2):S35-40.M

Abstract

The standard treatments for venous diseases of the lower limb include compression bandaging and stockings as well as surgical removal of varicose veins. There is a number of conditions in which these conventional treatments are ineffective, particularly in the management of leg ulceration. Drug treatments for healing venous leg ulcers have yet to be developed to the stage of good clinical efficacy, but may assist in the management of patients. Flavonoid drugs have been widely used in the management of the symptoms of venous disease for many years and have recently been studied in some detail to assess their effects on the microcirculation. Work in animal models of ischemia/reperfusion (I/R) show that micronized purified flavonoid fraction (MPFF) modulates leukocyte adhesion and prevents endothelial damage. Similar biochemical effects have been observed in patients with venous disease and may explain the efficacy of this drug in the management of edema and other symptoms of venous disease. There is some evidence that MPFF promotes venous leg ulcer healing.

Authors+Show Affiliations

Royal Free and University College Medical School, London, UK. p.coleridgesmith@ucl.ac.uk

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11151970

Citation

Smith, P D.. "Micronized Purified Flavonoid Fraction and the Treatment of Chronic Venous Insufficiency: Microcirculatory Mechanisms." Microcirculation (New York, N.Y. : 1994), vol. 7, no. 6 Pt 2, 2000, pp. S35-40.
Smith PD. Micronized purified flavonoid fraction and the treatment of chronic venous insufficiency: microcirculatory mechanisms. Microcirculation. 2000;7(6 Pt 2):S35-40.
Smith, P. D. (2000). Micronized purified flavonoid fraction and the treatment of chronic venous insufficiency: microcirculatory mechanisms. Microcirculation (New York, N.Y. : 1994), 7(6 Pt 2), S35-40.
Smith PD. Micronized Purified Flavonoid Fraction and the Treatment of Chronic Venous Insufficiency: Microcirculatory Mechanisms. Microcirculation. 2000;7(6 Pt 2):S35-40. PubMed PMID: 11151970.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Micronized purified flavonoid fraction and the treatment of chronic venous insufficiency: microcirculatory mechanisms. A1 - Smith,P D, PY - 2001/1/11/pubmed PY - 2001/3/27/medline PY - 2001/1/11/entrez SP - S35 EP - 40 JF - Microcirculation (New York, N.Y. : 1994) JO - Microcirculation VL - 7 IS - 6 Pt 2 N2 - The standard treatments for venous diseases of the lower limb include compression bandaging and stockings as well as surgical removal of varicose veins. There is a number of conditions in which these conventional treatments are ineffective, particularly in the management of leg ulceration. Drug treatments for healing venous leg ulcers have yet to be developed to the stage of good clinical efficacy, but may assist in the management of patients. Flavonoid drugs have been widely used in the management of the symptoms of venous disease for many years and have recently been studied in some detail to assess their effects on the microcirculation. Work in animal models of ischemia/reperfusion (I/R) show that micronized purified flavonoid fraction (MPFF) modulates leukocyte adhesion and prevents endothelial damage. Similar biochemical effects have been observed in patients with venous disease and may explain the efficacy of this drug in the management of edema and other symptoms of venous disease. There is some evidence that MPFF promotes venous leg ulcer healing. SN - 1073-9688 UR - https://www.unboundmedicine.com/medline/citation/11151970/Micronized_purified_flavonoid_fraction_and_the_treatment_of_chronic_venous_insufficiency:_microcirculatory_mechanisms_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1073-9688&date=2000&volume=7&issue=6 Pt 2&spage=S35 DB - PRIME DP - Unbound Medicine ER -