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Soy intake related to menopausal symptoms, serum lipids, and bone mineral density in postmenopausal Japanese women.
Obstet Gynecol 2001; 97(1):109-15OG

Abstract

OBJECTIVE

To evaluate the effects of dietary isoflavones in soy products on menopausal symptoms, lipid profiles, and bone mineral densities in postmenopausal Japanese women.

METHODS

We estimated the daily intakes of isoflavones in the diets of 478 postmenopausal Japanese women who reported soy consumption. We recorded serum values of fasting total cholesterol, triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and apolipoproteins. Bone mineral density was measured at the lumbar spine (L2-L4) by dual energy x-ray absorptiometry. Women were assigned to two groups according to years since menopause (early and late postmenopausal groups), and each group was subcategorized into four groups according to dietary isoflavone intake. Relationships between isoflavone intake, menopausal symptoms, lipid profiles, and bone mineral density were examined in each group.

RESULTS

The mean estimated intake of isoflavones among 478 women was 54.3 mg/day. With stepwise regression analysis we found that weight and years since menopause were significant independent predictors of bone mineral density. Bone mineral densities adjusted to years since menopause and weight were significantly different in the highest intake compared with lowest intake category (P <.001) within the early and late postmenopausal groups. In the early postmenopausal group, significant differences were found in palpitation and backaches between the high and low intake categories but were not significant in the late postmenopausal group.

CONCLUSION

High consumption of soy products is associated with increased bone mass in postmenopausal women and might be useful for preventing hypoestrogenic effects.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Toride Kyodo General Hospital, Toride, Ibaraki, Japan. pv2t-sigi@asahi-net.or.jpNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11152918

Citation

Somekawa, Y, et al. "Soy Intake Related to Menopausal Symptoms, Serum Lipids, and Bone Mineral Density in Postmenopausal Japanese Women." Obstetrics and Gynecology, vol. 97, no. 1, 2001, pp. 109-15.
Somekawa Y, Chiguchi M, Ishibashi T, et al. Soy intake related to menopausal symptoms, serum lipids, and bone mineral density in postmenopausal Japanese women. Obstet Gynecol. 2001;97(1):109-15.
Somekawa, Y., Chiguchi, M., Ishibashi, T., & Aso, T. (2001). Soy intake related to menopausal symptoms, serum lipids, and bone mineral density in postmenopausal Japanese women. Obstetrics and Gynecology, 97(1), pp. 109-15.
Somekawa Y, et al. Soy Intake Related to Menopausal Symptoms, Serum Lipids, and Bone Mineral Density in Postmenopausal Japanese Women. Obstet Gynecol. 2001;97(1):109-15. PubMed PMID: 11152918.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soy intake related to menopausal symptoms, serum lipids, and bone mineral density in postmenopausal Japanese women. AU - Somekawa,Y, AU - Chiguchi,M, AU - Ishibashi,T, AU - Aso,T, PY - 2001/1/12/pubmed PY - 2001/3/3/medline PY - 2001/1/12/entrez SP - 109 EP - 15 JF - Obstetrics and gynecology JO - Obstet Gynecol VL - 97 IS - 1 N2 - OBJECTIVE: To evaluate the effects of dietary isoflavones in soy products on menopausal symptoms, lipid profiles, and bone mineral densities in postmenopausal Japanese women. METHODS: We estimated the daily intakes of isoflavones in the diets of 478 postmenopausal Japanese women who reported soy consumption. We recorded serum values of fasting total cholesterol, triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and apolipoproteins. Bone mineral density was measured at the lumbar spine (L2-L4) by dual energy x-ray absorptiometry. Women were assigned to two groups according to years since menopause (early and late postmenopausal groups), and each group was subcategorized into four groups according to dietary isoflavone intake. Relationships between isoflavone intake, menopausal symptoms, lipid profiles, and bone mineral density were examined in each group. RESULTS: The mean estimated intake of isoflavones among 478 women was 54.3 mg/day. With stepwise regression analysis we found that weight and years since menopause were significant independent predictors of bone mineral density. Bone mineral densities adjusted to years since menopause and weight were significantly different in the highest intake compared with lowest intake category (P <.001) within the early and late postmenopausal groups. In the early postmenopausal group, significant differences were found in palpitation and backaches between the high and low intake categories but were not significant in the late postmenopausal group. CONCLUSION: High consumption of soy products is associated with increased bone mass in postmenopausal women and might be useful for preventing hypoestrogenic effects. SN - 0029-7844 UR - https://www.unboundmedicine.com/medline/citation/11152918/Soy_intake_related_to_menopausal_symptoms_serum_lipids_and_bone_mineral_density_in_postmenopausal_Japanese_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0029-7844(00)01080-2 DB - PRIME DP - Unbound Medicine ER -