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Plasma C-peptide and diagnosis of factitious hyperinsulinism. Study of an insulin-dependent diabetic patient with "spontaneous" hypoglycemia.
Ann Intern Med. 1975 Feb; 82(2):201-4.AIM

Abstract

Factitious hyperinsulinism was suspected in a patient with an 11-year history of insulin-dependent, ketosis-prone diabetes mellitus who began to experience repetitive episodes of "spontaneous" hypoglycemia. Insulin mediation of the hypoglycemia was confirmed by documenting that urinary insulin and total extractable insulin in plasma increased during periods of hypoglycemia. Failure to detect significant amounts of human C-peptide by radioimmunoassay during periods of hypoglycemia or in response to stimulation with glucagon, leucine, or tolbutamide indicated that the insulin was not endogenous. The diagnosis of factitious hyperinsulinism was ultimately proved by the finding of radioactivity in the patient's urine after 131-I Hippuran was added to a vial of insulin found in the patient's room.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1115442

Citation

Couropmitree, C, et al. "Plasma C-peptide and Diagnosis of Factitious Hyperinsulinism. Study of an Insulin-dependent Diabetic Patient With "spontaneous" Hypoglycemia." Annals of Internal Medicine, vol. 82, no. 2, 1975, pp. 201-4.
Couropmitree C, Freinkel N, Nagel TC, et al. Plasma C-peptide and diagnosis of factitious hyperinsulinism. Study of an insulin-dependent diabetic patient with "spontaneous" hypoglycemia. Ann Intern Med. 1975;82(2):201-4.
Couropmitree, C., Freinkel, N., Nagel, T. C., Horwitz, D. L., Rubenstein, A. H., Metzger, B., Rubenstein, A. H., & Hahnel, R. (1975). Plasma C-peptide and diagnosis of factitious hyperinsulinism. Study of an insulin-dependent diabetic patient with "spontaneous" hypoglycemia. Annals of Internal Medicine, 82(2), 201-4.
Couropmitree C, et al. Plasma C-peptide and Diagnosis of Factitious Hyperinsulinism. Study of an Insulin-dependent Diabetic Patient With "spontaneous" Hypoglycemia. Ann Intern Med. 1975;82(2):201-4. PubMed PMID: 1115442.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma C-peptide and diagnosis of factitious hyperinsulinism. Study of an insulin-dependent diabetic patient with "spontaneous" hypoglycemia. AU - Couropmitree,C, AU - Freinkel,N, AU - Nagel,T C, AU - Horwitz,D L, AU - Rubenstein,A H, AU - Metzger,B, AU - Rubenstein,A H, AU - Hahnel,R, PY - 1975/2/1/pubmed PY - 1975/2/1/medline PY - 1975/2/1/entrez SP - 201 EP - 4 JF - Annals of internal medicine JO - Ann Intern Med VL - 82 IS - 2 N2 - Factitious hyperinsulinism was suspected in a patient with an 11-year history of insulin-dependent, ketosis-prone diabetes mellitus who began to experience repetitive episodes of "spontaneous" hypoglycemia. Insulin mediation of the hypoglycemia was confirmed by documenting that urinary insulin and total extractable insulin in plasma increased during periods of hypoglycemia. Failure to detect significant amounts of human C-peptide by radioimmunoassay during periods of hypoglycemia or in response to stimulation with glucagon, leucine, or tolbutamide indicated that the insulin was not endogenous. The diagnosis of factitious hyperinsulinism was ultimately proved by the finding of radioactivity in the patient's urine after 131-I Hippuran was added to a vial of insulin found in the patient's room. SN - 0003-4819 UR - https://www.unboundmedicine.com/medline/citation/1115442/Plasma_C_peptide_and_diagnosis_of_factitious_hyperinsulinism__Study_of_an_insulin_dependent_diabetic_patient_with_"spontaneous"_hypoglycemia_ L2 - https://www.acpjournals.org/doi/10.7326/0003-4819-82-2-201?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -