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Overexpression of CuZnSOD gene suppresses the growth of hepatocellular cancer cell line HepG2.
Chin Med J (Engl). 1998 Sep; 111(9):789-92.CM

Abstract

OBJECTIVE

To explore the inhibiting effect of superoxide dismutase (SOD) on the growth of hepatocellular cancer cell line HepG2.

METHODS

By gene transfer technique, hepatocellular cancer cells (HepG2) were transfected with a retroviral vector containing human CuZnSOD cDNA. The elevated SOD gene expression of the transfected cells was compared with the parental and neo control cells.

RESULTS

Compared to the control cells, cancer cells transfected with SOD gene showed an inhibited cell growth, a reduced number of cells in S phase and decreased clone forming ability in soft agar, as well as a smaller tumor size formed in nude mice.

CONCLUSION

The overexpression of CuZnSOD gene could, to certain extent, suppress the cell growth of hepatocellular cancer cell line HepG2.

Authors+Show Affiliations

Department of Surgery, People's Hospital, Beijing Medical University, Beijing 100044, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11155667

Citation

Bai, J, et al. "Overexpression of CuZnSOD Gene Suppresses the Growth of Hepatocellular Cancer Cell Line HepG2." Chinese Medical Journal, vol. 111, no. 9, 1998, pp. 789-92.
Bai J, Zhu X, Zheng X, et al. Overexpression of CuZnSOD gene suppresses the growth of hepatocellular cancer cell line HepG2. Chin Med J (Engl). 1998;111(9):789-92.
Bai, J., Zhu, X., Zheng, X., & Wu, Y. (1998). Overexpression of CuZnSOD gene suppresses the growth of hepatocellular cancer cell line HepG2. Chinese Medical Journal, 111(9), 789-92.
Bai J, et al. Overexpression of CuZnSOD Gene Suppresses the Growth of Hepatocellular Cancer Cell Line HepG2. Chin Med J (Engl). 1998;111(9):789-92. PubMed PMID: 11155667.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Overexpression of CuZnSOD gene suppresses the growth of hepatocellular cancer cell line HepG2. AU - Bai,J, AU - Zhu,X, AU - Zheng,X, AU - Wu,Y, PY - 2001/1/13/pubmed PY - 2001/3/7/medline PY - 2001/1/13/entrez SP - 789 EP - 92 JF - Chinese medical journal JO - Chin Med J (Engl) VL - 111 IS - 9 N2 - OBJECTIVE: To explore the inhibiting effect of superoxide dismutase (SOD) on the growth of hepatocellular cancer cell line HepG2. METHODS: By gene transfer technique, hepatocellular cancer cells (HepG2) were transfected with a retroviral vector containing human CuZnSOD cDNA. The elevated SOD gene expression of the transfected cells was compared with the parental and neo control cells. RESULTS: Compared to the control cells, cancer cells transfected with SOD gene showed an inhibited cell growth, a reduced number of cells in S phase and decreased clone forming ability in soft agar, as well as a smaller tumor size formed in nude mice. CONCLUSION: The overexpression of CuZnSOD gene could, to certain extent, suppress the cell growth of hepatocellular cancer cell line HepG2. SN - 0366-6999 UR - https://www.unboundmedicine.com/medline/citation/11155667/Overexpression_of_CuZnSOD_gene_suppresses_the_growth_of_hepatocellular_cancer_cell_line_HepG2_ L2 - https://medlineplus.gov/livercancer.html DB - PRIME DP - Unbound Medicine ER -