Tags

Type your tag names separated by a space and hit enter

Effect of gynostemma pentaphyllum mak on carcinomatous conversions of golden hamster cheek pouches induced by dimethylbenzanthracene: a histological study.
Chin Med J (Engl). 1998 Sep; 111(9):847-50.CM

Abstract

OBJECTIVE

To evaluate the effect of gynostemma pentaphyllum mak (GP) on carcinomatous conversions of leukoplasia of the golden hamster cheek pouch induced by dimethylbenzanthracene (DMBA).

METHODS

284 golden hamsters, ranging from 4 to 8 weeks of age, 80 to 100 grams in weight were randomly divided into three groups: control, model and experimental groups. Control group (8 hamsters) were sacrificed at week 0 and week 12 for control. Model group (123 hamsters) were pasted in bilateral cheek pouches with 0.5% DMBA, 3 times a week for establishment of experimental leukoplasia, and sacrificed at week 2 to week 9 (12-22 hamsters were sacrificed a week). Experimental group (153 hamsters) were divided into three subgroups. Subgroup A underwent simultaneous DMBA pasting and oral taking of GP, and were sacrificed at week 6 and week 9. Subgroup B underwent oral taking of GP for 12 weeks after completion of DMBA pasting. Subgroup C underwent DMBA pasting after completion of oral taking of GP for 12 weeks.

RESULTS

The earliest epithelial dysplasia and carcinoma in situ occurred at week 3 and week 6 after DMBA pasting. There were significant differences between subgroup B and model group for 3 weeks' administration of DMBA (P < 0.05), and between subgroup C and model group (P < 0.01), while there was no difference between subgroup B and model group for 6 week's administration of DMBA (P > 0.05).

CONCLUSIONS

GP could inhibit and reverse the carcinomatous conversions of leukoplasia of golden hamster cheek pouches, indicating its positive anticarcinogenic effect.

Authors+Show Affiliations

School of Stomatology, Shanghai Second Medical University, Shanghai 200011, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11155680

Citation

Zhou, Z, et al. "Effect of Gynostemma Pentaphyllum Mak On Carcinomatous Conversions of Golden Hamster Cheek Pouches Induced By Dimethylbenzanthracene: a Histological Study." Chinese Medical Journal, vol. 111, no. 9, 1998, pp. 847-50.
Zhou Z, Wang Y, Zhou Y, et al. Effect of gynostemma pentaphyllum mak on carcinomatous conversions of golden hamster cheek pouches induced by dimethylbenzanthracene: a histological study. Chin Med J. 1998;111(9):847-50.
Zhou, Z., Wang, Y., Zhou, Y., & Zhang, S. (1998). Effect of gynostemma pentaphyllum mak on carcinomatous conversions of golden hamster cheek pouches induced by dimethylbenzanthracene: a histological study. Chinese Medical Journal, 111(9), 847-50.
Zhou Z, et al. Effect of Gynostemma Pentaphyllum Mak On Carcinomatous Conversions of Golden Hamster Cheek Pouches Induced By Dimethylbenzanthracene: a Histological Study. Chin Med J. 1998;111(9):847-50. PubMed PMID: 11155680.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of gynostemma pentaphyllum mak on carcinomatous conversions of golden hamster cheek pouches induced by dimethylbenzanthracene: a histological study. AU - Zhou,Z, AU - Wang,Y, AU - Zhou,Y, AU - Zhang,S, PY - 2001/1/13/pubmed PY - 2001/3/7/medline PY - 2001/1/13/entrez SP - 847 EP - 50 JF - Chinese medical journal JO - Chin. Med. J. VL - 111 IS - 9 N2 - OBJECTIVE: To evaluate the effect of gynostemma pentaphyllum mak (GP) on carcinomatous conversions of leukoplasia of the golden hamster cheek pouch induced by dimethylbenzanthracene (DMBA). METHODS: 284 golden hamsters, ranging from 4 to 8 weeks of age, 80 to 100 grams in weight were randomly divided into three groups: control, model and experimental groups. Control group (8 hamsters) were sacrificed at week 0 and week 12 for control. Model group (123 hamsters) were pasted in bilateral cheek pouches with 0.5% DMBA, 3 times a week for establishment of experimental leukoplasia, and sacrificed at week 2 to week 9 (12-22 hamsters were sacrificed a week). Experimental group (153 hamsters) were divided into three subgroups. Subgroup A underwent simultaneous DMBA pasting and oral taking of GP, and were sacrificed at week 6 and week 9. Subgroup B underwent oral taking of GP for 12 weeks after completion of DMBA pasting. Subgroup C underwent DMBA pasting after completion of oral taking of GP for 12 weeks. RESULTS: The earliest epithelial dysplasia and carcinoma in situ occurred at week 3 and week 6 after DMBA pasting. There were significant differences between subgroup B and model group for 3 weeks' administration of DMBA (P < 0.05), and between subgroup C and model group (P < 0.01), while there was no difference between subgroup B and model group for 6 week's administration of DMBA (P > 0.05). CONCLUSIONS: GP could inhibit and reverse the carcinomatous conversions of leukoplasia of golden hamster cheek pouches, indicating its positive anticarcinogenic effect. SN - 0366-6999 UR - https://www.unboundmedicine.com/medline/citation/11155680/Effect_of_gynostemma_pentaphyllum_mak_on_carcinomatous_conversions_of_golden_hamster_cheek_pouches_induced_by_dimethylbenzanthracene:_a_histological_study_ L2 - https://www.lens.org/lens/search?q=citation_id:11155680 DB - PRIME DP - Unbound Medicine ER -