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Genetic, dietary, and other lifestyle determinants of plasma homocysteine concentrations in middle-aged and older Chinese men and women in Singapore.
Am J Clin Nutr 2001; 73(2):232-9AJ

Abstract

BACKGROUND

Epidemiologic studies have identified the plasma homocysteine concentration as a risk factor for atherothrombotic vascular disease. There is little information on the distributions and determinants of homocysteine concentrations in Asian populations.

OBJECTIVE

The present study was designed to examine the relations between genetic and lifestyle factors and plasma homocysteine concentrations among Chinese in Singapore.

DESIGN

Plasma total homocysteine, folate, vitamin B-12, and vitamin B-6 concentrations and genetic variation at the methylenetetrahydrofolate reductase (MTHFR) locus were measured in 486 Chinese men and women aged 45-74 y in Singapore. Data on dietary and other lifestyle factors were collected in face-to-face interviews.

RESULTS

Men had higher plasma concentrations of total homocysteine than women (P = 0.0001). Age was positively associated with plasma homocysteine in both sexes (P for trend = 0.0001). Plasma concentrations of folate, vitamin B-12, and vitamin B-6 were inversely associated with homocysteine concentrations. Among individuals with low plasma folate, those possessing 2 copies of MTHFR mutant alleles had significantly higher homocysteine concentrations than did those with > or = 1 copy of the wild-type allele. Cigarette smoking, daily coffee consumption, and physical inactivity were positively related to plasma homocysteine concentrations in both sexes (P < 0.05). However, these associations disappeared after adjustment for plasma folate concentrations.

CONCLUSIONS

Age, sex, plasma folate, vitamin B-12 and B-6 concentrations, and MTHFR genotype are independent determinants of plasma homocysteine in middle-aged and older Chinese in Singapore. These factors combined could account for up to 40% of the total variation in homocysteine concentrations in this Asian population.

Authors+Show Affiliations

Department of Community, Occupational, and Family Medicine, National University of Singapore.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11157318

Citation

Saw, S M., et al. "Genetic, Dietary, and Other Lifestyle Determinants of Plasma Homocysteine Concentrations in Middle-aged and Older Chinese Men and Women in Singapore." The American Journal of Clinical Nutrition, vol. 73, no. 2, 2001, pp. 232-9.
Saw SM, Yuan JM, Ong CN, et al. Genetic, dietary, and other lifestyle determinants of plasma homocysteine concentrations in middle-aged and older Chinese men and women in Singapore. Am J Clin Nutr. 2001;73(2):232-9.
Saw, S. M., Yuan, J. M., Ong, C. N., Arakawa, K., Lee, H. P., Coetzee, G. A., & Yu, M. C. (2001). Genetic, dietary, and other lifestyle determinants of plasma homocysteine concentrations in middle-aged and older Chinese men and women in Singapore. The American Journal of Clinical Nutrition, 73(2), pp. 232-9.
Saw SM, et al. Genetic, Dietary, and Other Lifestyle Determinants of Plasma Homocysteine Concentrations in Middle-aged and Older Chinese Men and Women in Singapore. Am J Clin Nutr. 2001;73(2):232-9. PubMed PMID: 11157318.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic, dietary, and other lifestyle determinants of plasma homocysteine concentrations in middle-aged and older Chinese men and women in Singapore. AU - Saw,S M, AU - Yuan,J M, AU - Ong,C N, AU - Arakawa,K, AU - Lee,H P, AU - Coetzee,G A, AU - Yu,M C, PY - 2001/2/7/pubmed PY - 2001/3/17/medline PY - 2001/2/7/entrez SP - 232 EP - 9 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 73 IS - 2 N2 - BACKGROUND: Epidemiologic studies have identified the plasma homocysteine concentration as a risk factor for atherothrombotic vascular disease. There is little information on the distributions and determinants of homocysteine concentrations in Asian populations. OBJECTIVE: The present study was designed to examine the relations between genetic and lifestyle factors and plasma homocysteine concentrations among Chinese in Singapore. DESIGN: Plasma total homocysteine, folate, vitamin B-12, and vitamin B-6 concentrations and genetic variation at the methylenetetrahydrofolate reductase (MTHFR) locus were measured in 486 Chinese men and women aged 45-74 y in Singapore. Data on dietary and other lifestyle factors were collected in face-to-face interviews. RESULTS: Men had higher plasma concentrations of total homocysteine than women (P = 0.0001). Age was positively associated with plasma homocysteine in both sexes (P for trend = 0.0001). Plasma concentrations of folate, vitamin B-12, and vitamin B-6 were inversely associated with homocysteine concentrations. Among individuals with low plasma folate, those possessing 2 copies of MTHFR mutant alleles had significantly higher homocysteine concentrations than did those with > or = 1 copy of the wild-type allele. Cigarette smoking, daily coffee consumption, and physical inactivity were positively related to plasma homocysteine concentrations in both sexes (P < 0.05). However, these associations disappeared after adjustment for plasma folate concentrations. CONCLUSIONS: Age, sex, plasma folate, vitamin B-12 and B-6 concentrations, and MTHFR genotype are independent determinants of plasma homocysteine in middle-aged and older Chinese in Singapore. These factors combined could account for up to 40% of the total variation in homocysteine concentrations in this Asian population. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/11157318/Genetic_dietary_and_other_lifestyle_determinants_of_plasma_homocysteine_concentrations_in_middle_aged_and_older_Chinese_men_and_women_in_Singapore_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/73.2.232 DB - PRIME DP - Unbound Medicine ER -