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Efficacy and safety of iron sucrose for iron deficiency in patients with dialysis-associated anemia: North American clinical trial.
Am J Kidney Dis. 2001 Feb; 37(2):300-7.AJ

Abstract

Iron sucrose has been used to provide intravenous (IV) iron therapy to patients outside the United States for more than 50 years. In a multicenter North American clinical trial, we determined the efficacy and safety of iron sucrose therapy in patients with dialysis-associated anemia, evidence of iron deficiency, and below-target hemoglobin (Hgb) levels despite epoetin therapy. Evidence of iron deficiency included a transferrin saturation (Tsat) less than 20% and ferritin level less than 300 ng/mL, and below-target Hgb levels included values less than 11.0 g/dL. We administered iron sucrose in 10 doses, each administered undiluted as 100 mg IV push over 5 minutes, without a prior test dose. We assessed efficacy by determining the subsequent change in Hgb, Tsat, and ferritin values. We assessed safety by recording blood pressure and adverse events after iron sucrose injection and comparing results with those for the same patients during an observation control period. Results showed a significant increase in Hgb level that was first evident after three doses of iron sucrose and persisted at least 5 weeks after the 10th dose. Tsat and ferritin levels also increased significantly and remained elevated. In 77 enrolled patients, including those with previous iron dextran sensitivity, other drug allergies, or concurrent angiotensin-converting enzyme inhibitor use, we saw no serious adverse drug reactions and no change in intradialytic blood pressure associated with iron sucrose administration. We conclude that iron sucrose injection administered as 1,000 mg in 10 divided doses by IV push without a prior test dose is safe and effective for the treatment of iron deficiency in patients with dialysis-associated anemia.

Authors+Show Affiliations

Cornell University Medical College, Renal Division, New York Hospital Medical Center of Queens, New York, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11157370

Citation

Charytan, C, et al. "Efficacy and Safety of Iron Sucrose for Iron Deficiency in Patients With Dialysis-associated Anemia: North American Clinical Trial." American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, vol. 37, no. 2, 2001, pp. 300-7.
Charytan C, Levin N, Al-Saloum M, et al. Efficacy and safety of iron sucrose for iron deficiency in patients with dialysis-associated anemia: North American clinical trial. Am J Kidney Dis. 2001;37(2):300-7.
Charytan, C., Levin, N., Al-Saloum, M., Hafeez, T., Gagnon, S., & Van Wyck, D. B. (2001). Efficacy and safety of iron sucrose for iron deficiency in patients with dialysis-associated anemia: North American clinical trial. American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, 37(2), 300-7.
Charytan C, et al. Efficacy and Safety of Iron Sucrose for Iron Deficiency in Patients With Dialysis-associated Anemia: North American Clinical Trial. Am J Kidney Dis. 2001;37(2):300-7. PubMed PMID: 11157370.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy and safety of iron sucrose for iron deficiency in patients with dialysis-associated anemia: North American clinical trial. AU - Charytan,C, AU - Levin,N, AU - Al-Saloum,M, AU - Hafeez,T, AU - Gagnon,S, AU - Van Wyck,D B, PY - 2001/2/7/pubmed PY - 2001/5/22/medline PY - 2001/2/7/entrez SP - 300 EP - 7 JF - American journal of kidney diseases : the official journal of the National Kidney Foundation JO - Am J Kidney Dis VL - 37 IS - 2 N2 - Iron sucrose has been used to provide intravenous (IV) iron therapy to patients outside the United States for more than 50 years. In a multicenter North American clinical trial, we determined the efficacy and safety of iron sucrose therapy in patients with dialysis-associated anemia, evidence of iron deficiency, and below-target hemoglobin (Hgb) levels despite epoetin therapy. Evidence of iron deficiency included a transferrin saturation (Tsat) less than 20% and ferritin level less than 300 ng/mL, and below-target Hgb levels included values less than 11.0 g/dL. We administered iron sucrose in 10 doses, each administered undiluted as 100 mg IV push over 5 minutes, without a prior test dose. We assessed efficacy by determining the subsequent change in Hgb, Tsat, and ferritin values. We assessed safety by recording blood pressure and adverse events after iron sucrose injection and comparing results with those for the same patients during an observation control period. Results showed a significant increase in Hgb level that was first evident after three doses of iron sucrose and persisted at least 5 weeks after the 10th dose. Tsat and ferritin levels also increased significantly and remained elevated. In 77 enrolled patients, including those with previous iron dextran sensitivity, other drug allergies, or concurrent angiotensin-converting enzyme inhibitor use, we saw no serious adverse drug reactions and no change in intradialytic blood pressure associated with iron sucrose administration. We conclude that iron sucrose injection administered as 1,000 mg in 10 divided doses by IV push without a prior test dose is safe and effective for the treatment of iron deficiency in patients with dialysis-associated anemia. SN - 1523-6838 UR - https://www.unboundmedicine.com/medline/citation/11157370/Efficacy_and_safety_of_iron_sucrose_for_iron_deficiency_in_patients_with_dialysis_associated_anemia:_North_American_clinical_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0272-6386(01)55637-1 DB - PRIME DP - Unbound Medicine ER -