Tags

Type your tag names separated by a space and hit enter

Being breastfed in infancy and breast cancer incidence in adult life: results from the two nurses' health studies.

Abstract

Events during perinatal and early life may influence the incidence of breast cancer in adult life, and some case-control studies suggest that having been breastfed may reduce breast cancer risk. The authors studied this association among premenopausal and postmenopausal women by using data from the two Nurses' Health Studies, the Nurses' Health Study (using data from 1992 to 1996) and the Nurses' Health Study II (using data from 1991 to 1997). A history of being breastfed was self-reported by the study participants. During a total of 695,655 person-years, 1,073 cases of invasive breast cancer were diagnosed. The authors did not observe any important overall association between having been breastfed and the development of breast cancer later in life among premenopausal women (covariate-adjusted relative risk = 0.97, 95% confidence interval (CI): 0.78, 1.20) or postmenopausal women (covariate-adjusted relative risk = 1.12, 95% CI: 0.92, 1.37). No significant trend was observed with increasing duration of breastfeeding. The authors also used data on breastfeeding retrospectively collected from 2,103 mothers of participants of the two Nurses' Health Studies. With the mothers' reports, the covariate-adjusted odds ratio of breast cancer was 1.11 (95% CI: 0.88, 1.39) for women who were breastfed compared with those who were not. Data from these two large cohorts do not support the hypothesis that being breastfed confers protection against subsequent breast cancer.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA. kmichels@rics.bwh.harvard.edu

    , , , , , ,

    Source

    American journal of epidemiology 153:3 2001 Feb 01 pg 275-83

    MeSH

    Adult
    Age Factors
    Breast Feeding
    Breast Neoplasms
    Case-Control Studies
    Female
    Follow-Up Studies
    Humans
    Incidence
    Middle Aged
    Odds Ratio
    Postmenopause
    Premenopause
    Prospective Studies

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    11157415

    Citation

    Michels, K B., et al. "Being Breastfed in Infancy and Breast Cancer Incidence in Adult Life: Results From the Two Nurses' Health Studies." American Journal of Epidemiology, vol. 153, no. 3, 2001, pp. 275-83.
    Michels KB, Trichopoulos D, Rosner BA, et al. Being breastfed in infancy and breast cancer incidence in adult life: results from the two nurses' health studies. Am J Epidemiol. 2001;153(3):275-83.
    Michels, K. B., Trichopoulos, D., Rosner, B. A., Hunter, D. J., Colditz, G. A., Hankinson, S. E., ... Willett, W. C. (2001). Being breastfed in infancy and breast cancer incidence in adult life: results from the two nurses' health studies. American Journal of Epidemiology, 153(3), pp. 275-83.
    Michels KB, et al. Being Breastfed in Infancy and Breast Cancer Incidence in Adult Life: Results From the Two Nurses' Health Studies. Am J Epidemiol. 2001 Feb 1;153(3):275-83. PubMed PMID: 11157415.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Being breastfed in infancy and breast cancer incidence in adult life: results from the two nurses' health studies. AU - Michels,K B, AU - Trichopoulos,D, AU - Rosner,B A, AU - Hunter,D J, AU - Colditz,G A, AU - Hankinson,S E, AU - Speizer,F E, AU - Willett,W C, PY - 2001/2/7/pubmed PY - 2001/6/29/medline PY - 2001/2/7/entrez SP - 275 EP - 83 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 153 IS - 3 N2 - Events during perinatal and early life may influence the incidence of breast cancer in adult life, and some case-control studies suggest that having been breastfed may reduce breast cancer risk. The authors studied this association among premenopausal and postmenopausal women by using data from the two Nurses' Health Studies, the Nurses' Health Study (using data from 1992 to 1996) and the Nurses' Health Study II (using data from 1991 to 1997). A history of being breastfed was self-reported by the study participants. During a total of 695,655 person-years, 1,073 cases of invasive breast cancer were diagnosed. The authors did not observe any important overall association between having been breastfed and the development of breast cancer later in life among premenopausal women (covariate-adjusted relative risk = 0.97, 95% confidence interval (CI): 0.78, 1.20) or postmenopausal women (covariate-adjusted relative risk = 1.12, 95% CI: 0.92, 1.37). No significant trend was observed with increasing duration of breastfeeding. The authors also used data on breastfeeding retrospectively collected from 2,103 mothers of participants of the two Nurses' Health Studies. With the mothers' reports, the covariate-adjusted odds ratio of breast cancer was 1.11 (95% CI: 0.88, 1.39) for women who were breastfed compared with those who were not. Data from these two large cohorts do not support the hypothesis that being breastfed confers protection against subsequent breast cancer. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/11157415/Being_breastfed_in_infancy_and_breast_cancer_incidence_in_adult_life:_results_from_the_two_nurses'_health_studies_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/153.3.275 DB - PRIME DP - Unbound Medicine ER -