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Cardiac sympathetic overactivity and decreased baroreflex sensitivity in L-NAME hypertensive rats.
Am J Physiol Heart Circ Physiol. 2001 Feb; 280(2):H844-50.AJ

Abstract

The present study evaluated the possible changes in the autonomic control of heart rate in the hypertensive model induced by the inhibition of nitric oxide synthase. Rats were treated with N(G)-nitro-L-arginine methyl ester (L-NAME group) in the drinking water during 7 days, whereas control groups were treated with tap water (control group) or with the N(G)-nitro-D-arginine methyl ester (D-NAME group), an inactive isomer of the L-NAME molecule. The L-NAME group developed hypertension and tachycardia. The sequential blockade of the autonomic influences with propranolol and methylatropine indicated that the intrinsic heart rate did not differ among groups and revealed a sympathetic overactivity in the control of heart rate in the L-NAME group. The spectral density power of heart rate, calculated using fast-Fourier transformation, indicated a reduced variability in the low-frequency band (0.20-0.60 Hz) for the L-NAME group. The baroreflex sensitivity was also attenuated in these animals when compared with the normotensive control or D-NAME group. Overall, these data indicate cardiac sympathetic overactivity associated with a decreased baroreflex sensitivity in L-NAME hypertensive rats.

Authors+Show Affiliations

Department of Physiology, School of Medicine of Ribeirão Preto, University of São Paulo, 14049-900 Ribeirão Preto, São Paulo, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11158985

Citation

Souza, H C., et al. "Cardiac Sympathetic Overactivity and Decreased Baroreflex Sensitivity in L-NAME Hypertensive Rats." American Journal of Physiology. Heart and Circulatory Physiology, vol. 280, no. 2, 2001, pp. H844-50.
Souza HC, Ballejo G, Salgado MC, et al. Cardiac sympathetic overactivity and decreased baroreflex sensitivity in L-NAME hypertensive rats. Am J Physiol Heart Circ Physiol. 2001;280(2):H844-50.
Souza, H. C., Ballejo, G., Salgado, M. C., Da Silva, V. J., & Salgado, H. C. (2001). Cardiac sympathetic overactivity and decreased baroreflex sensitivity in L-NAME hypertensive rats. American Journal of Physiology. Heart and Circulatory Physiology, 280(2), H844-50.
Souza HC, et al. Cardiac Sympathetic Overactivity and Decreased Baroreflex Sensitivity in L-NAME Hypertensive Rats. Am J Physiol Heart Circ Physiol. 2001;280(2):H844-50. PubMed PMID: 11158985.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiac sympathetic overactivity and decreased baroreflex sensitivity in L-NAME hypertensive rats. AU - Souza,H C, AU - Ballejo,G, AU - Salgado,M C, AU - Da Silva,V J, AU - Salgado,H C, PY - 2001/2/13/pubmed PY - 2001/3/27/medline PY - 2001/2/13/entrez SP - H844 EP - 50 JF - American journal of physiology. Heart and circulatory physiology JO - Am J Physiol Heart Circ Physiol VL - 280 IS - 2 N2 - The present study evaluated the possible changes in the autonomic control of heart rate in the hypertensive model induced by the inhibition of nitric oxide synthase. Rats were treated with N(G)-nitro-L-arginine methyl ester (L-NAME group) in the drinking water during 7 days, whereas control groups were treated with tap water (control group) or with the N(G)-nitro-D-arginine methyl ester (D-NAME group), an inactive isomer of the L-NAME molecule. The L-NAME group developed hypertension and tachycardia. The sequential blockade of the autonomic influences with propranolol and methylatropine indicated that the intrinsic heart rate did not differ among groups and revealed a sympathetic overactivity in the control of heart rate in the L-NAME group. The spectral density power of heart rate, calculated using fast-Fourier transformation, indicated a reduced variability in the low-frequency band (0.20-0.60 Hz) for the L-NAME group. The baroreflex sensitivity was also attenuated in these animals when compared with the normotensive control or D-NAME group. Overall, these data indicate cardiac sympathetic overactivity associated with a decreased baroreflex sensitivity in L-NAME hypertensive rats. SN - 0363-6135 UR - https://www.unboundmedicine.com/medline/citation/11158985/Cardiac_sympathetic_overactivity_and_decreased_baroreflex_sensitivity_in_L_NAME_hypertensive_rats_ L2 - https://journals.physiology.org/doi/10.1152/ajpheart.2001.280.2.H844?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -