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Bone lead and blood lead levels in relation to baseline blood pressure and the prospective development of hypertension: the Normative Aging Study.

Abstract

Between 1991 and 1997, the authors studied 833 participants of the Normative Aging Study in a substudy of bone lead levels (measured by K-shell x-ray fluorescence), blood lead levels, and hypertension. Among these subjects, 337 were classified as normotensive, and 182 and 314 were classified as having borderline and definite hypertension, respectively, at baseline. These bone and blood lead levels were typical of those of community-exposed men. Among the 519 subjects with no history of definite hypertension at baseline, cross-sectional analyses revealed positive associations between systolic blood pressure and bone lead levels. Of the 474 subjects who were free from definite hypertension at baseline and had follow-up data, 74 new cases of definite hypertension were reported. Baseline bone lead levels were positively associated with incidence of hypertension. In proportional hazards models that controlled for age, age squared, body mass index, and family history of hypertension, an increase in patella (trabecular) lead from the midpoint of the lowest quintile to that of the highest quintile was associated with a rate ratio of definite hypertension of 1.71 (95% confidence interval: 1.08, 2.70). No association was found with blood lead level. These results support the hypothesis that cumulative exposure to lead, even at low levels sustained by the general population, may increase the risk of hypertension.

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  • Authors+Show Affiliations

    ,

    Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

    , , , ,

    Source

    American journal of epidemiology 153:2 2001 Jan 15 pg 164-71

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Blood Pressure
    Body Mass Index
    Bone and Bones
    Environmental Exposure
    Follow-Up Studies
    Humans
    Hypertension
    Incidence
    Lead
    Lead Poisoning
    Male
    Middle Aged
    Proportional Hazards Models
    Regression Analysis
    Risk Factors
    Severity of Illness Index
    Spectrometry, X-Ray Emission
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, Non-P.H.S.
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    11159162

    Citation

    Cheng, Y, et al. "Bone Lead and Blood Lead Levels in Relation to Baseline Blood Pressure and the Prospective Development of Hypertension: the Normative Aging Study." American Journal of Epidemiology, vol. 153, no. 2, 2001, pp. 164-71.
    Cheng Y, Schwartz J, Sparrow D, et al. Bone lead and blood lead levels in relation to baseline blood pressure and the prospective development of hypertension: the Normative Aging Study. Am J Epidemiol. 2001;153(2):164-71.
    Cheng, Y., Schwartz, J., Sparrow, D., Aro, A., Weiss, S. T., & Hu, H. (2001). Bone lead and blood lead levels in relation to baseline blood pressure and the prospective development of hypertension: the Normative Aging Study. American Journal of Epidemiology, 153(2), pp. 164-71.
    Cheng Y, et al. Bone Lead and Blood Lead Levels in Relation to Baseline Blood Pressure and the Prospective Development of Hypertension: the Normative Aging Study. Am J Epidemiol. 2001 Jan 15;153(2):164-71. PubMed PMID: 11159162.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Bone lead and blood lead levels in relation to baseline blood pressure and the prospective development of hypertension: the Normative Aging Study. AU - Cheng,Y, AU - Schwartz,J, AU - Sparrow,D, AU - Aro,A, AU - Weiss,S T, AU - Hu,H, PY - 2001/2/13/pubmed PY - 2001/3/3/medline PY - 2001/2/13/entrez SP - 164 EP - 71 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 153 IS - 2 N2 - Between 1991 and 1997, the authors studied 833 participants of the Normative Aging Study in a substudy of bone lead levels (measured by K-shell x-ray fluorescence), blood lead levels, and hypertension. Among these subjects, 337 were classified as normotensive, and 182 and 314 were classified as having borderline and definite hypertension, respectively, at baseline. These bone and blood lead levels were typical of those of community-exposed men. Among the 519 subjects with no history of definite hypertension at baseline, cross-sectional analyses revealed positive associations between systolic blood pressure and bone lead levels. Of the 474 subjects who were free from definite hypertension at baseline and had follow-up data, 74 new cases of definite hypertension were reported. Baseline bone lead levels were positively associated with incidence of hypertension. In proportional hazards models that controlled for age, age squared, body mass index, and family history of hypertension, an increase in patella (trabecular) lead from the midpoint of the lowest quintile to that of the highest quintile was associated with a rate ratio of definite hypertension of 1.71 (95% confidence interval: 1.08, 2.70). No association was found with blood lead level. These results support the hypothesis that cumulative exposure to lead, even at low levels sustained by the general population, may increase the risk of hypertension. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/11159162/Bone_lead_and_blood_lead_levels_in_relation_to_baseline_blood_pressure_and_the_prospective_development_of_hypertension:_the_Normative_Aging_Study_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/153.2.164 DB - PRIME DP - Unbound Medicine ER -