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Inverse association between intake of cereal fiber and risk of gastric cardia cancer.
Gastroenterology 2001; 120(2):387-91G

Abstract

BACKGROUND & AIMS

Recent data show that salivary nitrites form carcinogenic nitrosamines, especially at the gastric cardia. Wheat fiber has been shown to neutralize such mutagen formation. Our aim was to evaluate the association between dietary fiber and cancers of the esophageal and gastric cardia.

METHODS

We examined data from a large-scale population-based case-control study of risk factors for adenocarcinoma of the gastric cardia and esophagus and squamous cell carcinoma of the esophagus.

RESULTS

We found a strong dose-dependent inverse association between total dietary fiber intake and risk of gastric cardia adenocarcinoma, which was driven mainly by intake of cereal fiber. The odds ratio among individuals in the highest quartile of cereal fiber intake compared with the lowest was 0.3 (95% confidence interval, 0.2-0.5; P trend < 0.0001). High intake of cereal fiber was also associated with a moderately decreased risk of esophageal adenocarcinoma, but no linear dose-risk trend was observed. There was no association between dietary fiber and esophageal squamous cell carcinoma.

CONCLUSIONS

High intake of cereal fiber may significantly lower the risk of gastric cardia cancer.

Authors+Show Affiliations

Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11159879

Citation

Terry, P, et al. "Inverse Association Between Intake of Cereal Fiber and Risk of Gastric Cardia Cancer." Gastroenterology, vol. 120, no. 2, 2001, pp. 387-91.
Terry P, Lagergren J, Ye W, et al. Inverse association between intake of cereal fiber and risk of gastric cardia cancer. Gastroenterology. 2001;120(2):387-91.
Terry, P., Lagergren, J., Ye, W., Wolk, A., & Nyrén, O. (2001). Inverse association between intake of cereal fiber and risk of gastric cardia cancer. Gastroenterology, 120(2), pp. 387-91.
Terry P, et al. Inverse Association Between Intake of Cereal Fiber and Risk of Gastric Cardia Cancer. Gastroenterology. 2001;120(2):387-91. PubMed PMID: 11159879.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inverse association between intake of cereal fiber and risk of gastric cardia cancer. AU - Terry,P, AU - Lagergren,J, AU - Ye,W, AU - Wolk,A, AU - Nyrén,O, PY - 2001/2/13/pubmed PY - 2001/4/3/medline PY - 2001/2/13/entrez SP - 387 EP - 91 JF - Gastroenterology JO - Gastroenterology VL - 120 IS - 2 N2 - BACKGROUND & AIMS: Recent data show that salivary nitrites form carcinogenic nitrosamines, especially at the gastric cardia. Wheat fiber has been shown to neutralize such mutagen formation. Our aim was to evaluate the association between dietary fiber and cancers of the esophageal and gastric cardia. METHODS: We examined data from a large-scale population-based case-control study of risk factors for adenocarcinoma of the gastric cardia and esophagus and squamous cell carcinoma of the esophagus. RESULTS: We found a strong dose-dependent inverse association between total dietary fiber intake and risk of gastric cardia adenocarcinoma, which was driven mainly by intake of cereal fiber. The odds ratio among individuals in the highest quartile of cereal fiber intake compared with the lowest was 0.3 (95% confidence interval, 0.2-0.5; P trend < 0.0001). High intake of cereal fiber was also associated with a moderately decreased risk of esophageal adenocarcinoma, but no linear dose-risk trend was observed. There was no association between dietary fiber and esophageal squamous cell carcinoma. CONCLUSIONS: High intake of cereal fiber may significantly lower the risk of gastric cardia cancer. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/11159879/Inverse_association_between_intake_of_cereal_fiber_and_risk_of_gastric_cardia_cancer_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016508501641817 DB - PRIME DP - Unbound Medicine ER -