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Irritable bowel syndrome.

Abstract

The irritable bowel syndrome (IBS) is a functional gastrointestinal disorder whose hallmark is abdominal pain or discomfort associated with a change in the consistency or frequency of stools. In the western world, 8% to 23% of adults have IBS and its socioeconomic cost is substantial. Research-generated insights have led to the understanding of IBS as a disorder of brain-gut regulation. The experience of symptoms derives from dysregulation of the bidirectional communication system between the gastrointestinal tract and the brain, mediated by neuroendocrine and immunological factors and modulated by psychosocial factors. The biopsychosocial model integrates the various physical and psychosocial factors that contribute to the patient's illness. This model and the recently revised symptom-based criteria (i.e. the "Rome II criteria") form the basis for establishing a comprehensive and effective approach for the diagnosis and management of the disorder.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    UNC Center for Functional GI and Motility Disorders, Division of Digestive Diseases and Nutrition, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599-7080, USA. ringel@med.unc.edu

    ,

    Source

    Annual review of medicine 52: 2001 pg 319-38

    MeSH

    Colonic Diseases, Functional
    Dietary Fiber
    Gastrointestinal Motility
    Humans
    Life Style
    Parasympatholytics
    Psychotherapy
    Psychotropic Drugs

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    11160782

    Citation

    Ringel, Y, et al. "Irritable Bowel Syndrome." Annual Review of Medicine, vol. 52, 2001, pp. 319-38.
    Ringel Y, Sperber AD, Drossman DA. Irritable bowel syndrome. Annu Rev Med. 2001;52:319-38.
    Ringel, Y., Sperber, A. D., & Drossman, D. A. (2001). Irritable bowel syndrome. Annual Review of Medicine, 52, pp. 319-38.
    Ringel Y, Sperber AD, Drossman DA. Irritable Bowel Syndrome. Annu Rev Med. 2001;52:319-38. PubMed PMID: 11160782.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Irritable bowel syndrome. AU - Ringel,Y, AU - Sperber,A D, AU - Drossman,D A, PY - 2001/2/13/pubmed PY - 2001/5/1/medline PY - 2001/2/13/entrez SP - 319 EP - 38 JF - Annual review of medicine JO - Annu. Rev. Med. VL - 52 N2 - The irritable bowel syndrome (IBS) is a functional gastrointestinal disorder whose hallmark is abdominal pain or discomfort associated with a change in the consistency or frequency of stools. In the western world, 8% to 23% of adults have IBS and its socioeconomic cost is substantial. Research-generated insights have led to the understanding of IBS as a disorder of brain-gut regulation. The experience of symptoms derives from dysregulation of the bidirectional communication system between the gastrointestinal tract and the brain, mediated by neuroendocrine and immunological factors and modulated by psychosocial factors. The biopsychosocial model integrates the various physical and psychosocial factors that contribute to the patient's illness. This model and the recently revised symptom-based criteria (i.e. the "Rome II criteria") form the basis for establishing a comprehensive and effective approach for the diagnosis and management of the disorder. SN - 0066-4219 UR - https://www.unboundmedicine.com/medline/citation/11160782/full_citation L2 - http://arjournals.annualreviews.org/doi/full/10.1146/annurev.med.52.1.319?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -