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Atypical lobular hyperplasia or lobular carcinoma in situ at core-needle breast biopsy.
Radiology. 2001 Feb; 218(2):503-9.R

Abstract

PURPOSE

To review outcomes of lesions diagnosed at core-needle breast biopsy as atypical lobular hyperplasia (ALH) or lobular carcinoma in situ (LCIS).

MATERIALS AND METHODS

Results from 1,400 consecutive core-needle breast biopsies were reviewed. Twenty-five (1.8%) biopsy samples with the diagnosis of lobular neoplasia (15 with ALH and 10 with LCIS) adjacent to or in a targeted benign lesion were found. Lesions were excised (n = 15) or followed up (n = 10) at least 22 months.

RESULTS

Of the 15 lesions with ALH, 13 (87%) were adjacent to (n = 12) or associated with (n = 1) microcalcifications, and two (13%) were in masses. Six lesions with residual calcifications were excised. One lesion was diagnosed as ductal carcinoma in situ (DCIS), and five were benign (residual ALH was seen in four). One excised mass showed residual ALH. Six lesions were gone at follow-up, one cluster of microcalcifications was decreased in size, and one fibroadenoma with ALH was stable. Of the 10 lesions with LCIS, seven (70%) were adjacent to (n = 6) or associated with (n = 1) microcalcifications, and three (30%) were in or adjacent to masses. Five lesions with LCIS and residual microcalcifications were excised. Three yielded atypical ductal hyperplasia (ADH); one, residual LCIS; and one, ALH. Three masses with LCIS were excised. One showed residual LCIS; one, a papilloma with adjacent LCIS; and one, a fibroadenoma with LCIS in it. One cluster of microcalcifications was gone at follow-up, and one was stable.

CONCLUSION

After a diagnosis of lobular neoplasia at core biopsy, residual microcalcifications are viewed in the context of a patient at higher risk of cancer. Of 11 lesions with residual microcalcifications, three (27%) were ADH and one (9%) was DCIS.

Authors+Show Affiliations

Departments of Diagnostic Radiology, University of Maryland School of Medicine, Baltimore, USA. waberg@umaryland.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11161169

Citation

Berg, W A., et al. "Atypical Lobular Hyperplasia or Lobular Carcinoma in Situ at Core-needle Breast Biopsy." Radiology, vol. 218, no. 2, 2001, pp. 503-9.
Berg WA, Mrose HE, Ioffe OB. Atypical lobular hyperplasia or lobular carcinoma in situ at core-needle breast biopsy. Radiology. 2001;218(2):503-9.
Berg, W. A., Mrose, H. E., & Ioffe, O. B. (2001). Atypical lobular hyperplasia or lobular carcinoma in situ at core-needle breast biopsy. Radiology, 218(2), 503-9.
Berg WA, Mrose HE, Ioffe OB. Atypical Lobular Hyperplasia or Lobular Carcinoma in Situ at Core-needle Breast Biopsy. Radiology. 2001;218(2):503-9. PubMed PMID: 11161169.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Atypical lobular hyperplasia or lobular carcinoma in situ at core-needle breast biopsy. AU - Berg,W A, AU - Mrose,H E, AU - Ioffe,O B, PY - 2001/2/13/pubmed PY - 2001/5/18/medline PY - 2001/2/13/entrez SP - 503 EP - 9 JF - Radiology JO - Radiology VL - 218 IS - 2 N2 - PURPOSE: To review outcomes of lesions diagnosed at core-needle breast biopsy as atypical lobular hyperplasia (ALH) or lobular carcinoma in situ (LCIS). MATERIALS AND METHODS: Results from 1,400 consecutive core-needle breast biopsies were reviewed. Twenty-five (1.8%) biopsy samples with the diagnosis of lobular neoplasia (15 with ALH and 10 with LCIS) adjacent to or in a targeted benign lesion were found. Lesions were excised (n = 15) or followed up (n = 10) at least 22 months. RESULTS: Of the 15 lesions with ALH, 13 (87%) were adjacent to (n = 12) or associated with (n = 1) microcalcifications, and two (13%) were in masses. Six lesions with residual calcifications were excised. One lesion was diagnosed as ductal carcinoma in situ (DCIS), and five were benign (residual ALH was seen in four). One excised mass showed residual ALH. Six lesions were gone at follow-up, one cluster of microcalcifications was decreased in size, and one fibroadenoma with ALH was stable. Of the 10 lesions with LCIS, seven (70%) were adjacent to (n = 6) or associated with (n = 1) microcalcifications, and three (30%) were in or adjacent to masses. Five lesions with LCIS and residual microcalcifications were excised. Three yielded atypical ductal hyperplasia (ADH); one, residual LCIS; and one, ALH. Three masses with LCIS were excised. One showed residual LCIS; one, a papilloma with adjacent LCIS; and one, a fibroadenoma with LCIS in it. One cluster of microcalcifications was gone at follow-up, and one was stable. CONCLUSION: After a diagnosis of lobular neoplasia at core biopsy, residual microcalcifications are viewed in the context of a patient at higher risk of cancer. Of 11 lesions with residual microcalcifications, three (27%) were ADH and one (9%) was DCIS. SN - 0033-8419 UR - https://www.unboundmedicine.com/medline/citation/11161169/Atypical_lobular_hyperplasia_or_lobular_carcinoma_in_situ_at_core_needle_breast_biopsy_ L2 - https://pubs.rsna.org/doi/10.1148/radiology.218.2.r01fe32503?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -