Tags

Type your tag names separated by a space and hit enter

Pancreatic tumours: molecular pathways implicated in ductal cancer are involved in ampullary but not in exocrine nonductal or endocrine tumorigenesis.
Br J Cancer 2001; 84(2):253-62BJ

Abstract

Alterations of K- ras, p53, p16 and DPC4/Smad4 characterize pancreatic ductal cancer (PDC). Reports of inactivation of these latter two genes in pancreatic endocrine tumours (PET) suggest that common molecular pathways are involved in the tumorigenesis of pancreatic exocrine and endocrine epithelia. We characterized 112 primary pancreatic tumours for alterations in p16 and DPC4 and immunohistochemical expression of DPC4. The cases included 34 PDC, 10 intraductal papillary-mucinous tumours (IPMT), 6 acinar carcinomas (PAC), 5 solid-pseudopapillary tumours (SPT), 16 ampulla of Vater cancers (AVC) and 41 PET. All tumours were also presently or previously analysed for K- ras and p53 mutations and allelic loss at 9p, 17p and 18q. Alterations in K- ras, p53, p16 and DPC4 were found in 82%, 53%, 38% and 9% of PDC, respectively and in 47%, 60%, 25% and 6% of AVC. Alterations in these genes were virtually absent in PET, PAC or SPT, while in IPMT only K- ras mutations were present (30%). Positive immunostaining confirmed the absence of DPC4 alterations in all IPMT, SPT, PAC and PET, while 47% of PDC and 38% of AVC were immunonegative. These data suggest that pancreatic exocrine and endocrine tumourigenesis involves different genetic targets and that among exocrine pancreatic neoplasms, only ductal and ampullary cancers share common molecular events.

Authors+Show Affiliations

Department of Pathology, Università di Verona, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11161385

Citation

Moore, P S., et al. "Pancreatic Tumours: Molecular Pathways Implicated in Ductal Cancer Are Involved in Ampullary but Not in Exocrine Nonductal or Endocrine Tumorigenesis." British Journal of Cancer, vol. 84, no. 2, 2001, pp. 253-62.
Moore PS, Orlandini S, Zamboni G, et al. Pancreatic tumours: molecular pathways implicated in ductal cancer are involved in ampullary but not in exocrine nonductal or endocrine tumorigenesis. Br J Cancer. 2001;84(2):253-62.
Moore, P. S., Orlandini, S., Zamboni, G., Capelli, P., Rigaud, G., Falconi, M., ... Scarpa, A. (2001). Pancreatic tumours: molecular pathways implicated in ductal cancer are involved in ampullary but not in exocrine nonductal or endocrine tumorigenesis. British Journal of Cancer, 84(2), pp. 253-62.
Moore PS, et al. Pancreatic Tumours: Molecular Pathways Implicated in Ductal Cancer Are Involved in Ampullary but Not in Exocrine Nonductal or Endocrine Tumorigenesis. Br J Cancer. 2001;84(2):253-62. PubMed PMID: 11161385.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pancreatic tumours: molecular pathways implicated in ductal cancer are involved in ampullary but not in exocrine nonductal or endocrine tumorigenesis. AU - Moore,P S, AU - Orlandini,S, AU - Zamboni,G, AU - Capelli,P, AU - Rigaud,G, AU - Falconi,M, AU - Bassi,C, AU - Lemoine,N R, AU - Scarpa,A, PY - 2001/2/13/pubmed PY - 2001/3/10/medline PY - 2001/2/13/entrez SP - 253 EP - 62 JF - British journal of cancer JO - Br. J. Cancer VL - 84 IS - 2 N2 - Alterations of K- ras, p53, p16 and DPC4/Smad4 characterize pancreatic ductal cancer (PDC). Reports of inactivation of these latter two genes in pancreatic endocrine tumours (PET) suggest that common molecular pathways are involved in the tumorigenesis of pancreatic exocrine and endocrine epithelia. We characterized 112 primary pancreatic tumours for alterations in p16 and DPC4 and immunohistochemical expression of DPC4. The cases included 34 PDC, 10 intraductal papillary-mucinous tumours (IPMT), 6 acinar carcinomas (PAC), 5 solid-pseudopapillary tumours (SPT), 16 ampulla of Vater cancers (AVC) and 41 PET. All tumours were also presently or previously analysed for K- ras and p53 mutations and allelic loss at 9p, 17p and 18q. Alterations in K- ras, p53, p16 and DPC4 were found in 82%, 53%, 38% and 9% of PDC, respectively and in 47%, 60%, 25% and 6% of AVC. Alterations in these genes were virtually absent in PET, PAC or SPT, while in IPMT only K- ras mutations were present (30%). Positive immunostaining confirmed the absence of DPC4 alterations in all IPMT, SPT, PAC and PET, while 47% of PDC and 38% of AVC were immunonegative. These data suggest that pancreatic exocrine and endocrine tumourigenesis involves different genetic targets and that among exocrine pancreatic neoplasms, only ductal and ampullary cancers share common molecular events. SN - 0007-0920 UR - https://www.unboundmedicine.com/medline/citation/11161385/Pancreatic_tumours:_molecular_pathways_implicated_in_ductal_cancer_are_involved_in_ampullary_but_not_in_exocrine_nonductal_or_endocrine_tumorigenesis_ L2 - http://dx.doi.org/10.1054/bjoc.2000.1567 DB - PRIME DP - Unbound Medicine ER -