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Exposure to manganese: health effects on the general population, a pilot study in central Mexico.
Environ Res. 2001 Feb; 85(2):90-104.ER

Abstract

To support a risk assessment of manganese exposure in two communities living within a manganese mining district a cross-sectional study was performed on a sample of the adult population of long-term residents. One community was exposed to a point source from an ore primary refining plant. Manganese is an essential mineral for human life. It is also the fourth in importance for industrial metal making. Data were collected on socioeconomic living conditions, emission sources, environmental media concentrations (air, water, soil, dust, food), respiratory symptomatology, and a neuropsychological examination (Mini-Mental Screening test, the Hooper Visual Organization test, the Ardila-Ostroski, and others). We examined 73 subjects (52 women), most of low socioeconomic status. Environmental air concentrations were 2 to 3 times higher than those in other urban concentrations. Manganese blood concentrations ranged from 7.5 to 88 microg/L, with a median concentration of 15, the upper quartile starting at 20 microg/L; the upper 10% was above 25 microg/L. Lead and manganese were highly correlated; there was an inverse relation to hemoglobin. Reduced levels of plasma lipid peroxidation were associated with blood manganese. Using multivariate logistic regression, we identified B-Mn as increasing the risk of deficient cognitive performance 12 times (Mini-Mental score of less than 17).

Authors+Show Affiliations

Instituto de Salud Ambiente y Trabajo, Cerrada del Convento 48-A, Colonia Santa Ursula Xitla, Tlalpan, D.F. c.p. 14420, Mexico. carlos.santos-burgoa@isat.org.mxNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11161659

Citation

Santos-Burgoa, C, et al. "Exposure to Manganese: Health Effects On the General Population, a Pilot Study in Central Mexico." Environmental Research, vol. 85, no. 2, 2001, pp. 90-104.
Santos-Burgoa C, Rios C, Mercado LA, et al. Exposure to manganese: health effects on the general population, a pilot study in central Mexico. Environ Res. 2001;85(2):90-104.
Santos-Burgoa, C., Rios, C., Mercado, L. A., Arechiga-Serrano, R., Cano-Valle, F., Eden-Wynter, R. A., Texcalac-Sangrador, J. L., Villa-Barragan, J. P., Rodriguez-Agudelo, Y., & Montes, S. (2001). Exposure to manganese: health effects on the general population, a pilot study in central Mexico. Environmental Research, 85(2), 90-104.
Santos-Burgoa C, et al. Exposure to Manganese: Health Effects On the General Population, a Pilot Study in Central Mexico. Environ Res. 2001;85(2):90-104. PubMed PMID: 11161659.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exposure to manganese: health effects on the general population, a pilot study in central Mexico. AU - Santos-Burgoa,C, AU - Rios,C, AU - Mercado,L A, AU - Arechiga-Serrano,R, AU - Cano-Valle,F, AU - Eden-Wynter,R A, AU - Texcalac-Sangrador,J L, AU - Villa-Barragan,J P, AU - Rodriguez-Agudelo,Y, AU - Montes,S, PY - 2001/2/13/pubmed PY - 2001/4/3/medline PY - 2001/2/13/entrez SP - 90 EP - 104 JF - Environmental research JO - Environ Res VL - 85 IS - 2 N2 - To support a risk assessment of manganese exposure in two communities living within a manganese mining district a cross-sectional study was performed on a sample of the adult population of long-term residents. One community was exposed to a point source from an ore primary refining plant. Manganese is an essential mineral for human life. It is also the fourth in importance for industrial metal making. Data were collected on socioeconomic living conditions, emission sources, environmental media concentrations (air, water, soil, dust, food), respiratory symptomatology, and a neuropsychological examination (Mini-Mental Screening test, the Hooper Visual Organization test, the Ardila-Ostroski, and others). We examined 73 subjects (52 women), most of low socioeconomic status. Environmental air concentrations were 2 to 3 times higher than those in other urban concentrations. Manganese blood concentrations ranged from 7.5 to 88 microg/L, with a median concentration of 15, the upper quartile starting at 20 microg/L; the upper 10% was above 25 microg/L. Lead and manganese were highly correlated; there was an inverse relation to hemoglobin. Reduced levels of plasma lipid peroxidation were associated with blood manganese. Using multivariate logistic regression, we identified B-Mn as increasing the risk of deficient cognitive performance 12 times (Mini-Mental score of less than 17). SN - 0013-9351 UR - https://www.unboundmedicine.com/medline/citation/11161659/Exposure_to_manganese:_health_effects_on_the_general_population_a_pilot_study_in_central_Mexico_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0013-9351(00)94108-2 DB - PRIME DP - Unbound Medicine ER -