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The role of respiratory viruses in otitis media.
Vaccine. 2000 Dec 08; 19 Suppl 1:S51-5.V

Abstract

Evidence derived from numerous studies ranging from animal experiments to extensive clinical trials supports a crucial role for respiratory viruses in acute otitis media. Viral infection of the upper respiratory tract initiates the whole cascade of events that ultimately leads to development of acute otitis media, and viruses contribute to the pathogenesis of this disease by several mechanisms. Recent data indicate that at least some types of viruses actively invade the middle ear and may also interfere with the outcome of otitis media. The availability of effective vaccines against the principal viruses predisposing to acute otitis media could be expected to result in a substantial reduction in the incidence of this disease.

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Publisher Full Text

Authors+Show Affiliations

Heikkinen T
Department of Pediatrics, Turku University Hospital, FIN-20520 Turku, Finland. terho.heikkinen@utu.fi

MeSH

Adenoviridae InfectionsChild, PreschoolDisease SusceptibilityEar, MiddleEustachian TubeHumansInfantInfluenza A virusInfluenza, HumanNasopharynxOtitis MediaParamyxoviridae InfectionsPneumococcal InfectionsRespiratory Syncytial Virus InfectionsRespiratory Tract InfectionsStreptococcus pneumoniaeSuperinfectionTreatment OutcomeVaccinationViral Vaccines

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

11163463

Citation

Heikkinen, T. "The Role of Respiratory Viruses in Otitis Media." Vaccine, vol. 19 Suppl 1, 2000, pp. S51-5.
Heikkinen T. The role of respiratory viruses in otitis media. Vaccine. 2000;19 Suppl 1:S51-5.
Heikkinen, T. (2000). The role of respiratory viruses in otitis media. Vaccine, 19 Suppl 1, S51-5.
Heikkinen T. The Role of Respiratory Viruses in Otitis Media. Vaccine. 2000 Dec 8;19 Suppl 1:S51-5. PubMed PMID: 11163463.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of respiratory viruses in otitis media. A1 - Heikkinen,T, PY - 2001/2/13/pubmed PY - 2001/7/6/medline PY - 2001/2/13/entrez SP - S51 EP - 5 JF - Vaccine JO - Vaccine VL - 19 Suppl 1 N2 - Evidence derived from numerous studies ranging from animal experiments to extensive clinical trials supports a crucial role for respiratory viruses in acute otitis media. Viral infection of the upper respiratory tract initiates the whole cascade of events that ultimately leads to development of acute otitis media, and viruses contribute to the pathogenesis of this disease by several mechanisms. Recent data indicate that at least some types of viruses actively invade the middle ear and may also interfere with the outcome of otitis media. The availability of effective vaccines against the principal viruses predisposing to acute otitis media could be expected to result in a substantial reduction in the incidence of this disease. SN - 0264-410X UR - https://www.unboundmedicine.com/medline/citation/11163463/The_role_of_respiratory_viruses_in_otitis_media_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264410X00002784 DB - PRIME DP - Unbound Medicine ER -