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Nutritional status of folate and colon cancer risk: evidence from NHANES I epidemiologic follow-up study.
Ann Epidemiol 2001; 11(1):65-72AE

Abstract

PURPOSE

This manuscript utilized the NHANES I Epidemiologic Follow-up Study (NHEFS), a national probability sample of the U.S. non-institutionalized population, to examine whether the intake of folate at baseline is associated with colon cancer risk.

METHODS

The NHEFS consists of 14,407 subjects with 20 years of follow-up. Sociodemographic status, dietary information, family history of colon cancer, alcohol and aspirin use, smoking status, and body mass index (BMI) are included in the Cox proportional hazard model to examine confounding effects.

RESULTS

After adjusting for confounders, a marginally significant association was observed between folate intake and reduced colon cancer risk. Gender and alcohol consumption appears to have an interactive effect with this association. The stratified results suggest that dietary folate is significantly inversely associated with colon cancer in men (relative risk (RR) = 0.40, 95% confidence interval (CI) = 0.18, 0.88) who consumed more than 249 microg/day of folate and that there is a significant dose-response relationship (p = 0.03). The association did not reach statistical significance in women. Using a composite dietary profile, we found that there is a significantly increased risk for men who consumed low-folate, low-methionine, and high alcohol diets when compared to male non-drinkers who consumed high-folate and high methionine diets (RR = 2.67, 95% CI = 1.16, 6.16).

CONCLUSIONS

This study found significant association between folate intake and reduced colon cancer risk among men and non-drinkers, but not women or drinkers. The study supports a synergistic interaction between intakes of folate, methionine and alcohol and colon cancer risk.

Authors+Show Affiliations

Department of Public Health and Preventive Medicine and Stanley S. Scott Cancer Center, Louisiana State University Medical Center, New Orleans, USA.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11164122

Citation

Su, L J., and L Arab. "Nutritional Status of Folate and Colon Cancer Risk: Evidence From NHANES I Epidemiologic Follow-up Study." Annals of Epidemiology, vol. 11, no. 1, 2001, pp. 65-72.
Su LJ, Arab L. Nutritional status of folate and colon cancer risk: evidence from NHANES I epidemiologic follow-up study. Ann Epidemiol. 2001;11(1):65-72.
Su, L. J., & Arab, L. (2001). Nutritional status of folate and colon cancer risk: evidence from NHANES I epidemiologic follow-up study. Annals of Epidemiology, 11(1), pp. 65-72.
Su LJ, Arab L. Nutritional Status of Folate and Colon Cancer Risk: Evidence From NHANES I Epidemiologic Follow-up Study. Ann Epidemiol. 2001;11(1):65-72. PubMed PMID: 11164122.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nutritional status of folate and colon cancer risk: evidence from NHANES I epidemiologic follow-up study. AU - Su,L J, AU - Arab,L, PY - 2001/2/13/pubmed PY - 2001/3/17/medline PY - 2001/2/13/entrez SP - 65 EP - 72 JF - Annals of epidemiology JO - Ann Epidemiol VL - 11 IS - 1 N2 - PURPOSE: This manuscript utilized the NHANES I Epidemiologic Follow-up Study (NHEFS), a national probability sample of the U.S. non-institutionalized population, to examine whether the intake of folate at baseline is associated with colon cancer risk. METHODS: The NHEFS consists of 14,407 subjects with 20 years of follow-up. Sociodemographic status, dietary information, family history of colon cancer, alcohol and aspirin use, smoking status, and body mass index (BMI) are included in the Cox proportional hazard model to examine confounding effects. RESULTS: After adjusting for confounders, a marginally significant association was observed between folate intake and reduced colon cancer risk. Gender and alcohol consumption appears to have an interactive effect with this association. The stratified results suggest that dietary folate is significantly inversely associated with colon cancer in men (relative risk (RR) = 0.40, 95% confidence interval (CI) = 0.18, 0.88) who consumed more than 249 microg/day of folate and that there is a significant dose-response relationship (p = 0.03). The association did not reach statistical significance in women. Using a composite dietary profile, we found that there is a significantly increased risk for men who consumed low-folate, low-methionine, and high alcohol diets when compared to male non-drinkers who consumed high-folate and high methionine diets (RR = 2.67, 95% CI = 1.16, 6.16). CONCLUSIONS: This study found significant association between folate intake and reduced colon cancer risk among men and non-drinkers, but not women or drinkers. The study supports a synergistic interaction between intakes of folate, methionine and alcohol and colon cancer risk. SN - 1047-2797 UR - https://www.unboundmedicine.com/medline/citation/11164122/Nutritional_status_of_folate_and_colon_cancer_risk:_evidence_from_NHANES_I_epidemiologic_follow_up_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1047-2797(00)00188-5 DB - PRIME DP - Unbound Medicine ER -