Tags

Type your tag names separated by a space and hit enter

Elevated plasma homocysteine levels in centenarians are not associated with cognitive impairment.
Mech Ageing Dev 2000; 121(1-3):251-61MA

Abstract

BACKGROUND

Previous reports have shown elevated plasma total homocysteine (tHcy) levels in elderly person with impaired cognition.

OBJECTIVE

To study the association between cognitive status and plasma tHcy levels in centenarians.

DESIGN

Cross-sectional survey.

SETTING

Centenarians living in two northern Italian provinces.

PARTICIPANTS

Thirteen cognitively normal centenarians, ten cognitively impaired not-demented centenarians, and 34 demented centenarians with a clinical diagnosis of Alzheimer's disease (AD).

MEASUREMENTS

Blood levels of homocysteine's biological determinants vitamin B12, folate, and vitamin B6.

RESULTS

Elevated plasma tHcy levels (>17 micromol/l) were common in the general population (77% of normal centenarians, 100% of cognitively impaired not-demented centenarians, 82% of AD centenarians). Demented centenarians had the lowest folate serum levels. Low or borderline vitamin B12 serum levels (<221 pmol/l) and low vitamin B6 plasma levels (<11.7 nmol/l) were found in 33 and 66% of all centenarians independently of cognitive status. Among demented centenarians only plasma tHcy correlated inversely with both serum vitamin B12 and folate. No significant difference was found for plasma tHcy levels among the three diagnostic groups, even after adjusting for B vitamin levels.

CONCLUSIONS

Hyperhomocysteinemia is very common among centenarians, probably due to vitamin deficiencies, but does not seem to be associated with cognitive impairment.

Authors+Show Affiliations

Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital S. Orsola-Malpighi, Via Massarenti 9, 40138 Bologna, Italy. ravaglia@almadns.unibo.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11164478

Citation

Ravaglia, G, et al. "Elevated Plasma Homocysteine Levels in Centenarians Are Not Associated With Cognitive Impairment." Mechanisms of Ageing and Development, vol. 121, no. 1-3, 2000, pp. 251-61.
Ravaglia G, Forti P, Maioli F, et al. Elevated plasma homocysteine levels in centenarians are not associated with cognitive impairment. Mech Ageing Dev. 2000;121(1-3):251-61.
Ravaglia, G., Forti, P., Maioli, F., Vettori, C., Grossi, G., Bargossi, A. M., ... Cavalli, G. (2000). Elevated plasma homocysteine levels in centenarians are not associated with cognitive impairment. Mechanisms of Ageing and Development, 121(1-3), pp. 251-61.
Ravaglia G, et al. Elevated Plasma Homocysteine Levels in Centenarians Are Not Associated With Cognitive Impairment. Mech Ageing Dev. 2000 Dec 20;121(1-3):251-61. PubMed PMID: 11164478.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elevated plasma homocysteine levels in centenarians are not associated with cognitive impairment. AU - Ravaglia,G, AU - Forti,P, AU - Maioli,F, AU - Vettori,C, AU - Grossi,G, AU - Bargossi,A M, AU - Caldarera,M, AU - Franceschi,C, AU - Facchini,A, AU - Mariani,E, AU - Cavalli,G, PY - 2001/2/13/pubmed PY - 2001/5/22/medline PY - 2001/2/13/entrez SP - 251 EP - 61 JF - Mechanisms of ageing and development JO - Mech. Ageing Dev. VL - 121 IS - 1-3 N2 - BACKGROUND: Previous reports have shown elevated plasma total homocysteine (tHcy) levels in elderly person with impaired cognition. OBJECTIVE: To study the association between cognitive status and plasma tHcy levels in centenarians. DESIGN: Cross-sectional survey. SETTING: Centenarians living in two northern Italian provinces. PARTICIPANTS: Thirteen cognitively normal centenarians, ten cognitively impaired not-demented centenarians, and 34 demented centenarians with a clinical diagnosis of Alzheimer's disease (AD). MEASUREMENTS: Blood levels of homocysteine's biological determinants vitamin B12, folate, and vitamin B6. RESULTS: Elevated plasma tHcy levels (>17 micromol/l) were common in the general population (77% of normal centenarians, 100% of cognitively impaired not-demented centenarians, 82% of AD centenarians). Demented centenarians had the lowest folate serum levels. Low or borderline vitamin B12 serum levels (<221 pmol/l) and low vitamin B6 plasma levels (<11.7 nmol/l) were found in 33 and 66% of all centenarians independently of cognitive status. Among demented centenarians only plasma tHcy correlated inversely with both serum vitamin B12 and folate. No significant difference was found for plasma tHcy levels among the three diagnostic groups, even after adjusting for B vitamin levels. CONCLUSIONS: Hyperhomocysteinemia is very common among centenarians, probably due to vitamin deficiencies, but does not seem to be associated with cognitive impairment. SN - 0047-6374 UR - https://www.unboundmedicine.com/medline/citation/11164478/Elevated_plasma_homocysteine_levels_in_centenarians_are_not_associated_with_cognitive_impairment_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0047637400002219 DB - PRIME DP - Unbound Medicine ER -